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Published in: Pediatric Nephrology 8/2012

01-08-2012 | Original Article

Ambulatory blood pressure in prehypertensive children and adolescents

Authors: Hisayo Fujita, Seiji Matsuoka, Midori Awazu

Published in: Pediatric Nephrology | Issue 8/2012

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Abstract

Background

Prehypertension is defined as blood pressure (BP) ≥90th percentile, or ≥120/80 mmHg, but <95th percentile for age, sex, and height. Since the definition is made by conventional BP measurements and office BP can be quite variable, we studied whether prehypertension could be differentiated by ambulatory BP monitoring from normotension or hypertension (HTN) in children and adolescents.

Methods

One hundred and fifty-eight children (84 boys and 74 girls, aged 6–17 years, median 12) were studied. According to the office BP values, they were divided into normotension (80), prehypertension (20), and HTN (58).

Results

Systolic BP index and systolic daytime ambulatory BP (ABP) were significantly higher in prehypertensive patients than in normotensives and lower than hypertensives. When daytime ABP was used to diagnose HTN, four normotensive (5.0%), four prehypertensive (20.0%), and 27 hypertensive (46.6%) patients had HTN. Thus, in patients with prehypertension, the prevalence of masked HTN is significantly higher than in those with normotension. On the other hand, the prevalence of daytime ambulatory HTN is significantly lower, i.e., white-coat effect is more frequent, compared with hypertensive patients.

Conclusion

Prehypertension lies between normotension and HTN in ABP values as well and is a good candidate for identifying masked HTN. Our data emphasize the importance of identifying prehypertension in children and adolescents.
Literature
1.
go back to reference Lubrano R, Travasso E, Raggi C, Guido G, Masciangelo R, Elli M (2009) Blood pressure load, proteinuria and renal function in pre-hypertensive children. Pediatr Nephrol 24:823–831PubMedCrossRef Lubrano R, Travasso E, Raggi C, Guido G, Masciangelo R, Elli M (2009) Blood pressure load, proteinuria and renal function in pre-hypertensive children. Pediatr Nephrol 24:823–831PubMedCrossRef
2.
go back to reference Stabouli S, Kotsis V, Rizos Z, Toumanidis S, Karagianni C, Constantopoulos A, Zakopoulos N (2009) Left ventricular mass in normotensive, prehypertensive and hypertensive children and adolescents. Pediatr Nephrol 24:1545–1551PubMedCrossRef Stabouli S, Kotsis V, Rizos Z, Toumanidis S, Karagianni C, Constantopoulos A, Zakopoulos N (2009) Left ventricular mass in normotensive, prehypertensive and hypertensive children and adolescents. Pediatr Nephrol 24:1545–1551PubMedCrossRef
3.
go back to reference Drukteinis JS, Roman MJ, Fabsitz RR, Lee ET, Best LG, Russell M, Devereux RB (2007) Cardiac and systemic hemodynamic characteristics of hypertension and prehypertension in adolescents and young adults: the Strong Heart Study. Circulation 115:221–227PubMedCrossRef Drukteinis JS, Roman MJ, Fabsitz RR, Lee ET, Best LG, Russell M, Devereux RB (2007) Cardiac and systemic hemodynamic characteristics of hypertension and prehypertension in adolescents and young adults: the Strong Heart Study. Circulation 115:221–227PubMedCrossRef
4.
go back to reference Matsuoka S, Kawamura K, Honda M, Awazu M (2002) White coat effect and white coat hypertension in pediatric patients. Pediatr Nephrol 17:950–953PubMedCrossRef Matsuoka S, Kawamura K, Honda M, Awazu M (2002) White coat effect and white coat hypertension in pediatric patients. Pediatr Nephrol 17:950–953PubMedCrossRef
5.
go back to reference National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114:555–576CrossRef National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114:555–576CrossRef
6.
go back to reference Sorof JM, Poffenbarger T, Franco K, Portman R (2001) Evaluation of white coat hypertension in children: importance of the definitions of normal ambulatory blood pressure and the severity of casual hypertension. Am J Hypertens 14:855–860PubMedCrossRef Sorof JM, Poffenbarger T, Franco K, Portman R (2001) Evaluation of white coat hypertension in children: importance of the definitions of normal ambulatory blood pressure and the severity of casual hypertension. Am J Hypertens 14:855–860PubMedCrossRef
7.
go back to reference Awazu M, Matsuoka S, Kamimaki T, Watanabe H, Matsuo N (2000) Absent circadian variation of blood pressure in patients with anorexia nervosa. J Pediatr 136:524–527PubMedCrossRef Awazu M, Matsuoka S, Kamimaki T, Watanabe H, Matsuo N (2000) Absent circadian variation of blood pressure in patients with anorexia nervosa. J Pediatr 136:524–527PubMedCrossRef
8.
go back to reference Soergel M, Kirschstein M, Busch C, Danne T, Gellermann J, Holl R, Krull F, Reichert H, Reusz GS, Rascher W (1997) Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 patients. J Pediatr 130:178–184PubMedCrossRef Soergel M, Kirschstein M, Busch C, Danne T, Gellermann J, Holl R, Krull F, Reichert H, Reusz GS, Rascher W (1997) Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 patients. J Pediatr 130:178–184PubMedCrossRef
9.
go back to reference Hansen ML, Gunn PW, Kaelber DC (2007) Underdiagnosis of hypertension in children and adolescents. JAMA 298:874–879PubMedCrossRef Hansen ML, Gunn PW, Kaelber DC (2007) Underdiagnosis of hypertension in children and adolescents. JAMA 298:874–879PubMedCrossRef
10.
go back to reference McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ (2007) Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr 150:640–644PubMedCrossRef McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ (2007) Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr 150:640–644PubMedCrossRef
11.
go back to reference Srinivasan SR, Myers L, Berenson GS (2006) Changes in metabolic syndrome variables since childhood in prehypertensive and hypertensive patients: the Bogalusa Heart Study. Hypertension 48:33–39PubMedCrossRef Srinivasan SR, Myers L, Berenson GS (2006) Changes in metabolic syndrome variables since childhood in prehypertensive and hypertensive patients: the Bogalusa Heart Study. Hypertension 48:33–39PubMedCrossRef
12.
go back to reference Falkner B, Gidding SS, Portman R, Rosner B (2008) Blood pressure variability and classification of prehypertension and hypertension in adolescence. Pediatrics 122:238–242PubMedCrossRef Falkner B, Gidding SS, Portman R, Rosner B (2008) Blood pressure variability and classification of prehypertension and hypertension in adolescence. Pediatrics 122:238–242PubMedCrossRef
13.
go back to reference Genovesi S, Antolini L, Giussani M, Brambilla P, Barbieri V, Galbiati S, Mastriani S, Sala V, Valsecchi MG, Stella A (2010) Hypertension, prehypertension, and transient elevated blood pressure in children: association with weight excess and waist circumference. Am J Hypertens 23:756–761PubMedCrossRef Genovesi S, Antolini L, Giussani M, Brambilla P, Barbieri V, Galbiati S, Mastriani S, Sala V, Valsecchi MG, Stella A (2010) Hypertension, prehypertension, and transient elevated blood pressure in children: association with weight excess and waist circumference. Am J Hypertens 23:756–761PubMedCrossRef
14.
go back to reference Matsuoka S, Awazu M (2004) Masked hypertension in children and young adults. Pediatr Nephrol 19:651–654PubMedCrossRef Matsuoka S, Awazu M (2004) Masked hypertension in children and young adults. Pediatr Nephrol 19:651–654PubMedCrossRef
15.
go back to reference Sega R, Trocino G, Lanzarotti A, Carugo S, Cesana G, Schiavina R, Valagussa F, Bombelli M, Giannattasio C, Zanchetti A, Mancia G (2001) Alterations of cardiac structure in patients with isolated office, ambulatory, or home hypertension: Data from the general population (Pressione Arteriose Monitorate E Loro Associazioni [PAMELA] Study). Circulation 104:1385–1392PubMedCrossRef Sega R, Trocino G, Lanzarotti A, Carugo S, Cesana G, Schiavina R, Valagussa F, Bombelli M, Giannattasio C, Zanchetti A, Mancia G (2001) Alterations of cardiac structure in patients with isolated office, ambulatory, or home hypertension: Data from the general population (Pressione Arteriose Monitorate E Loro Associazioni [PAMELA] Study). Circulation 104:1385–1392PubMedCrossRef
16.
go back to reference Liu JE, Roman MJ, Pini R, Schwartz JE, Pickering TG, Devereux RB (1999) Cardiac and arterial target organ damage in adults with elevated ambulatory and normal office blood pressure. Ann Intern Med 131:564–572PubMed Liu JE, Roman MJ, Pini R, Schwartz JE, Pickering TG, Devereux RB (1999) Cardiac and arterial target organ damage in adults with elevated ambulatory and normal office blood pressure. Ann Intern Med 131:564–572PubMed
17.
go back to reference Stergiou GS, Rarra VC, Yiannes NG (2009) Prevalence and predictors of masked hypertension detected by home blood pressure monitoring in children and adolescents: the Arsakeion School study. Am J Hypertens 22:520–524PubMedCrossRef Stergiou GS, Rarra VC, Yiannes NG (2009) Prevalence and predictors of masked hypertension detected by home blood pressure monitoring in children and adolescents: the Arsakeion School study. Am J Hypertens 22:520–524PubMedCrossRef
18.
go back to reference Stabouli S, Kotsis V, Toumanidis S, Papamichael C, Constantopoulos A, Zakopoulos N (2005) White-coat and masked hypertension in children: association with target-organ damage. Pediatr Nephrol 20:1151–1155PubMedCrossRef Stabouli S, Kotsis V, Toumanidis S, Papamichael C, Constantopoulos A, Zakopoulos N (2005) White-coat and masked hypertension in children: association with target-organ damage. Pediatr Nephrol 20:1151–1155PubMedCrossRef
19.
go back to reference Lurbe E, Torro I, Alvarez V, Nawrot T, Paya R, Redon J, Staessen JA (2005) Prevalence, persistence, and clinical significance of masked hypertension in youth. Hypertension 45:493–498PubMedCrossRef Lurbe E, Torro I, Alvarez V, Nawrot T, Paya R, Redon J, Staessen JA (2005) Prevalence, persistence, and clinical significance of masked hypertension in youth. Hypertension 45:493–498PubMedCrossRef
20.
go back to reference McNiece KL, Gupta-Malhotra M, Samuels J, Bell C, Garcia K, Poffenbarger T, Sorof JM, Portman RJ (2007) Left ventricular hypertrophy in hypertensive adolescents: analysis of risk by 2004 National High Blood Pressure Education Program Working Group staging criteria. Hypertension 50:392–395PubMedCrossRef McNiece KL, Gupta-Malhotra M, Samuels J, Bell C, Garcia K, Poffenbarger T, Sorof JM, Portman RJ (2007) Left ventricular hypertrophy in hypertensive adolescents: analysis of risk by 2004 National High Blood Pressure Education Program Working Group staging criteria. Hypertension 50:392–395PubMedCrossRef
21.
go back to reference Pickering TG (2007) The natural history of hypertension: prehypertension or masked hypertension? J Clin Hypertens (Greenwich) 9:807–810CrossRef Pickering TG (2007) The natural history of hypertension: prehypertension or masked hypertension? J Clin Hypertens (Greenwich) 9:807–810CrossRef
22.
go back to reference Pierdomenico SD, Pannarale G, Rabbia F, Lapenna D, Licitra R, Zito M, Campanella M, Gaudio C, Veglio F, Cuccurullo F (2008) Prognostic relevance of masked hypertension in patients with prehypertension. Am J Hypertens 21:879–883PubMedCrossRef Pierdomenico SD, Pannarale G, Rabbia F, Lapenna D, Licitra R, Zito M, Campanella M, Gaudio C, Veglio F, Cuccurullo F (2008) Prognostic relevance of masked hypertension in patients with prehypertension. Am J Hypertens 21:879–883PubMedCrossRef
23.
go back to reference Wühl E, Witte K, Soergel M, Mehls O, Schaefer F (2002) Distribution of 24-h ambulatory blood pressure in children: normalized reference values and role of body dimensions. J Hypertens 20:1995–2007PubMedCrossRef Wühl E, Witte K, Soergel M, Mehls O, Schaefer F (2002) Distribution of 24-h ambulatory blood pressure in children: normalized reference values and role of body dimensions. J Hypertens 20:1995–2007PubMedCrossRef
24.
go back to reference Bell CS, Poffenbarger TS, Samuels JA (2011) Ambulatory blood pressure status in children: comparing alternate limit sources. Pediatr Nephrol 26:2211–2217PubMedCrossRef Bell CS, Poffenbarger TS, Samuels JA (2011) Ambulatory blood pressure status in children: comparing alternate limit sources. Pediatr Nephrol 26:2211–2217PubMedCrossRef
25.
go back to reference Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M, Mahoney L, McCrindle B, Mietus-Snyder M, Steinberger J, Daniels S (2008) Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the council on cardiovascular disease in the young and the council for high blood pressure research. Hypertension 52:433–451PubMedCrossRef Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M, Mahoney L, McCrindle B, Mietus-Snyder M, Steinberger J, Daniels S (2008) Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the council on cardiovascular disease in the young and the council for high blood pressure research. Hypertension 52:433–451PubMedCrossRef
26.
go back to reference Flynn JT (2011) Ambulatory blood pressure monitoring in children: imperfect yet essential. Pediatr Nephrol 26:2089–2094PubMedCrossRef Flynn JT (2011) Ambulatory blood pressure monitoring in children: imperfect yet essential. Pediatr Nephrol 26:2089–2094PubMedCrossRef
27.
go back to reference Zhuo S, Wen W, Li-Yuan M, Shu-Yu W, Yi-Xin W (2009) Home blood pressure measurement in prehypertension and untreated hypertension: comparison with ambulatory blood pressure monitoring and office blood pressure. Blood Press Monit 14:245–250PubMedCrossRef Zhuo S, Wen W, Li-Yuan M, Shu-Yu W, Yi-Xin W (2009) Home blood pressure measurement in prehypertension and untreated hypertension: comparison with ambulatory blood pressure monitoring and office blood pressure. Blood Press Monit 14:245–250PubMedCrossRef
Metadata
Title
Ambulatory blood pressure in prehypertensive children and adolescents
Authors
Hisayo Fujita
Seiji Matsuoka
Midori Awazu
Publication date
01-08-2012
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 8/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-012-2148-2

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