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Pediatric Nephrology

Published in:

01-05-2012 | Brief Report

Linear nevus sebaceous syndrome with hypophosphatemic rickets with elevated FGF-23

Authors: Ryo Narazaki, Kenji Ihara, Noriyuki Namba, Hiroshi Matsuzaki, Keiichi Ozono, Toshiro Hara

Published in: Pediatric Nephrology | Issue 5/2012

Abstract

Background

Linear nevus sebaceous syndrome (LNSS) is a rare congenital neuroectodermal disorder characterized by involvement of the skeleton and central nervous system.

Case

We report the case of a 5-year-old girl who had LNSS with hypophosphatemic rickets and multiple fractures of her extremities. Biochemical tests revealed a high serum level of fibroblast growth factor-23 (FGF-23) but normal levels of immunoglobulin E (IgE) and parathormone (PTH). FGF-23 mRNA expression in the skin lesions of our patient’s skin was found to be below the limit of detection in all samples tested by quantitative-PCR analysis.

Conclusions

It is possible that an as-yet unidentified substance increases FGF-23 expression LNS lesions.

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Title: Linear nevus sebaceous syndrome with hypophosphatemic rickets with elevated FGF-23
Authors: Ryo Narazaki
Kenji Ihara
Noriyuki Namba
Hiroshi Matsuzaki
Keiichi Ozono
Toshiro Hara
Publication date: 01-05-2012
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 5/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-2086-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Linear nevus sebaceous syndrome with hypophosphatemic rickets with elevated FGF-23

Abstract

Background

Case

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case

Conclusions

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