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01-11-2011 | Original Article

Urine IL-8 concentrations in infectious and non-infectious urinary tract conditions

Authors: Maria Bitsori, Maria Karatzi, Helen Dimitriou, Eleni Christakou, Avrora Savvidou, Emmanouil Galanakis

Published in: Pediatric Nephrology | Issue 11/2011

Abstract

Urine IL-8 concentrations are known to be elevated in urinary tract infection (UTI), as well as in vesicoureteral reflux (VUR) even in the absence of infection. In this study we further investigated urine IL-8 in infants with congenital anomalies of the kidneys and urinary tract and with antenatally diagnosed isolated pelvic dilatation. Urine IL-8 was measured in 159 infants aged 1 month to 1 year with acute UTI (group A, n = 26), resolved UTI (group B, n = 16), VUR without recent UTI (group C, n = 44), non-VUR congenital urinary anomalies without recent UTI (group D, n = 30), isolated antenatal pelvic dilatation (group E, n = 14) and in infants without known urinary tract condition (control group F, n = 29). Median values of urine IL-8/creatinine levels were 61.5, 4.64, 15.5, 14.3, 1.06 and 4.19 pg/μmol in groups A, B, C, D, E and F respectively. Compared with the control group, urine IL-8 was elevated in infants with acute UTI, VUR without acute UTI and congenital anomalies without acute UTI (p < 0.0001; p < 0.005; and p = 0.027 respectively), but not in infants with resolved UTI or with antenatal pelvic dilatation. Urine IL-8 levels are elevated in a variety of infectious and non-infectious urinary tract conditions, and hence may serve as a sensitive but not specific screening biomarker of urinary tract diseases.

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Title: Urine IL-8 concentrations in infectious and non-infectious urinary tract conditions
Authors: Maria Bitsori
Maria Karatzi
Helen Dimitriou
Eleni Christakou
Avrora Savvidou
Emmanouil Galanakis
Publication date: 01-11-2011
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 11/2011
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-1909-7

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Urine IL-8 concentrations in infectious and non-infectious urinary tract conditions

Abstract

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