Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Pediatric Nephrology
Published in: Pediatric Nephrology 1/2012

01-01-2012 | Clinical Quiz

An infant with alternating metabolic acidosis and alkalosis: answer

Authors: Nakysa Hooman, Daniel Jafari, Sahar Jalali-Farahani, Arash Lahouti Harahdashti

Published in: Pediatric Nephrology | Issue 1/2012

Login to get access

Excerpt

1.
The sweat chloride test was performed on two separate occasions, which showed chloride levels of 72 and 110 mEq/l. These confirmed the diagnosis of cystic fibrosis (CF), but genetic tests failed to find common mutations of the cystic fibrosis transmembrane regulator (CFTR) gene (delta-F508, W1282X, N1303K, G542X, and G551D).
 
2.
A hypochloremic metabolic alkalosis with low urinary chloride levels on second admission raised the suspicion of CF. It was consistent with the clinical picture of failure to thrive, respiratory infections, and gastrointestinal symptoms.
 
3.
Acute respiratory failure in the first hospitalization could have been coincidental, a result of dehydration or aminoglycoside use, or it may have been related to the diagnosis of CF.
 
…
Literature
1.
Davis PB, di Sant’Agnese PA (1984) Diagnosis and treatment of cystic fibrosis. An update Chest 85:802–809PubMedCrossRef
2.
Salvatore D, Buzzetti R, Baldo E, Forneris MP, Lucidi V, Manunza D, Marinelli I, Messore B, Neri AS, Raia V, Furnari ML, Mastella G (2010) An overview of international literature from cystic fibrosis registries. II. Neonatal screening and nutrition/growth. J Cyst Fibros 9:75–83PubMedCrossRef
3.
Buzzetti R, Salvatore D, Baldo E, Forneris MP, Lucidi V, Manunza D, Marinelli I, Messore B, Neri AS, Raia V, Furnari ML, Mastella G (2009) An overview of international literature from cystic fibrosis registries. I. Mortality and survival studies in cystic fibrosis. J Cyst Fibros 8:229–237PubMedCrossRef
4.
Winter SD (1981) Measurement of urine electrolytes: clinical significance and methods. Crit Rev Clin Lab Sci 14:163–187PubMedCrossRef
5.
Quinton PM (2007) Cystic fibrosis: lessons from the sweat gland. Physiology (Bethesda) 22:212–225CrossRef
6.
Agnarsson U, Glass S, Govan JR (1989) Fecal isolation of Pseudomonas aeruginosa from patients with cystic fibrosis. J Clin Microbiol 27:96–98PubMed
7.
8.
Patzer L (2008) Nephrotoxicity as a cause of acute kidney injury in children. Pediatr Nephrol 23:2159–2173PubMedCrossRef
9.
Bockenhauer D, Hug MJ, Kleta R (2009) Cystic fibrosis, aminoglycoside treatment and acute renal failure: the not so gentle micin. Pediatr Nephrol 24:925–928PubMedCrossRef
10.
Durante-Mangoni E, Grammatikos A, Utili R, Falagas ME (2009) Do we still need the aminoglycosides? Int J Antimicrob Agents 33:201–205PubMedCrossRef
11.
Drusano GL, Ambrose PG, Bhavnani SM, Bertino JS, Nafziger AN, Louie A (2007) Back to the future: using aminoglycosides again and how to dose them optimally. Clin Infect Dis 45:753–760PubMedCrossRef
12.
Mingeot-Leclercq MP, Tulkens PM (1999) Aminoglycosides: nephrotoxicity. Antimicrob Agents Chemother 43:1003–1012PubMed
13.
Tan KH, Mulheran M, Knox AJ, Smyth AR (2003) Aminoglycoside prescribing and surveillance in cystic fibrosis. Am J Respir Crit Care Med 167:819–823PubMedCrossRef
14.
Pavone MA, Solís Padrones A, Muratore DG, Saiz M, Puig C (2010) Hyponatremia, hypopotassemia and pre-renal acute renal failure as a presentation of cystic fibrosis. Nefrologia 30:481–482PubMed
Metadata
Title
An infant with alternating metabolic acidosis and alkalosis: answer
Authors
Nakysa Hooman
Daniel Jafari
Sahar Jalali-Farahani
Arash Lahouti Harahdashti
Publication date
01-01-2012
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 1/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-011-1901-2

Other articles of this Issue 1/2012

Pediatric Nephrology 1/2012 Go to the issue

Letter to the Editors

Pediatric AKI leads to CKD—the authors respond

Original Article

Longitudinal study of bone mineral density in children with idiopathic hypercalciuria

Original Article

Age-related changes in expression in renal AQPs in response to congenital, partial, unilateral ureteral obstruction in rats

Erratum

Erratum to: Hypertension in infancy: diagnosis, management and outcome

Original Article

Genetic basis of cystinosis in Turkish patients: a single-center experience

Original Article

Clinical presentation and metabolic features of overt and occult urolithiasis