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01-09-2011 | Review

Kidney and urinary tract development: an apoptotic balancing act

Authors: Katherine Stewart, Maxime Bouchard

Published in: Pediatric Nephrology | Issue 9/2011

Abstract

Development of the mammalian urogenital system requires a balance between survival and programmed cell death. Pro-survival molecules are crucial in preserving metanephric mesenchyme viability, and thus allowing nephrogenesis to proceed. At the same time, localized areas of apoptosis mediated by effector caspases are required for the appropriate morphogenesis of the kidney and urinary tract. Activation of the intrinsic pathway of apoptosis seems to be fundamental to the progression of cell death necessary to aid ureteric bud branching, nephrogenesis, and ureter-bladder connection. Here, we review what is currently known about survival and apoptosis in building functional kidneys and urinary tracts.

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Title: Kidney and urinary tract development: an apoptotic balancing act
Authors: Katherine Stewart
Maxime Bouchard
Publication date: 01-09-2011
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 9/2011
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-1788-y

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Springer Medicine

Kidney and urinary tract development: an apoptotic balancing act

Abstract

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Springer Medicine

Abstract

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