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Pediatric Nephrology
Published in: Pediatric Nephrology 4/2011

01-04-2011 | Review

Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues

Authors: Umberto Simeoni, Isabelle Ligi, Christophe Buffat, Farid Boubred

Published in: Pediatric Nephrology | Issue 4/2011

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Abstract

Epidemiological and experimental studies show that the risk of cardiovascular and metabolic diseases at adulthood is inversely related to the weight at birth. Although with less evidence, low birth weight has been suggested to increase the risk of chronic kidney disease (CKD). It is well established that the developmental programming of arterial hypertension and of renal disease involves in particular renal factors, especially nephron endowment, which is reduced in low birth weight and maternal diabetes situations. Experimental studies, especially in rodents, have demonstrated the long-term influence of postnatal nutrition and/or postnatal growth on cardiovascular, metabolic and renal functions, while human data are scarce on this issue. Vascular and renal diseases appear to have a “multihits” origin, with reduced nephron number the initial hit and rapid postnatal growth the second hit. This review addresses the current understanding of the role of the kidney, both as a mechanism and as a target, in the developmental origins of adult disease theory, with a particular focus on the long-term effects of postnatal growth and nutrition.
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Metadata
Title
Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues
Authors
Umberto Simeoni
Isabelle Ligi
Christophe Buffat
Farid Boubred
Publication date
01-04-2011
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 4/2011
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-010-1648-1

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