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01-09-2009 | Brief Report

Fatal pulmonary fibrosis after rituximab administration

Authors: Marie-Camille Chaumais, Arnaud Garnier, François Chalard, Michel Peuchmaur, Stephane Dauger, Evelyne Jacqz-Agrain, Georges Deschênes

Published in: Pediatric Nephrology | Issue 9/2009

Abstract

Idiopathic nephrotic syndrome is the most frequent glomerular disease during childhood. Although immunosuppressive agents are usually effective, some severe cases remain difficult to treat. We describe a female patient with secondary steroid-resistant nephrotic syndrome who no longer responded to conventional treatment. Owing to cyclosporine toxicity, rituximab was administered. Three days after treatment the patient’s clinical condition dramatically worsened and she developed acute respiratory distress. Despite all means used to treat her, she died 5 weeks after rituximab infusion. A pulmonary biopsy showed extensive fibrosis, while the alveolar epithelium was no longer visible.

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Title: Fatal pulmonary fibrosis after rituximab administration
Authors: Marie-Camille Chaumais
Arnaud Garnier
François Chalard
Michel Peuchmaur
Stephane Dauger
Evelyne Jacqz-Agrain
Georges Deschênes
Publication date: 01-09-2009
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 9/2009
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-009-1195-9

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Fatal pulmonary fibrosis after rituximab administration

Abstract

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Abstract

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