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01-08-2009 | Brief Report

Fibrillary glomerulonephritis and renal failure in a child with systemic lupus erythematosus

Authors: Shina Menon, Xu Zeng, Rudolph Valentini

Published in: Pediatric Nephrology | Issue 8/2009

Abstract

Fibrillary glomerulonephritis (FGN) is a rare immune-mediated glomerulopathy characterized by randomly arranged immunoglobulin (Ig) deposits on electron microscopy. Only seven pediatric cases have been reported, and the incidence in adults is about 1.5%. A 12-year-old boy presented with systemic lupus erythematosus (SLE) with World Health Organization Class IV lupus nephritis. A repeat biopsy carried out due to a poor response to standard immunosuppressive therapy and worsening renal functions revealed diffuse proliferative glomerulonephritis with fibrillary deposits. Despite aggressive immunosuppression with plasmapheresis and rituximab, the patient developed end stage renal disease. This is an atypical pediatric case characterized by SLE-associated FGN and a poor prognosis.

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Title: Fibrillary glomerulonephritis and renal failure in a child with systemic lupus erythematosus
Authors: Shina Menon
Xu Zeng
Rudolph Valentini
Publication date: 01-08-2009
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 8/2009
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-009-1168-z

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Fibrillary glomerulonephritis and renal failure in a child with systemic lupus erythematosus

Abstract

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Abstract

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