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01-04-2009 | Brief Report

Oxidative imbalance in idiopathic renal hypouricemia

Authors: Kazunari Kaneko, Naho Taniguchi, Yuko Tanabe, Takahide Nakano, Masafumi Hasui, Kandai Nozu

Published in: Pediatric Nephrology | Issue 4/2009

Abstract

An important complication of idiopathic renal hypouricemia is exercise-induced acute renal failure (ARF). The most plausible explanation for this complication is that decreased antioxidant potential leads to kidney injury by reactive oxygen species (ROS). We demonstrated this oxidative imbalance by a concomitant assessment of ROS production and antioxidant system capability in a 15- year-old girl with idiopathic renal hypouricemia caused by a mutation in the urate transporter (URAT1) gene. Her serum level of ROS increased with decreasing antioxidant potential capacity soon after the initiation of anaerobic stress due to treadmill exercise. Thereafter, serum levels of ROS and antioxidant potential showed a parallel course, returning to the baseline values at 240 min after exercise. Some patients with idiopathic renal hypouricemia demonstrate oxidative imbalance soon after exercise with a predisposition to exercise-induced acute renal failure. Antioxidant properties may alter this imbalance by augmenting the antioxidant activity.

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Title: Oxidative imbalance in idiopathic renal hypouricemia
Authors: Kazunari Kaneko
Naho Taniguchi
Yuko Tanabe
Takahide Nakano
Masafumi Hasui
Kandai Nozu
Publication date: 01-04-2009
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 4/2009
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-008-1032-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Oxidative imbalance in idiopathic renal hypouricemia

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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