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01-11-2008 | Original Article

Doppler assessment of brachial artery flow as a measure of endothelial dysfunction in pediatric chronic renal failure

Authors: Gehan Hussein, Yasser Bughdady, Manal E. Kandil, Hafez M. Bazaraa, Heba Taher

Published in: Pediatric Nephrology | Issue 11/2008

Abstract

Cardiovascular morbidity and mortality are highly prevalent among patients with chronic renal failure (CRF). Endothelial dysfunction is regarded as the initial reversible step in the development of atherosclerosis and has been demonstrated in all stages of renal failure. Non-invasive techniques to assess endothelial function have been recently developed and have been proven to predict future mortality in adults. We aimed to assess endothelial function in children with stage 4 chronic kidney disease (CKD 4) on conservative treatment, using a-non invasive, high-resolution, ultrasound Doppler study of the brachial artery flow, correlating it with other clinical and laboratory parameters. This study included 34 children with CKD 4 on conservative treatment who were compared with 30 healthy controls. Flow-mediated dilatation (FMD), nitroglycerin-mediated dilatation (NTG-MD) and FMD/NTG-MD ratio were estimated. FMD was abnormal (< 5%) in 24 patients (71%). FMD and FMD/NTG-MD ratio were significantly lower in patients than in controls (P = 0.001 and P = 0.01, respectively). FMD correlated positively with serum calcium and negatively with alkaline phosphatase. We concluded that endothelial dysfunction is present in children with CKD 4 on conservative treatment and may reflect increased atherogenic and thrombogenic properties of the endothelium, contributing to subsequent adverse cardiovascular outcome.

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Title: Doppler assessment of brachial artery flow as a measure of endothelial dysfunction in pediatric chronic renal failure
Authors: Gehan Hussein
Yasser Bughdady
Manal E. Kandil
Hafez M. Bazaraa
Heba Taher
Publication date: 01-11-2008
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 11/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-008-0874-2

At a glance: The STEP trials

Springer Medicine

Doppler assessment of brachial artery flow as a measure of endothelial dysfunction in pediatric chronic renal failure

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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