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01-09-2008 | Review

Slowing chronic kidney disease progression: results of prospective clinical trials in adults

Authors: Thai Nguyen, Robert D. Toto

Published in: Pediatric Nephrology | Issue 9/2008

Abstract

Chronic kidney disease is generally thought to be a progressive disorder regardless of etiology. Over the past 15 years, investigations into the mechanisms of disease progression and treatment designed to slow or halt disease progression have been conducted, largely in the adult kidney disease population. Intervention trials have demonstrated that lowering blood pressure in hypertensive patients and administration of drugs that block the renin–angiotensin aldosterone system are effective at slowing kidney disease progression, including diabetes, hypertension, and various glomerular diseases. In addition, novel strategies including anemia therapy with erythropoietin-stimulating agents have been conducted to determine whether treatment of this common complication of kidney disease can stabilize kidney function. Whereas substantial success has been achieved in more common forms of adult kidney disease such as diabetes and hypertension, slowing progression of some immune-mediated glomerular disease such as lupus nephritis and immunoglobulin A (IgA) nephropathy remain a great challenge. Moreover, there is no proven strategy, including multifactorial interventions, that clearly halts progressive chronic kidney disease that has been studied prospectively in a large-scale, long-term trial. The purpose of this review is to discuss these trials, as they form the underpinnings for current clinical practice guidelines in adults with chronic kidney disease.

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Title: Slowing chronic kidney disease progression: results of prospective clinical trials in adults
Authors: Thai Nguyen
Robert D. Toto
Publication date: 01-09-2008
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 9/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0737-2

At a glance: The STEP trials

Springer Medicine

Slowing chronic kidney disease progression: results of prospective clinical trials in adults

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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