Top

Published in:

Open Access 01-02-2008 | Brief Report

Growth hormone producing prolactinoma in juvenile cystinosis: a simple coincidence?

Authors: Martine T. P. Besouw, Elena N. Levtchenko, Michèl A. A. P. Willemsen, Kees Noordam

Published in: Pediatric Nephrology | Issue 2/2008

Abstract

Juvenile cystinosis was diagnosed in a patient who presented with severe headache attacks and photophobia. Treatment with oral cysteamine and topical cysteamine eye drops was started. One-and-a-half years later, he developed unilateral gynecomastia and elevated prolactin and growth hormone levels. A pituitary macroprolactinoma was discovered and successfully treated with the dopamine agonist cabergoline. Increased serum growth hormone levels were attributed to enhanced growth hormone production by the prolactinoma and somatostatin inhibition by cysteamine. Although the occurrence of prolactinoma in this patient could be a simple coincidence, it might also be a rare yet unrecognised complication of cystinosis.

Gahl WA, Thoene JG, Schneider JA (2002) Cystinosis. N Engl J Med 347:111–121PubMedCrossRef

Gahl WA, Reed GF, Thoene JG, Schulman JD, Rizzo WB, Jonas AJ, Denman DW, Schlesselman JJ, Corden BJ, Schneider JA (1987) Cysteamine therapy for children with nephropathic cystinosis. N Engl J Med 316:971–977PubMedCrossRef

Webster J, Scanlon MF (1997) Prolactinomas. In: Sheaves R, Jenkins P, Wass J (eds) Clinical endocrine oncology, 1st edn. Blackwell Publishing, London, pp 189–194

Zanettini R, Antonini A, Gatto G, Gentile R, Tesei S, Pezzoli G (2007) Valvular heart disease and the use of dopamine agonists for Parkinson’s disease. N Engl J Med 356:39–46PubMedCrossRef

Broyer M, Tête MJ, Guest G, Bertheleme JP, Labrousse F, Poisson M (1996) Clinical polymorphism of cystinosis encephalopathy. Results of treatment with cysteamine. J Inherit Metab Dis 19:65–75PubMedCrossRef

Bercu BB, Orloff S, Schulman JD (1980) Pituitary resistance to thyroid hormone in cystinosis. J Clin Endocrinol Metab 51:1262–1268PubMed

Ross DL, Strife CF, Towbin R, Bove KE (1982) Nonabsorptive hydrocephalus associated with nephropathic cystinosis. Neurology 32:1330–1334PubMed

Dogulu CF, Tsilou E, Rubin B, FitzGibbon EJ, Kaiser-Kupper MI, Rennert OM, Gahl WA (2004) Idiopathic intracranial hypertension in cystinosis. J Pediatr 145:673–678PubMedCrossRef

Cannavo S, Venturino M, Curtò L, De Menis E, D’Arrigo C, Tita P, Billeci D, Trimarchi F (2003) Clinical presentation and outcome of pituitary adenomas in teenagers. Clin Endocrinol 58:519–527CrossRef

10.

Boggild MD, Jenkinson S, Pistorello M, Boscaro M, Scanarini M, McTernan P, Perrett CW, Thakker RV, Clayton RN (1994) Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab 78:387–392PubMedCrossRef

11.

Gahl WA, Bercu BB (1985) Blunted prolactin response to thyrotropin-releasing hormone stimulation in cystinotic children receiving cysteamine. J Clin Endocrinol Metab 60:793–796PubMed

12.

Lucky AW, Howley PM, Megyesi K, Spielberg SP, Schulman JD (1977) Endocrine studies in cystinosis: compensated primary hypothyroidism. J Pediatr 91:204–210PubMedCrossRef

13.

Gahl WA, Thoene JG, Schneider JA (2001) Cystinosis: a disorder of lysosomal membrane transport. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic & molecular bases of inherited disease, 8th edn. McGraw-Hill, New York, pp 5085–5108

14.

Szabo S, Reichlin S (1981) Somatostatin in rat tissues is depleted by cysteamine administration. Endocrinology 109:2255–2257PubMedCrossRef

15.

Chik CL, Friedman A, Merriam GR, Gahl WA (1993) Pituitary-testicular function in nephropathic cystinosis. Ann Intern Med 119:568–575PubMed

Title: Growth hormone producing prolactinoma in juvenile cystinosis: a simple coincidence?
Authors: Martine T. P. Besouw
Elena N. Levtchenko
Michèl A. A. P. Willemsen
Kees Noordam
Publication date: 01-02-2008
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 2/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0543-x

At a glance: The STEP trials

Springer Medicine

Growth hormone producing prolactinoma in juvenile cystinosis: a simple coincidence?

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2008

Pitfalls in studies of children with monosymptomatic nocturnal enuresis

Influence of N-acetylcysteine on renal toxicity of cadmium in rats

Tolterodine and imipramine in refractory enuresis; a placebo-controlled crossover study

Histochemical and immunohistochemical study of the glomerular development in human fetuses

Anemia in children with chronic kidney disease

Reversible acute fetal renal failure due to maternal exposure to angiotensin receptor blocker