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01-11-2007 | Educational Feature

Glomerular filtration rate measurement and estimation in chronic kidney disease

Authors: George J. Schwartz, Susan L. Furth

Published in: Pediatric Nephrology | Issue 11/2007

Abstract

Glomerular filtration rate (GFR) assesses kidney function. GFR is measured by renal clearance techniques; inulin clearance is the gold standard but is not easily measured. Thus, other methods to determine GFR have been utilized. Endogenous creatinine clearance (CrCl) is the most widely used, but creatinine secretion falsely elevates GFR. Cimetidine inhibits creatinine secretion, such that CrCl equals GFR, provided there are no difficulties with bladder emptying. Estimation of GFR from serum creatinine (e.g. Schwartz formula) is useful clinically; however, such formulae have not been updated for enzymatic creatinine autoanalyzers. Cystatin C, a small protein, is produced at a relatively constant rate and is reabsorbed in the proximal tubule. Cystatin C may be more sensitive than creatinine in detecting a reduction in GFR, but further studies are needed to prove this. Single injection (plasma) clearance techniques are the most precise measures of GFR. Iohexol is an exogenous marker that is comparable to inulin and ⁵¹Cr-EDTA and can be measured by high-performance liquid chromatography (HPLC). Our pilot and the Chronic Kidney Disease in Children (CKiD) North American studies show that iohexol can accurately measure GFR using a four-point plasma disappearance curve national studies show that iohexol can accurately measure GFR using a four-point plasma disappearance curve (10, 30, 120, and 300 min) or, in most cases, a two-point disappearance time (120 and 300 min).

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Title: Glomerular filtration rate measurement and estimation in chronic kidney disease
Authors: George J. Schwartz
Susan L. Furth
Publication date: 01-11-2007
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 11/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-006-0358-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Glomerular filtration rate measurement and estimation in chronic kidney disease

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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