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01-06-2005 | Original Article

Association of vitamin-D and calcitonin receptor gene polymorphism in paediatric nephrolithiasis

Authors: Hemant Kumar Bid, Himanshu Chaudhary, Rama Devi Mittal

Published in: Pediatric Nephrology | Issue 6/2005

Abstract

We investigated the role of vitamin-D receptor gene (VDR) and calcitonin receptor (CTR) gene polymorphism in childhood nephrolithiasis in the north Indian population. A control group of 60 healthy paediatric individuals (age range 4−16 years) and 50 paediatric patients (age range 2–14 years) with kidney stones were examined. Polymorphism in both genes (VDR and CTR) was detected by using PCR-based restriction analysis. There was a statistically significant difference between the two groups for the genotypes of the VDR gene Fok-I polymorphism (P =0.007) and the CTR gene (P =0.048) polymorphism. The odds ratio (95% Confidence Interval) for the C allele in those at risk of stone disease was 1.83 (0.82–4.09) in VDR gene polymorphism and 1.99 (0.90–4.39) in the case of CTR gene polymorphism. Our results suggest that the effects of VDR (Fok-I) and CTR gene polymorphism contribute to the understanding of the pathogenesis of urinary calculi. It is also suggestive of a potential candidate gene in the search for genetic causes of paediatric calcium oxalate nephrolithiasis.

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Title: Association of vitamin-D and calcitonin receptor gene polymorphism in paediatric nephrolithiasis
Authors: Hemant Kumar Bid
Himanshu Chaudhary
Rama Devi Mittal
Publication date: 01-06-2005
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 6/2005
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-005-1846-4

At a glance: The STEP trials

Springer Medicine

Association of vitamin-D and calcitonin receptor gene polymorphism in paediatric nephrolithiasis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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