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Pediatric Nephrology
Published in: Pediatric Nephrology 9/2004

01-09-2004 | Original Article

Co-administration of cyclosporine and ketoconazole in idiopathic childhood nephrosis

Authors: Amr El-Husseini, Fathy El-Basuony, Ihab Mahmoud, Ahmed Donia, Nabil Hassan, Nagy Sayed-Ahmad, Mohamed Sobh

Published in: Pediatric Nephrology | Issue 9/2004

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Abstract

The concomitant use of cyclosporine (CsA) and ketoconazole (keto) in children with nephrotic syndrome (NS) has never been reported in the literature. This retrospective cohort study was conducted to investigate cost saving, safety, and efficacy of co-administration of keto and CsA in children with NS. The study included 186 nephrotic children receiving CsA therapy. Most were steroid dependent or resistant, and the most common pathology was focal segmental glomerulosclerosis (62%). Among our patients, 137 received daily keto therapy (keto group) 50 mg/day in addition to CsA, while 49 received CsA alone (non-keto group). The characteristics of both groups were comparable and the mean (±SD) duration of treatment was 22.9 ± 8.1 months. Co-administration of keto significantly reduced the mean dose of CsA with an overall net cost saving of 37%. It also resulted in a significant improvement of CsA response, more successful steroid withdrawal, and decreased the frequency of renal impairment. Keto was generally well tolerated and safe. We conclude that co-administration of low-dose keto with CsA in children with idiopathic NS is safe, significantly reduces the cost of CsA therapy, and may improve the patient outcome.
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Metadata
Title
Co-administration of cyclosporine and ketoconazole in idiopathic childhood nephrosis
Authors
Amr El-Husseini
Fathy El-Basuony
Ihab Mahmoud
Ahmed Donia
Nabil Hassan
Nagy Sayed-Ahmad
Mohamed Sobh
Publication date
01-09-2004
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 9/2004
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-004-1545-6

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