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Pediatric Nephrology
Published in: Pediatric Nephrology 9/2004

01-09-2004 | Original Article

Kidney growth in 717 healthy children aged 0–18 months: a longitudinal cohort study

Authors: Ida M. Schmidt, Katharina M. Main, Ida N. Damgaard, Claudia Mau, Anna-Maarit Haavisto, Marla Chellakooty, Kirsten A. Boisen, Jørgen H. Petersen, Thomas Scheike, Klaus Olgaard

Published in: Pediatric Nephrology | Issue 9/2004

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Abstract

Kidney size is an important parameter in the evaluation of children with renal disease. However, reference materials for kidney size in healthy children have been limited beyond the neonatal period. We performed a longitudinal cohort study of 717 healthy children born at term with normal birth weight. Kidney size and shape were determined by ultrasonography and related to gender, age, and body size (weight, length, body surface area, skinfold thickness) at 0, 3, and 18 months of age. Gender-differentiated reference charts were established. Boys had significantly larger kidney volumes than girls (P<0.001) and larger relative volumes (kidney volume/weight) at 0 and 3 months (P<0.001), but not at 18 months of age. The best single predictor of gender-differentiated kidney volume was weight. Relative kidney volume changed with increasing age and height in a two-phase pattern: an initial decrease until a height of 65–70 cm was reached followed by a stable level. In conclusion, kidney size was significantly influenced by gender, age, and body composition. Relative kidney volume decreased with increasing age and height in a two-phase pattern. These characteristic changes in kidney volume indicated that infant kidney growth might be influenced by sex steroids and growth hormone in addition to body composition.
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Metadata
Title
Kidney growth in 717 healthy children aged 0–18 months: a longitudinal cohort study
Authors
Ida M. Schmidt
Katharina M. Main
Ida N. Damgaard
Claudia Mau
Anna-Maarit Haavisto
Marla Chellakooty
Kirsten A. Boisen
Jørgen H. Petersen
Thomas Scheike
Klaus Olgaard
Publication date
01-09-2004
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 9/2004
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-004-1479-z

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