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Pediatric Nephrology
Published in: Pediatric Nephrology 5/2003

01-05-2003 | Original Article

Adrenomedullin and nitric oxide in children with detrusor instability

Authors: Ayşe Balat, Kemal Sarıca, Mustafa Çekmen, Muhittin Yürekli, Faruk Yağcı, Ahmet Erbağcı

Published in: Pediatric Nephrology | Issue 5/2003

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Abstract.

Detrusor instability (DI) and detrusor-external sphincter dyssynergia lead to poor bladder emptying and high bladder pressure. Recent results indicate that nitric oxide (NO) is an important transmitter or messenger molecule in autonomic neurotransmission. Adrenomedullin (AM) is a potent vasodilator and natriuretic peptide, originally purified from human pheochromocytoma. Since NO and AM have vasodilatory effects on smooth muscles, we considered them to be of interest in children with DI. We determined the tissue levels of NO and AM in 14 children with DI, and compared these with 6 children with normal bladder activity. Bladder biopsy total nitrite levels (nmol/g tissue) were decreased in children with DI (10.69±0.91 vs. 12.83±0.98, P<0.01). However, AM levels (pmol/g tissue) were increased in the same patients (48.84±3.52 vs. 28.79±1.53, P<0.001). According to our results, decreased NO production probably has a role in the pathophysiology of DI, although increased AM appears to be compensatory. NO may provide a therapeutic target in clinical situations related to DI. However, the functional significance of AM and NO in bladder smooth muscle remains to be determined by further detailed studies.
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Metadata
Title
Adrenomedullin and nitric oxide in children with detrusor instability
Authors
Ayşe Balat
Kemal Sarıca
Mustafa Çekmen
Muhittin Yürekli
Faruk Yağcı
Ahmet Erbağcı
Publication date
01-05-2003
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 5/2003
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-003-1125-1

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