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Pediatric Nephrology
Published in: Pediatric Nephrology 5/2003

01-05-2003 | Brief Report

Cerebral aspergillosis in an infant with corticosteroid-resistant nephrotic syndrome

Authors: Emmanuel Roilides, Efterpi Pavlidou, Frantzis Papadopoulos, Christos Panteliadis, Evangelia Farmaki, Maria Tamiolaki, John Sotiriou

Published in: Pediatric Nephrology | Issue 5/2003

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Abstract.

Cerebral aspergillosis is a devastating disease in patients with a compromised immune system. A unique case of a male infant with corticosteroid-resistant nephrotic syndrome complicated by pulmonary and cerebral aspergillosis is described. The patient rapidly developed coma and neurological symptoms and died soon thereafter. Central nervous system aspergillosis was diagnosed radiologically and by detection of Aspergillus DNA and antigen (galactomannan) in blood and cerebrospinal fluid. Moderate immunosuppressive therapy and antifungal phagocytic dysfunction due to nephrotic syndrome per se may have contributed to the occurrence of invasive aspergillosis in our patient. Awareness of this serious complication and early application of diagnostic procedures and antifungal therapy may improve the dismal outcome.
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Metadata
Title
Cerebral aspergillosis in an infant with corticosteroid-resistant nephrotic syndrome
Authors
Emmanuel Roilides
Efterpi Pavlidou
Frantzis Papadopoulos
Christos Panteliadis
Evangelia Farmaki
Maria Tamiolaki
John Sotiriou
Publication date
01-05-2003
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 5/2003
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-003-1113-5

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