Skip to main content
Top
Published in: Surgical Endoscopy 10/2020

01-10-2020 | Colon Cancer

Colonic splenic flexure carcinoma: is laparoscopic segmental resection a safe enough oncological approach?

Authors: Massimiliano Ardu, Carlo Bergamini, Jacopo Martellucci, Paolo Prosperi, Andrea Valeri

Published in: Surgical Endoscopy | Issue 10/2020

Login to get access

Abstract

Background

The surgical approach to the colonic splenic flexure cancer (SFC) is yet to be technically standardized. The aim of this study has been to retrospectively evaluate the oncologic long-term results of our cases comparing our data with other authors’ experiences.

Methods

Clinical data of patients with SFC operated on at our institute were retrospectively analyzed. The laparoscopic approach was used in the whole series, with limited resection distally and proximally to splenic flexure and the origin ligation of left colic artery and left branch of middle colic artery. Data on the oncological long-term safety were compared to our laparoscopic series of extended right colectomy for proximal two-third transverse colon cancer and high anterior resections for sigmoid-high rectal cancer and to the main evidences in the literature, found after a comprehensive review.

Results

From March 2008 to May 2018, we completed 53 laparoscopic splenic flexure resections (26 female and 27 male, age 71.5 ± 15.4 years). The conversion rate was 3.8%. Most of the cases were stage II (pT3 73.5%, the mean number of lymph nodes harvested was 19.1, with positivity for malignancy in 45.3%). During the FU (43.5 months), 2 patients dropped out. Out of the 51 residual cases, 37 were alive (72.5%) and 14 are deceased (27.5%).

Discussion

Compared to the literature, our survival rate does not show significant differences. The other oncological outcomes seem to be comparable with the data evaluated.

Conclusions

More extended resections seem not to confer an increase of the overall survival rate.
Literature
1.
go back to reference Boyle P, Langman JS (2000) ABC of colorectal cancer: epidemiology. BMJ 321:805–808CrossRef Boyle P, Langman JS (2000) ABC of colorectal cancer: epidemiology. BMJ 321:805–808CrossRef
2.
go back to reference Steffen C, Bokey EL, Chapuis PH (1987) Carcinoma of the splenic flexure. Dis Colon Rectum 30:872–874CrossRef Steffen C, Bokey EL, Chapuis PH (1987) Carcinoma of the splenic flexure. Dis Colon Rectum 30:872–874CrossRef
3.
go back to reference Pisani Ceretti A, Maroni N, Sacchi M, Bona S, Angiolini MR, Bianchi P, Opocher E, Montorsi M (2015) Laparoscopic colonic resection for splenic flexure cancer: our experience. BMC Gastroenterol 15:76CrossRef Pisani Ceretti A, Maroni N, Sacchi M, Bona S, Angiolini MR, Bianchi P, Opocher E, Montorsi M (2015) Laparoscopic colonic resection for splenic flexure cancer: our experience. BMC Gastroenterol 15:76CrossRef
4.
go back to reference McGory ML, Zingmond DS, Sekeris E, Ko CY (2007) The significance of inadvertent splenectomy during colorectal cancer resection. Arch Surg 142:668–674CrossRef McGory ML, Zingmond DS, Sekeris E, Ko CY (2007) The significance of inadvertent splenectomy during colorectal cancer resection. Arch Surg 142:668–674CrossRef
5.
go back to reference Rao TUM, Reddy BS, Chilukoti S (2017) Splenic flexure cancer optimum level of vessel ligation. Int Surg J 4:1355–1359CrossRef Rao TUM, Reddy BS, Chilukoti S (2017) Splenic flexure cancer optimum level of vessel ligation. Int Surg J 4:1355–1359CrossRef
6.
go back to reference Matsuda T, Iwasaki T, Sumi Y, Yamashita K, Hasegawa H, Yamamoto M, Matsuda Y, Kanaji S, Oshikiri T, Nakamura T, Suzuki S, Kakeji Y (2017) Laparoscopic complete mesocolic excision for right-sided colon cancer using a cranial approach: anatomical and embryological consideration. Int J Colorectal Dis 32:139–141CrossRef Matsuda T, Iwasaki T, Sumi Y, Yamashita K, Hasegawa H, Yamamoto M, Matsuda Y, Kanaji S, Oshikiri T, Nakamura T, Suzuki S, Kakeji Y (2017) Laparoscopic complete mesocolic excision for right-sided colon cancer using a cranial approach: anatomical and embryological consideration. Int J Colorectal Dis 32:139–141CrossRef
7.
go back to reference Rusu MC, Vlad M, Voinea LM, Curca GC, Sisu AM (2008) Detailed anatomy of a left accessory aberrant colic artery. Surg Radiol Anat 30:595–599CrossRef Rusu MC, Vlad M, Voinea LM, Curca GC, Sisu AM (2008) Detailed anatomy of a left accessory aberrant colic artery. Surg Radiol Anat 30:595–599CrossRef
8.
go back to reference Hamabe A, Park S, Morita S, Tanida T, Tomimaru Y, Imamura H, Dono K (2018) Analysis of the vascular interrelationships among the first jejunal vein, the superior mesenteric artery, and the middle colic artery. Ann Surg Oncol 25:1661–1667CrossRef Hamabe A, Park S, Morita S, Tanida T, Tomimaru Y, Imamura H, Dono K (2018) Analysis of the vascular interrelationships among the first jejunal vein, the superior mesenteric artery, and the middle colic artery. Ann Surg Oncol 25:1661–1667CrossRef
9.
go back to reference Nakagoe T, Sawai T, Tsuji T, Jibiki M, Ohbatake M, Nanashima A, Yamaguchi H, Yasutake T, Kurosaki N, Ayabe H, Ishikawa H (2001) Surgical treatment and subsequent outcome of patients with carcinoma of the splenic flexure. Surg Today 31:204–209CrossRef Nakagoe T, Sawai T, Tsuji T, Jibiki M, Ohbatake M, Nanashima A, Yamaguchi H, Yasutake T, Kurosaki N, Ayabe H, Ishikawa H (2001) Surgical treatment and subsequent outcome of patients with carcinoma of the splenic flexure. Surg Today 31:204–209CrossRef
10.
go back to reference de’Angelis N, Hain E, Disabato M, Cordun C, Carra MC, Azoulay D, Brunetti F (2016) Laparoscopic extended right colectomy versus laparoscopic left colectomy for carcinoma of the splenic flexure: a matched case-control study. Int J Colorectal Dis 31:623–630CrossRef de’Angelis N, Hain E, Disabato M, Cordun C, Carra MC, Azoulay D, Brunetti F (2016) Laparoscopic extended right colectomy versus laparoscopic left colectomy for carcinoma of the splenic flexure: a matched case-control study. Int J Colorectal Dis 31:623–630CrossRef
11.
go back to reference Okuda J, Yamamoto M, Tanaka K, Masubuchi S, Uchiyama K (2016) Laparoscopic resection of transverse colon cancer at splenic flexure: technical aspects and results. Updates Surg 68:71–75CrossRef Okuda J, Yamamoto M, Tanaka K, Masubuchi S, Uchiyama K (2016) Laparoscopic resection of transverse colon cancer at splenic flexure: technical aspects and results. Updates Surg 68:71–75CrossRef
12.
go back to reference Carlini M, Spoletini D, Castaldi F, Giovannini C, Passaro U (2016) Laparoscopic resection of splenic flexure tumors. Updates Surg 68:77–83CrossRef Carlini M, Spoletini D, Castaldi F, Giovannini C, Passaro U (2016) Laparoscopic resection of splenic flexure tumors. Updates Surg 68:77–83CrossRef
13.
go back to reference Kim MK, Lee IK, Kang WK, Cho HM, Kye BH, Jalloun HE, Kim JG (2017) Long-term oncologic outcomes of laparoscopic surgery for splenic flexure colon cancer are comparable to conventional open surgery. Ann Surg Treat Res 93:35–42CrossRef Kim MK, Lee IK, Kang WK, Cho HM, Kye BH, Jalloun HE, Kim JG (2017) Long-term oncologic outcomes of laparoscopic surgery for splenic flexure colon cancer are comparable to conventional open surgery. Ann Surg Treat Res 93:35–42CrossRef
14.
go back to reference Nakashima M, Akiyoshi T, Ueno M, Fukunaga Y, Nagayama S, Fujimoto Y, Konishi T, Noaki R, Yamakawa K, Nagasue Y, Kuroyanagi H, Yamaguchi T (2011) Colon cancer in the splenic flexure: comparison of short-term outcomes of laparoscopic and open colectomy. Surg Laparosc Endosc Percutan Tech 21:415–418CrossRef Nakashima M, Akiyoshi T, Ueno M, Fukunaga Y, Nagayama S, Fujimoto Y, Konishi T, Noaki R, Yamakawa K, Nagasue Y, Kuroyanagi H, Yamaguchi T (2011) Colon cancer in the splenic flexure: comparison of short-term outcomes of laparoscopic and open colectomy. Surg Laparosc Endosc Percutan Tech 21:415–418CrossRef
15.
go back to reference Han KS, Choi GS, Park JS, Kim HJ, Park SY, Jun SH (2010) Short-term outcomes of a laparoscopic left hemicolectomy for descending colon cancer: retrospective comparison with an open left hemicolectomy. J Korean Soc Coloproctol 26:347–353CrossRef Han KS, Choi GS, Park JS, Kim HJ, Park SY, Jun SH (2010) Short-term outcomes of a laparoscopic left hemicolectomy for descending colon cancer: retrospective comparison with an open left hemicolectomy. J Korean Soc Coloproctol 26:347–353CrossRef
16.
go back to reference Evans MD, Barton K, Rees A, Stamatakis JD, Karandikar SS (2008) The impact of surgeon and pathologist on lymph node retrieval in colorectal cancer and its impact on survival for patients with Dukes’ stage B disease. Colorectal Dis 10:157–164PubMed Evans MD, Barton K, Rees A, Stamatakis JD, Karandikar SS (2008) The impact of surgeon and pathologist on lymph node retrieval in colorectal cancer and its impact on survival for patients with Dukes’ stage B disease. Colorectal Dis 10:157–164PubMed
17.
go back to reference Watanabe J, Ota M, Suwa Y, Ishibe A, Masui H, Nagahori K (2017) Evaluation of lymph flow patterns in splenic flexural colon cancers using laparoscopic real-time indocyanine green fluorescence imaging. Int J Colorectal Dis 32:201–207CrossRef Watanabe J, Ota M, Suwa Y, Ishibe A, Masui H, Nagahori K (2017) Evaluation of lymph flow patterns in splenic flexural colon cancers using laparoscopic real-time indocyanine green fluorescence imaging. Int J Colorectal Dis 32:201–207CrossRef
18.
go back to reference Vasey CE, Rajaratnam S, O’Grady G, Hulme-Moir M (2018) Lymphatic drainage of the splenic flexure defined by intraoperative scintigraphic mapping. Dis Colon Rectum 61:441–446CrossRef Vasey CE, Rajaratnam S, O’Grady G, Hulme-Moir M (2018) Lymphatic drainage of the splenic flexure defined by intraoperative scintigraphic mapping. Dis Colon Rectum 61:441–446CrossRef
19.
go back to reference Odermatt M, Siddiqi N, Johns R, Miskovic D, Khan O, Khan J, Parvaiz A (2014) Short- and long-term outcomes for patients with splenic flexure tumours treated by left versus extended right colectomy are comparable: a retrospective analysis. Surg Today 44:2045–2051CrossRef Odermatt M, Siddiqi N, Johns R, Miskovic D, Khan O, Khan J, Parvaiz A (2014) Short- and long-term outcomes for patients with splenic flexure tumours treated by left versus extended right colectomy are comparable: a retrospective analysis. Surg Today 44:2045–2051CrossRef
20.
go back to reference Currie AC, Brigic A, Thomas-Gibson S, Suzuki N, Moorghen M, Jenkins JT, Faiz OD, Kennedy RH (2017) A pilot study to assess near infrared laparoscopy with indocyanine green (ICG) for intraoperative sentinel lymph node mapping in early colon cancer. Eur J Surg Oncol 43:2044–2051CrossRef Currie AC, Brigic A, Thomas-Gibson S, Suzuki N, Moorghen M, Jenkins JT, Faiz OD, Kennedy RH (2017) A pilot study to assess near infrared laparoscopy with indocyanine green (ICG) for intraoperative sentinel lymph node mapping in early colon cancer. Eur J Surg Oncol 43:2044–2051CrossRef
Metadata
Title
Colonic splenic flexure carcinoma: is laparoscopic segmental resection a safe enough oncological approach?
Authors
Massimiliano Ardu
Carlo Bergamini
Jacopo Martellucci
Paolo Prosperi
Andrea Valeri
Publication date
01-10-2020
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 10/2020
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-019-07221-y

Other articles of this Issue 10/2020

Surgical Endoscopy 10/2020 Go to the issue