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01-02-2019 | New Technology

EUS-guided irreversible electroporation using endoscopic needle-electrode in porcine pancreas

Published in: Surgical Endoscopy | Issue 2/2019

Abstract

Background

Endoscopic irreversible electroporation (IRE) can be performed using a flexible, thin, needle-shaped electrode for an endoscopic ultrasound (EUS)-guided procedure. This study aimed to evaluate the feasibility and efficacy of performing EUS-guided IRE with endoscopic needle-electrode in porcine pancreas.

Methods

Experimental endoscopic IRE on the pancreas were performed by EUS-guided approach in three pigs and compared with surgical approach in three pigs. The animals were killed after 24 h and their pancreases collected.

Results

IRE ablation using endoscopic needle-electrode was successful technically in EUS-guided approaches for the pancreas. Immediately following IRE, the ablated pancreatic tissue showed no gross change except focal hemorrhage. H&E staining presented a well-demarcated ablation site measuring 1.0–1.5 cm in diameter in the pancreas. TUNEL immunohistochemistry showed diffuse cell death along the puncture site 24 h after IRE. No complication was observed in pigs after endoscopic IRE ablation.

Conclusion

EUS-guided IRE ablation was feasible and effective for pancreas using the newly developed device.

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Title: EUS-guided irreversible electroporation using endoscopic needle-electrode in porcine pancreas
Publication date: 01-02-2019
Published in: Surgical Endoscopy / Issue 2/2019
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-018-6425-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

EUS-guided irreversible electroporation using endoscopic needle-electrode in porcine pancreas

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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