Skip to main content
Top
Published in: Surgical Endoscopy 1/2017

01-01-2017 | Review

Warmed and humidified carbon dioxide for abdominal laparoscopic surgery: meta-analysis of the current literature

Authors: David Balayssac, Bruno Pereira, Jean-Etienne Bazin, Bertrand Le Roy, Denis Pezet, Johan Gagnière

Published in: Surgical Endoscopy | Issue 1/2017

Login to get access

Abstract

Background

The creation of a pneumoperitoneum for laparoscopic surgery is performed by the insufflation of carbon dioxide (CO2). The insufflated CO2 is generally at room temperature (20–25 °C) and dry (0–5 % relative humidity). However, these physical characteristics could lead to alterations of the peritoneal cavity, leading to operative and postoperative complications. Warming and humidifying the insufflated gas has been proposed to reduce the iatrogenic effects of laparoscopic surgery, such as pain, hypothermia and peritoneal alterations. Two medical devices are currently available for laparoscopic surgery with warm and humidified CO2.

Methods

Clinical studies were identified by searching PubMed with keywords relating to humidified and warmed CO2 for laparoscopic procedures. Analysis of the literature focused on postoperative pain, analgesic consumption, duration of hospital stay and convalescence, surgical techniques and hypothermia.

Results

Bibliographic analyses reported 114 publications from 1977 to 2015, with only 17 publications of clinical interest. The main disciplines focused on were gynaecological and digestive surgery ). Analysis of the studies selected reported only a small beneficial effect of warmed and humidified laparoscopy compared to standard laparoscopy on immediate postoperative pain and per procedure hypothermia. No difference was observed for later postoperative shoulder pain, morphine equivalent daily doses, postoperative body core temperature, recovery room and hospital length of stay, lens fogging and procedure duration.

Conclusions

Only few beneficial effects on immediate postoperative pain and core temperature have been identified in this meta-analysis. Although more studies are probably needed to close the debate on the real impact of warmed and humidified CO2 for laparoscopic procedures.
Literature
2.
go back to reference Koninckx PR, Vandermeersch E (1991) The persufflator: an insufflation device for laparoscopy and especially for CO2-laser-endoscopic surgery. Hum Reprod Oxf Engl 6:1288–1290 Koninckx PR, Vandermeersch E (1991) The persufflator: an insufflation device for laparoscopy and especially for CO2-laser-endoscopic surgery. Hum Reprod Oxf Engl 6:1288–1290
3.
go back to reference Korell M, Schmaus F, Strowitzki T, Schneeweiss SG, Hepp H (1996) Pain intensity following laparoscopy. Surg Laparosc Endosc 6:375–379CrossRefPubMed Korell M, Schmaus F, Strowitzki T, Schneeweiss SG, Hepp H (1996) Pain intensity following laparoscopy. Surg Laparosc Endosc 6:375–379CrossRefPubMed
4.
go back to reference Ott DE, Reich H, Love B, McCorvey R, Toledo A, Liu CY, Syed R, Kumar K (1998) Reduction of laparoscopic-induced hypothermia, postoperative pain and recovery room length of stay by pre-conditioning gas with the Insuflow device: a prospective randomized controlled multi-center study. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 2:321–329 Ott DE, Reich H, Love B, McCorvey R, Toledo A, Liu CY, Syed R, Kumar K (1998) Reduction of laparoscopic-induced hypothermia, postoperative pain and recovery room length of stay by pre-conditioning gas with the Insuflow device: a prospective randomized controlled multi-center study. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 2:321–329
5.
go back to reference Mouton WG, Bessell JR, Millard SH, Baxter PS, Maddern GJ (1999) A randomized controlled trial assessing the benefit of humidified insufflation gas during laparoscopic surgery. Surg Endosc 13:106–108CrossRefPubMed Mouton WG, Bessell JR, Millard SH, Baxter PS, Maddern GJ (1999) A randomized controlled trial assessing the benefit of humidified insufflation gas during laparoscopic surgery. Surg Endosc 13:106–108CrossRefPubMed
7.
go back to reference Higgins JPT, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JAC, Cochrane Bias Methods Group, Cochrane Statistical Methods Group (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928–d5928. doi:10.1136/bmj.d5928 CrossRefPubMedPubMedCentral Higgins JPT, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JAC, Cochrane Bias Methods Group, Cochrane Statistical Methods Group (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928–d5928. doi:10.​1136/​bmj.​d5928 CrossRefPubMedPubMedCentral
8.
go back to reference Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6:e1000100. doi:10.1371/journal.pmed.1000100 CrossRefPubMedPubMedCentral Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6:e1000100. doi:10.​1371/​journal.​pmed.​1000100 CrossRefPubMedPubMedCentral
10.
go back to reference Almeida OD (2002) Awake microlaparoscopy with the Insuflow device. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 6:199–201 Almeida OD (2002) Awake microlaparoscopy with the Insuflow device. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 6:199–201
11.
go back to reference Benavides R, Wong A, Nguyen H (2009) Improved outcomes for lap-banding using the Insuflow device compared with heated-only gas. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 13:302–305 Benavides R, Wong A, Nguyen H (2009) Improved outcomes for lap-banding using the Insuflow device compared with heated-only gas. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 13:302–305
13.
go back to reference Champion JK, Williams M (2006) Prospective randomized trial of heated humidified versus cold dry carbon dioxide insufflation during laparoscopic gastric bypass. Surg Obes Relat Dis Off J Am Soc Bariatr Surg 2:445–449. doi:10.1016/j.soard.2006.01.013 (discussion 449–450) CrossRef Champion JK, Williams M (2006) Prospective randomized trial of heated humidified versus cold dry carbon dioxide insufflation during laparoscopic gastric bypass. Surg Obes Relat Dis Off J Am Soc Bariatr Surg 2:445–449. doi:10.​1016/​j.​soard.​2006.​01.​013 (discussion 449–450) CrossRef
14.
go back to reference Crabtree JH (2005) Heated, humidified CO2 gas is unsatisfactory for awake laparoscopy. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 9:463–465 Crabtree JH (2005) Heated, humidified CO2 gas is unsatisfactory for awake laparoscopy. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 9:463–465
15.
go back to reference Davis SS, Mikami DJ, Newlin M, Needleman BJ, Barrett MS, Fries R, Larson T, Dundon J, Goldblatt MI, Melvin WS (2006) Heating and humidifying of carbon dioxide during pneumoperitoneum is not indicated: a prospective randomized trial. Surg Endosc 20:153–158. doi:10.1007/s00464-005-0271-x CrossRefPubMed Davis SS, Mikami DJ, Newlin M, Needleman BJ, Barrett MS, Fries R, Larson T, Dundon J, Goldblatt MI, Melvin WS (2006) Heating and humidifying of carbon dioxide during pneumoperitoneum is not indicated: a prospective randomized trial. Surg Endosc 20:153–158. doi:10.​1007/​s00464-005-0271-x CrossRefPubMed
16.
go back to reference Demco L (2001) Effect of heating and humidifying gas on patients undergoing awake laparoscopy. J Am Assoc Gynecol Laparosc 8:247–251CrossRefPubMed Demco L (2001) Effect of heating and humidifying gas on patients undergoing awake laparoscopy. J Am Assoc Gynecol Laparosc 8:247–251CrossRefPubMed
17.
go back to reference Farley DR, Greenlee SM, Larson DR (1960) Harrington JR (2004) Double-blind, prospective, randomized study of warmed, humidified carbon dioxide insufflation vs standard carbon dioxide for patients undergoing laparoscopic cholecystectomy. Arch Surg Chic Ill 139:739–743. doi:10.1001/archsurg.139.7.739 (discussion 743–744) CrossRef Farley DR, Greenlee SM, Larson DR (1960) Harrington JR (2004) Double-blind, prospective, randomized study of warmed, humidified carbon dioxide insufflation vs standard carbon dioxide for patients undergoing laparoscopic cholecystectomy. Arch Surg Chic Ill 139:739–743. doi:10.​1001/​archsurg.​139.​7.​739 (discussion 743–744) CrossRef
18.
go back to reference Hamza MA, Schneider BE, White PF, Recart A, Villegas L, Ogunnaike B, Provost D, Jones D (2005) Heated and humidified insufflation during laparoscopic gastric bypass surgery: effect on temperature, postoperative pain, and recovery outcomes. J Laparoendosc Adv Surg Tech A 15:6–12. doi:10.1089/lap.2005.15.6 CrossRefPubMed Hamza MA, Schneider BE, White PF, Recart A, Villegas L, Ogunnaike B, Provost D, Jones D (2005) Heated and humidified insufflation during laparoscopic gastric bypass surgery: effect on temperature, postoperative pain, and recovery outcomes. J Laparoendosc Adv Surg Tech A 15:6–12. doi:10.​1089/​lap.​2005.​15.​6 CrossRefPubMed
19.
go back to reference Nguyen NT, Furdui G, Fleming NW, Lee SJ, Goldman CD, Singh A, Wolfe BM (2002) Effect of heated and humidified carbon dioxide gas on core temperature and postoperative pain: a randomized trial. Surg Endosc 16:1050–1054. doi:10.1007/s00464-001-8237-0 CrossRefPubMed Nguyen NT, Furdui G, Fleming NW, Lee SJ, Goldman CD, Singh A, Wolfe BM (2002) Effect of heated and humidified carbon dioxide gas on core temperature and postoperative pain: a randomized trial. Surg Endosc 16:1050–1054. doi:10.​1007/​s00464-001-8237-0 CrossRefPubMed
20.
go back to reference Savel RH, Balasubramanya S, Lasheen S, Gaprindashvili T, Arabov E, Fazylov RM, Lazzaro RS, Macura JM (2005) Beneficial effects of humidified, warmed carbon dioxide insufflation during laparoscopic bariatric surgery: a randomized clinical trial. Obes Surg 15:64–69. doi:10.1381/0960892052993530 CrossRefPubMed Savel RH, Balasubramanya S, Lasheen S, Gaprindashvili T, Arabov E, Fazylov RM, Lazzaro RS, Macura JM (2005) Beneficial effects of humidified, warmed carbon dioxide insufflation during laparoscopic bariatric surgery: a randomized clinical trial. Obes Surg 15:64–69. doi:10.​1381/​0960892052993530​ CrossRefPubMed
22.
go back to reference Manwaring JM, Readman E, Maher PJ (2008) The effect of heated humidified carbon dioxide on postoperative pain, core temperature, and recovery times in patients having laparoscopic surgery: a randomized controlled trial. J Minim Invasive Gynecol 15:161–165. doi:10.1016/j.jmig.2007.09.007 CrossRefPubMed Manwaring JM, Readman E, Maher PJ (2008) The effect of heated humidified carbon dioxide on postoperative pain, core temperature, and recovery times in patients having laparoscopic surgery: a randomized controlled trial. J Minim Invasive Gynecol 15:161–165. doi:10.​1016/​j.​jmig.​2007.​09.​007 CrossRefPubMed
24.
go back to reference Yeh CH, Kwok SY, Chan MKY, Tjandra JJ (2007) Prospective, case-matched study of heated and humidified carbon dioxide insufflation in laparoscopic colorectal surgery. Colorectal Dis Off J Assoc Coloproctology G B Irel 9:695–700. doi:10.1111/j.1463-1318.2007.01339.x Yeh CH, Kwok SY, Chan MKY, Tjandra JJ (2007) Prospective, case-matched study of heated and humidified carbon dioxide insufflation in laparoscopic colorectal surgery. Colorectal Dis Off J Assoc Coloproctology G B Irel 9:695–700. doi:10.​1111/​j.​1463-1318.​2007.​01339.​x
26.
go back to reference Klugsberger B, Schreiner M, Rothe A, Haas D, Oppelt P, Shamiyeh A (2014) Warmed, humidified carbon dioxide insufflation versus standard carbon dioxide in laparoscopic cholecystectomy: a double-blinded randomized controlled trial. Surg Endosc 28:2656–2660. doi:10.1007/s00464-014-3522-x CrossRefPubMed Klugsberger B, Schreiner M, Rothe A, Haas D, Oppelt P, Shamiyeh A (2014) Warmed, humidified carbon dioxide insufflation versus standard carbon dioxide in laparoscopic cholecystectomy: a double-blinded randomized controlled trial. Surg Endosc 28:2656–2660. doi:10.​1007/​s00464-014-3522-x CrossRefPubMed
27.
go back to reference Kissler S, Haas M, Strohmeier R, Schmitt H, Rody A, Kaufmann M, Siebzehnruebl E (2004) Effect of humidified and heated CO2 during gynecologic laparoscopic surgery on analgesic requirements and postoperative pain. J Am Assoc Gynecol Laparosc 11:473–477CrossRefPubMed Kissler S, Haas M, Strohmeier R, Schmitt H, Rody A, Kaufmann M, Siebzehnruebl E (2004) Effect of humidified and heated CO2 during gynecologic laparoscopic surgery on analgesic requirements and postoperative pain. J Am Assoc Gynecol Laparosc 11:473–477CrossRefPubMed
28.
29.
go back to reference Neudecker J, Sauerland S, Neugebauer E, Bergamaschi R, Bonjer HJ, Cuschieri A, Fuchs K-H, Jacobi C, Jansen FW, Koivusalo A-M, Lacy A, McMahon MJ, Millat B, Schwenk W (2002) The European Association for Endoscopic Surgery clinical practice guideline on the pneumoperitoneum for laparoscopic surgery. Surg Endosc 16:1121–1143. doi:10.1007/s00464-001-9166-7 CrossRefPubMed Neudecker J, Sauerland S, Neugebauer E, Bergamaschi R, Bonjer HJ, Cuschieri A, Fuchs K-H, Jacobi C, Jansen FW, Koivusalo A-M, Lacy A, McMahon MJ, Millat B, Schwenk W (2002) The European Association for Endoscopic Surgery clinical practice guideline on the pneumoperitoneum for laparoscopic surgery. Surg Endosc 16:1121–1143. doi:10.​1007/​s00464-001-9166-7 CrossRefPubMed
30.
32.
33.
go back to reference Abbott J, Hawe J, Srivastava P, Hunter D, Garry R (2001) Intraperitoneal gas drain to reduce pain after laparoscopy: randomized masked trial. Obstet Gynecol 98:97–100PubMed Abbott J, Hawe J, Srivastava P, Hunter D, Garry R (2001) Intraperitoneal gas drain to reduce pain after laparoscopy: randomized masked trial. Obstet Gynecol 98:97–100PubMed
35.
go back to reference Nguyen NT, Fleming NW, Singh A, Lee SJ, Goldman CD, Wolfe BM (2001) Evaluation of core temperature during laparoscopic and open gastric bypass. Obes Surg 11:570–575CrossRefPubMed Nguyen NT, Fleming NW, Singh A, Lee SJ, Goldman CD, Wolfe BM (2001) Evaluation of core temperature during laparoscopic and open gastric bypass. Obes Surg 11:570–575CrossRefPubMed
36.
go back to reference Bessell JR, Karatassas A, Patterson JR, Jamieson GG, Maddern GJ (1995) Hypothermia induced by laparoscopic insufflation. A randomized study in a pig model. Surg Endosc 9:791–796PubMed Bessell JR, Karatassas A, Patterson JR, Jamieson GG, Maddern GJ (1995) Hypothermia induced by laparoscopic insufflation. A randomized study in a pig model. Surg Endosc 9:791–796PubMed
37.
go back to reference Bessell JR, Ludbrook G, Millard SH, Baxter PS, Ubhi SS, Maddern GJ (1999) Humidified gas prevents hypothermia induced by laparoscopic insufflation: a randomized controlled study in a pig model. Surg Endosc 13:101–105CrossRefPubMed Bessell JR, Ludbrook G, Millard SH, Baxter PS, Ubhi SS, Maddern GJ (1999) Humidified gas prevents hypothermia induced by laparoscopic insufflation: a randomized controlled study in a pig model. Surg Endosc 13:101–105CrossRefPubMed
38.
go back to reference Boelhouwer RU, Bruining HA, Ong GL (1987) Correlations of serum potassium fluctuations with body temperature after major surgery. Crit Care Med 15:310–312CrossRefPubMed Boelhouwer RU, Bruining HA, Ong GL (1987) Correlations of serum potassium fluctuations with body temperature after major surgery. Crit Care Med 15:310–312CrossRefPubMed
39.
go back to reference Ellis PR, Kleinsasser LJ, Speer RJ (1957) Changes in coagulation occurring in dogs during hypothermia and cardiac surgery. Surgery 41:198–210PubMed Ellis PR, Kleinsasser LJ, Speer RJ (1957) Changes in coagulation occurring in dogs during hypothermia and cardiac surgery. Surgery 41:198–210PubMed
40.
go back to reference Frank SM, Fleisher LA, Olson KF, Gorman RB, Higgins MS, Breslow MJ, Sitzmann JV, Beattie C (1995) Multivariate determinants of early postoperative oxygen consumption in elderly patients. Effects of shivering, body temperature, and gender. Anesthesiology 83:241–249CrossRefPubMed Frank SM, Fleisher LA, Olson KF, Gorman RB, Higgins MS, Breslow MJ, Sitzmann JV, Beattie C (1995) Multivariate determinants of early postoperative oxygen consumption in elderly patients. Effects of shivering, body temperature, and gender. Anesthesiology 83:241–249CrossRefPubMed
41.
go back to reference Ralley FE, Wynands JE, Ramsay JG, Carli F, MacSullivan R (1988) The effects of shivering on oxygen consumption and carbon dioxide production in patients rewarming from hypothermic cardiopulmonary bypass. Can J Anaesth J Can Anesth 35:332–337. doi:10.1007/BF03010851 CrossRef Ralley FE, Wynands JE, Ramsay JG, Carli F, MacSullivan R (1988) The effects of shivering on oxygen consumption and carbon dioxide production in patients rewarming from hypothermic cardiopulmonary bypass. Can J Anaesth J Can Anesth 35:332–337. doi:10.​1007/​BF03010851 CrossRef
42.
go back to reference Slotman GJ, Jed EH, Burchard KW (1985) Adverse effects of hypothermia in postoperative patients. Am J Surg 149:495–501CrossRefPubMed Slotman GJ, Jed EH, Burchard KW (1985) Adverse effects of hypothermia in postoperative patients. Am J Surg 149:495–501CrossRefPubMed
43.
go back to reference Kurz A, Sessler DI, Lenhardt R (1996) Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group. N Engl J Med 334:1209–1215. doi:10.1056/NEJM199605093341901 CrossRefPubMed Kurz A, Sessler DI, Lenhardt R (1996) Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group. N Engl J Med 334:1209–1215. doi:10.​1056/​NEJM199605093341​901 CrossRefPubMed
45.
go back to reference Lawrentschuk N, Fleshner NE, Bolton DM (2010) Laparoscopic lens fogging: a review of etiology and methods to maintain a clear visual field. J Endourol Endourol Soc 24:905–913. doi:10.1089/end.2009.0594 CrossRef Lawrentschuk N, Fleshner NE, Bolton DM (2010) Laparoscopic lens fogging: a review of etiology and methods to maintain a clear visual field. J Endourol Endourol Soc 24:905–913. doi:10.​1089/​end.​2009.​0594 CrossRef
46.
go back to reference Almeida OD (2006) Re: JSLS 2005;9: 463-465 Heated, humidified CO2 gas is unsatisfactory for awake laparoscopy. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 10:545 (author reply 545–546) Almeida OD (2006) Re: JSLS 2005;9: 463-465 Heated, humidified CO2 gas is unsatisfactory for awake laparoscopy. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg 10:545 (author reply 545–546)
Metadata
Title
Warmed and humidified carbon dioxide for abdominal laparoscopic surgery: meta-analysis of the current literature
Authors
David Balayssac
Bruno Pereira
Jean-Etienne Bazin
Bertrand Le Roy
Denis Pezet
Johan Gagnière
Publication date
01-01-2017
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 1/2017
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-016-4866-1

Other articles of this Issue 1/2017

Surgical Endoscopy 1/2017 Go to the issue