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Surgical Endoscopy

Published in:

01-03-2016

Novel flower-type covered metal stent to prevent cholecystitis: experimental study in a pig model

Authors: Young Sik Woo, Kwang Hyuck Lee, Jong Kyun Lee, Dong Hyo Noh, Joo Kyung Park, Kyu Taek Lee, Kee-Taek Jang

Published in: Surgical Endoscopy | Issue 3/2016

Abstract

Background

Covered self-expandable metal stent (CSEMS) has the risk of obstruction of the cystic duct, and the main and branch pancreatic ducts due to strong radial force and covering material, which results in cholecystitis and pancreatitis. A flower-type covered self-expandable metal stent (F-CSEMS) having a five-petal-shaped design with side grooves was constructed to prevent the obstruction of the cystic duct orifice. This study investigated the value of the F-CSEMS in protection for cholecystitis in a pig model.

Methods

Fourteen pigs randomly underwent endoscopic placement of either F-CSEMS or conventional CSEMS (C-CSEMS). The stent was placed across the cystic duct orifice to impede bile drainage from the gallbladder. Drainage was checked at 24, 48, 120 and 168 h after implantation. Blood was collected at baseline, on days 2 and 7 following implantation. The animals were killed for histologic evaluation on day 7.

Results

All stents were successfully inserted into bile duct without any procedure-related complications. At 48 h, the rate of contrast drainage from the gallbladder was higher in the F-CSEMS group than the C-CSEMS group without significant difference (71.4 vs. 28.6 % p = 0.28). C-CSEMS was associated with higher levels of C-reactive protein (35.2 vs. 20.5 µg/dl, p = 0.03) and histologic inflammatory scores of gallbladder (score 4 vs. 2; p = 0.03).

Conclusion

The F-CSEMS appears safe and helpful to prevent cholecystitis without disturbance of bile flow in a pig model.

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Title: Novel flower-type covered metal stent to prevent cholecystitis: experimental study in a pig model
Authors: Young Sik Woo
Kwang Hyuck Lee
Jong Kyun Lee
Dong Hyo Noh
Joo Kyung Park
Kyu Taek Lee
Kee-Taek Jang
Publication date: 01-03-2016
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 3/2016
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-015-4317-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Novel flower-type covered metal stent to prevent cholecystitis: experimental study in a pig model

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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