Skip to main content
Top
Published in: Surgical Endoscopy 4/2014

01-04-2014

8 Years’ experience with robotic thymectomy for thymomas

Authors: Marlies Keijzers, Anne-Marie C. Dingemans, Hans Blaauwgeers, Robert Jan van Suylen, Monique Hochstenbag, Leen van Garsse, Ryan Accord, Mark de Baets, Jos Maessen

Published in: Surgical Endoscopy | Issue 4/2014

Login to get access

Abstract

Background

The accuracy of a three-dimensional robotic-assisted videothoracoscopic approach may favor a radical resection of thymomas. The aim of this study was to demonstrate the feasibility of the robotic approach by reporting 8 years experience in a single referral center of surgical treatment of thymomas.

Methods

We retrospectively analyzed all consecutive patients who underwent a thymectomy from April 2004 to April 2012. We analyzed the procedure time, morbidity, mortality, conversions, hospitalization, freedom from recurrence, time to progression, and overall survival.

Results

From 2004 until 2012, a total of 138 robotic procedures for mediastinal tumors were performed in our center, of which 37 patients with a mean age of 57.3 years underwent a thymectomy for a thymoma. Histological analysis revealed four type A thymomas (10.8 %), seven type AB thymomas (18.9 %), seven type B1 thymomas (18.9 %), fourteen type B2 thymomas (37.8 %), four type B3 thymomas (10.8 %), and one thymus carcinoma (2.7 %). The Masaoka–Koga stages were as follows: stage I in twenty patients (54 %), stage IIA in five patients (13.5 %), stage IIB in eight patients (21.6 %), stage III in three patients (8.1 %), and stage IVa in one patient (2.7 %). The mean overall procedure time was 149 min (range 88–353). No surgical mortality was reported, and there were no peri-operative complications. No conversions were needed for surgical complications. In three cases, a conversion to sternotomy was preferred by the surgeon because tumor invasion in greater vessels was suspected. Two patients (5.4 %) suffered from a myasthenic crisis postoperatively and required prolonged mechanical ventilation. One patient (2.7 %) underwent a procedure for a thoracic herniation 6 months following thymectomy. The median hospitalization was 3 days. The follow-up analysis showed an overall survival of 100 % and tumor recurrence in one patient (2.7 %).

Conclusions

Robotic thymectomies are safe in patients with early-stage thymomas. Robotic surgery may also be feasible for some selected advanced thymomas.
Literature
1.
go back to reference Dmitriev EG, Sigal EI (1996) Thoracoscopic surgery in the management of mediastinal masses. Indications, complications, limitations. Surg Endosc 10(7):718–720PubMedCrossRef Dmitriev EG, Sigal EI (1996) Thoracoscopic surgery in the management of mediastinal masses. Indications, complications, limitations. Surg Endosc 10(7):718–720PubMedCrossRef
2.
go back to reference Rückert JC, Ismail M, Swierzy M, Sobel H, Rogalla P, Meisel A et al (2008) Thoracoscopic thymectomy with the da Vinci robotic system for myasthenia gravis. Ann N Y Acad Sci 1132:329–335PubMedCrossRef Rückert JC, Ismail M, Swierzy M, Sobel H, Rogalla P, Meisel A et al (2008) Thoracoscopic thymectomy with the da Vinci robotic system for myasthenia gravis. Ann N Y Acad Sci 1132:329–335PubMedCrossRef
3.
go back to reference Ishikawa N, Sun YS, Nifong LW, Oda M, Watanabe G, Chitwood WR Jr (2009) Thoracoscopic robot-assisted extended thymectomy in the human cadaver. Surg Endosc 23(2):459–461PubMedCrossRef Ishikawa N, Sun YS, Nifong LW, Oda M, Watanabe G, Chitwood WR Jr (2009) Thoracoscopic robot-assisted extended thymectomy in the human cadaver. Surg Endosc 23(2):459–461PubMedCrossRef
4.
go back to reference Freeman RK, Ascioti AJ, Van Woerkom JM, Vyverberg A, Robison RJ (2011) Long-term follow-up after robotic thymectomy for nonthymomatous myasthenia gravis. Ann Thorac Surg 92(3):1018–1022 discussion 22–23PubMedCrossRef Freeman RK, Ascioti AJ, Van Woerkom JM, Vyverberg A, Robison RJ (2011) Long-term follow-up after robotic thymectomy for nonthymomatous myasthenia gravis. Ann Thorac Surg 92(3):1018–1022 discussion 22–23PubMedCrossRef
5.
go back to reference Mussi A, Fanucchi O, Davini F, Lucchi M, Picchi A, Ambrogi MC et al (2012) Robotic extended thymectomy for early-stage thymomas. Eur J Cardiothorac Surg 41(4):e43–e46 discussion e7PubMedCrossRef Mussi A, Fanucchi O, Davini F, Lucchi M, Picchi A, Ambrogi MC et al (2012) Robotic extended thymectomy for early-stage thymomas. Eur J Cardiothorac Surg 41(4):e43–e46 discussion e7PubMedCrossRef
6.
go back to reference Marulli G, Rea F, Melfi F, Schmid TA, Ismail M, Fanucchi O et al (2012) Robot-aided thoracoscopic thymectomy for early-stage thymoma: a multicenter European study. J Thorac Cardiovasc Surg 144(5):1125–1130PubMedCrossRef Marulli G, Rea F, Melfi F, Schmid TA, Ismail M, Fanucchi O et al (2012) Robot-aided thoracoscopic thymectomy for early-stage thymoma: a multicenter European study. J Thorac Cardiovasc Surg 144(5):1125–1130PubMedCrossRef
7.
go back to reference Huang J, Detterbeck FC, Wang Z, Loehrer PJ Sr (2010) Standard outcome measures for thymic malignancies. J Thorac Oncol 5(12):2017–2023PubMedCrossRef Huang J, Detterbeck FC, Wang Z, Loehrer PJ Sr (2010) Standard outcome measures for thymic malignancies. J Thorac Oncol 5(12):2017–2023PubMedCrossRef
9.
go back to reference Jaretzki A 3rd, Barohn RJ, Ernstoff RM, Kaminski HJ, Keesey JC, Penn AS et al (2000) Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Ann Thorac Surg 70(1):327–334PubMedCrossRef Jaretzki A 3rd, Barohn RJ, Ernstoff RM, Kaminski HJ, Keesey JC, Penn AS et al (2000) Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Ann Thorac Surg 70(1):327–334PubMedCrossRef
10.
go back to reference Toker A, Sonett J, Zielinski M, Rea F, Tomulescu V, Detterbeck FC (2011) Standard terms, definitions, and policies for minimally invasive resection of thymoma. J Thorac Oncol 6(7 Suppl 3):S1739–S1742PubMedCrossRef Toker A, Sonett J, Zielinski M, Rea F, Tomulescu V, Detterbeck FC (2011) Standard terms, definitions, and policies for minimally invasive resection of thymoma. J Thorac Oncol 6(7 Suppl 3):S1739–S1742PubMedCrossRef
11.
go back to reference Dylewski MR, Ohaeto AC, Pereira JF (2011) Pulmonary resection using a total endoscopic robotic video-assisted approach. Semin Thorac Cardiovasc Surg 23(1):36–42PubMedCrossRef Dylewski MR, Ohaeto AC, Pereira JF (2011) Pulmonary resection using a total endoscopic robotic video-assisted approach. Semin Thorac Cardiovasc Surg 23(1):36–42PubMedCrossRef
12.
go back to reference Nakamura H, Taniguchi Y, Fujioka S, Miwa K, Haruki T, Takagi Y et al (2012) First experience of robotic extended thymectomy in Japan for myasthenia gravis with thymoma. Gen Thorac Cardiovasc Surg 60(3):183–187PubMedCrossRef Nakamura H, Taniguchi Y, Fujioka S, Miwa K, Haruki T, Takagi Y et al (2012) First experience of robotic extended thymectomy in Japan for myasthenia gravis with thymoma. Gen Thorac Cardiovasc Surg 60(3):183–187PubMedCrossRef
13.
go back to reference Roviaro G, Varoli F, Nucca O, Vergani C, Maciocco M (2000) Videothoracoscopic approach to primary mediastinal pathology. Chest 117(4):1179–1183PubMedCrossRef Roviaro G, Varoli F, Nucca O, Vergani C, Maciocco M (2000) Videothoracoscopic approach to primary mediastinal pathology. Chest 117(4):1179–1183PubMedCrossRef
14.
go back to reference Pennathur A, Qureshi I, Schuchert MJ, Dhupar R, Ferson PF, Gooding WE et al (2011) Comparison of surgical techniques for early-stage thymoma: feasibility of minimally invasive thymectomy and comparison with open resection. J Thorac Cardiovasc Surg 141(3):694–701PubMedCrossRef Pennathur A, Qureshi I, Schuchert MJ, Dhupar R, Ferson PF, Gooding WE et al (2011) Comparison of surgical techniques for early-stage thymoma: feasibility of minimally invasive thymectomy and comparison with open resection. J Thorac Cardiovasc Surg 141(3):694–701PubMedCrossRef
15.
go back to reference Cheng YJ, Kao EL, Chou SH (2005) Videothoracoscopic resection of stage II thymoma: prospective comparison of the results between thoracoscopy and open methods. Chest 128(4):3010–3012PubMedCrossRef Cheng YJ, Kao EL, Chou SH (2005) Videothoracoscopic resection of stage II thymoma: prospective comparison of the results between thoracoscopy and open methods. Chest 128(4):3010–3012PubMedCrossRef
16.
go back to reference Ruckert JC, Swierzy M, Ismail M (2011) Comparison of robotic and nonrobotic thoracoscopic thymectomy: a cohort study. J Thorac Cardiovasc Surg 141(3):673–677PubMedCrossRef Ruckert JC, Swierzy M, Ismail M (2011) Comparison of robotic and nonrobotic thoracoscopic thymectomy: a cohort study. J Thorac Cardiovasc Surg 141(3):673–677PubMedCrossRef
17.
18.
go back to reference Tormoehlen LM, Pascuzzi RM (2008) Thymoma, myasthenia gravis, and other paraneoplastic syndromes. Hematol Oncol Clin North Am 22(3):509–526PubMedCrossRef Tormoehlen LM, Pascuzzi RM (2008) Thymoma, myasthenia gravis, and other paraneoplastic syndromes. Hematol Oncol Clin North Am 22(3):509–526PubMedCrossRef
19.
go back to reference Lucchi M, Ricciardi R, Melfi F, Duranti L, Basolo F, Palmiero G et al (2009) Association of thymoma and myasthenia gravis: oncological and neurological results of the surgical treatment. Eur J Cardiothorac Surg 35(5):812–816 discussion 6PubMedCrossRef Lucchi M, Ricciardi R, Melfi F, Duranti L, Basolo F, Palmiero G et al (2009) Association of thymoma and myasthenia gravis: oncological and neurological results of the surgical treatment. Eur J Cardiothorac Surg 35(5):812–816 discussion 6PubMedCrossRef
20.
go back to reference Lopez-Cano M, Ponseti-Bosch JM, Espin-Basany E, Sanchez-Garcia JL, Armengol-Carrasco M (2003) Clinical and pathologic predictors of outcome in thymoma-associated myasthenia gravis. Ann Thorac Surg 76(5):1643–1649 discussion 9PubMedCrossRef Lopez-Cano M, Ponseti-Bosch JM, Espin-Basany E, Sanchez-Garcia JL, Armengol-Carrasco M (2003) Clinical and pathologic predictors of outcome in thymoma-associated myasthenia gravis. Ann Thorac Surg 76(5):1643–1649 discussion 9PubMedCrossRef
21.
go back to reference Vachlas K, Zisis C, Rontogianni D, Tavernarakis A, Psevdi A, Bellenis I (2012) Thymoma and myasthenia gravis: clinical aspects and prognosis. Asian Cardiovasc Thorac Ann 20(1):48–52PubMedCrossRef Vachlas K, Zisis C, Rontogianni D, Tavernarakis A, Psevdi A, Bellenis I (2012) Thymoma and myasthenia gravis: clinical aspects and prognosis. Asian Cardiovasc Thorac Ann 20(1):48–52PubMedCrossRef
22.
go back to reference Bhamidipati CM, Iyalla KI, Seymour KA, Lutz CJ (2012) Lung hernia following robotic-assisted mitral valve repair. J Cardiac Surg 27(4):460–463CrossRef Bhamidipati CM, Iyalla KI, Seymour KA, Lutz CJ (2012) Lung hernia following robotic-assisted mitral valve repair. J Cardiac Surg 27(4):460–463CrossRef
23.
go back to reference Athanassiadi K, Bagaev E, Simon A, Haverich A (2008) Lung herniation: a rare complication in minimally invasive cardiothoracic surgery. Eur J Cardiothorac Surg 33(5):774–776PubMedCrossRef Athanassiadi K, Bagaev E, Simon A, Haverich A (2008) Lung herniation: a rare complication in minimally invasive cardiothoracic surgery. Eur J Cardiothorac Surg 33(5):774–776PubMedCrossRef
Metadata
Title
8 Years’ experience with robotic thymectomy for thymomas
Authors
Marlies Keijzers
Anne-Marie C. Dingemans
Hans Blaauwgeers
Robert Jan van Suylen
Monique Hochstenbag
Leen van Garsse
Ryan Accord
Mark de Baets
Jos Maessen
Publication date
01-04-2014
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 4/2014
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-013-3309-5

Other articles of this Issue 4/2014

Surgical Endoscopy 4/2014 Go to the issue