Skip to main content
Top
Published in: Surgical Endoscopy 12/2008

01-12-2008

Conversion of laparoscopic colon resection does not affect survival in colon cancer

Authors: Jan Franko, Steven A. Fassler, Masoud Rezvani, Brendan G. O’Connell, Steven G. Harper, Joseph H. Nejman, D. Mark Zebley

Published in: Surgical Endoscopy | Issue 12/2008

Login to get access

Abstract

Background

Laparoscopic and open resections of colon cancer are considered oncologically equivalent treatment methods. Conversion of laparoscopic procedures, however, was associated with decreased survival in colon cancer patients in the only prior study examining this question. We conducted this study to evaluate the effect of conversion on survival.

Methods

A series of consecutive patients treated with laparoscopic resection of colorectal cancer (n = 174) in the period 1998–2003 was evaluated retrospectively. Median follow-up was 51 months with a minimum of 3 years.

Results

There was no statistically significant difference in all-cause mortality between laparoscopically completed and converted groups (22/143, 15.4% versus 8/31, 25.8%; OR 1.9, p = 0.164). Kaplan–Meier survival analysis did not show any survival difference between the two groups (p = 0.266).

Conclusions

The results of our study suggest there is no survival difference in patients requiring conversion of laparoscopic resection indicated for colorectal cancer. Further examination of this question is warranted to determine whether laparoscopic resection of colorectal cancer should be offered to all patients, including those at high risk for conversion.
Literature
1.
go back to reference Liang JT, Huang KC, Lai HS, Lee PH, Jeng YM (2007) Oncologic results of laparoscopic versus conventional open surgery for stage II or III left-sided colon cancers: a randomized controlled trial. Ann Surg Oncol 14:109–117PubMedCrossRef Liang JT, Huang KC, Lai HS, Lee PH, Jeng YM (2007) Oncologic results of laparoscopic versus conventional open surgery for stage II or III left-sided colon cancers: a randomized controlled trial. Ann Surg Oncol 14:109–117PubMedCrossRef
2.
go back to reference Leung KL, Kwok SP, Lam SC, Lee JF, Yiu RY, Ng SS, Lai PB, Lau WY (2004) Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Lancet 363:1187–1192PubMedCrossRef Leung KL, Kwok SP, Lam SC, Lee JF, Yiu RY, Ng SS, Lai PB, Lau WY (2004) Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Lancet 363:1187–1192PubMedCrossRef
3.
go back to reference Lacy AM, Garcia-Valdecasas JC, Delgado S, Castells A, Taura P, Pique JM, Visa J (2002) Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet 359:2224–2229PubMedCrossRef Lacy AM, Garcia-Valdecasas JC, Delgado S, Castells A, Taura P, Pique JM, Visa J (2002) Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet 359:2224–2229PubMedCrossRef
4.
go back to reference Clinical Outcomes of Surgical Therapy Study Group (2004) A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 350:2050–2059 Clinical Outcomes of Surgical Therapy Study Group (2004) A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 350:2050–2059
5.
go back to reference Lujan HJ, Plasencia G, Jacobs M, Viamonte M III, Hartmann RF (2002) Long-term survival after laparoscopic colon resection for cancer: complete five-year follow-up. Dis Colon Rectum 45:491–501PubMedCrossRef Lujan HJ, Plasencia G, Jacobs M, Viamonte M III, Hartmann RF (2002) Long-term survival after laparoscopic colon resection for cancer: complete five-year follow-up. Dis Colon Rectum 45:491–501PubMedCrossRef
6.
go back to reference Patankar SK, Larach SW, Ferrara A, Williamson PR, Gallagher JT, DeJesus S, Narayanan S (2003) Prospective comparison of laparoscopic vs. open resections for colorectal adenocarcinoma over a ten-year period. Dis Colon Rectum 46:601–611PubMedCrossRef Patankar SK, Larach SW, Ferrara A, Williamson PR, Gallagher JT, DeJesus S, Narayanan S (2003) Prospective comparison of laparoscopic vs. open resections for colorectal adenocarcinoma over a ten-year period. Dis Colon Rectum 46:601–611PubMedCrossRef
7.
go back to reference Capussotti L, Massucco P, Muratore A, Amisano M, Bima C, Zorzi D (2004) Laparoscopy as a prognostic factor in curative resection for node positive colorectal cancer: results for a single-institution nonrandomized prospective trial. Surg Endosc 18:1130–1135PubMedCrossRef Capussotti L, Massucco P, Muratore A, Amisano M, Bima C, Zorzi D (2004) Laparoscopy as a prognostic factor in curative resection for node positive colorectal cancer: results for a single-institution nonrandomized prospective trial. Surg Endosc 18:1130–1135PubMedCrossRef
8.
go back to reference Moloo H, Mamazza J, Poulin EC, Burpee SE, Bendavid Y, Klein L, Gregoire R, Schlachta CM (2004) Laparoscopic resections for colorectal cancer: does conversion survival? Surg Endosc 18:732–735PubMedCrossRef Moloo H, Mamazza J, Poulin EC, Burpee SE, Bendavid Y, Klein L, Gregoire R, Schlachta CM (2004) Laparoscopic resections for colorectal cancer: does conversion survival? Surg Endosc 18:732–735PubMedCrossRef
9.
go back to reference Franko J, O’Connell BG, Mehall JR, Harper SG, Nejman JH, Zebley DM, Fassler SA (2006) The influence of prior abdominal operations on conversion and complication rates in laparoscopic colorectal surgery. JSLS 10:169–175PubMed Franko J, O’Connell BG, Mehall JR, Harper SG, Nejman JH, Zebley DM, Fassler SA (2006) The influence of prior abdominal operations on conversion and complication rates in laparoscopic colorectal surgery. JSLS 10:169–175PubMed
10.
go back to reference Liefers GJ, Cleton-Jansen AM, van de Velde CJ, Hermans J, van Krieken JH, Cornelisse CJ, Tollenaar RA (1998) Micrometastases and survival in stage II colorectal cancer. N Engl J Med 339:223–228PubMedCrossRef Liefers GJ, Cleton-Jansen AM, van de Velde CJ, Hermans J, van Krieken JH, Cornelisse CJ, Tollenaar RA (1998) Micrometastases and survival in stage II colorectal cancer. N Engl J Med 339:223–228PubMedCrossRef
11.
go back to reference Greene FL, Stewart AK, Norton HJ (2002) A new TNM staging strategy for node-positive (stage III) colon cancer: an analysis of 50,042 patients. Ann Surg 236:416–421; discussion 421PubMedCrossRef Greene FL, Stewart AK, Norton HJ (2002) A new TNM staging strategy for node-positive (stage III) colon cancer: an analysis of 50,042 patients. Ann Surg 236:416–421; discussion 421PubMedCrossRef
12.
go back to reference Greene FL (2002) The American Joint Committee on Cancer: updating the strategies in cancer staging. Bull Am Coll Surg 87:13–15PubMed Greene FL (2002) The American Joint Committee on Cancer: updating the strategies in cancer staging. Bull Am Coll Surg 87:13–15PubMed
13.
go back to reference Prandi M, Lionetto R, Bini A, Francioni G, Accarpio G, Anfossi A, Ballario E, Becchi G, Bonilauri S, Carobbi A, Cavaliere P, Garcea D, Giuliani L, Morziani E, Mosca F, Mussa A, Pasqualini M, Poddie D, Tonetti F, Zardo L, Rosso R (2002) Prognostic evaluation of stage B colon cancer patients is improved by an adequate lymphadenectomy: results of a secondary analysis of a large scale adjuvant trial. Ann Surg 235:458–463PubMedCrossRef Prandi M, Lionetto R, Bini A, Francioni G, Accarpio G, Anfossi A, Ballario E, Becchi G, Bonilauri S, Carobbi A, Cavaliere P, Garcea D, Giuliani L, Morziani E, Mosca F, Mussa A, Pasqualini M, Poddie D, Tonetti F, Zardo L, Rosso R (2002) Prognostic evaluation of stage B colon cancer patients is improved by an adequate lymphadenectomy: results of a secondary analysis of a large scale adjuvant trial. Ann Surg 235:458–463PubMedCrossRef
14.
go back to reference Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Pahlman L, Cuesta MA, Msika S, Morino M, Lacy AM (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6:477–484PubMedCrossRef Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Pahlman L, Cuesta MA, Msika S, Morino M, Lacy AM (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6:477–484PubMedCrossRef
15.
go back to reference Gitzelmann CA, Mendoza-Sagaon M, Talamini MA, Ahmad SA, Pegoli W Jr, Paidas CN (2000) Cell-mediated immune response is better preserved by laparoscopy than laparotomy. Surgery 127:65–71PubMedCrossRef Gitzelmann CA, Mendoza-Sagaon M, Talamini MA, Ahmad SA, Pegoli W Jr, Paidas CN (2000) Cell-mediated immune response is better preserved by laparoscopy than laparotomy. Surgery 127:65–71PubMedCrossRef
16.
go back to reference Lee SW, Gleason N, Blanco I, Asi ZK, Whelan RL (2002) Higher colon cancer tumor proliferative index and lower tumor cell death rate in mice undergoing laparotomy versus insufflation. Surg Endosc 16:36–39PubMedCrossRef Lee SW, Gleason N, Blanco I, Asi ZK, Whelan RL (2002) Higher colon cancer tumor proliferative index and lower tumor cell death rate in mice undergoing laparotomy versus insufflation. Surg Endosc 16:36–39PubMedCrossRef
17.
go back to reference Gutt CN, Gessmann T, Schemmer P, Mehrabi A, Schmandra T, Kim ZG (2003) The impact of carbon dioxide and helium insufflation on experimental liver metastases, macrophages, and cell adhesion molecules. Surg Endosc 17:1628–1631PubMedCrossRef Gutt CN, Gessmann T, Schemmer P, Mehrabi A, Schmandra T, Kim ZG (2003) The impact of carbon dioxide and helium insufflation on experimental liver metastases, macrophages, and cell adhesion molecules. Surg Endosc 17:1628–1631PubMedCrossRef
18.
go back to reference Noel JK, Fahrbach K, Estok R, Cella C, Frame D, Linz H, Cima RR, Dozois EJ, Senagore AJ (2007) Minimally invasive colorectal resection outcomes: short-term comparison with open procedures. J Am Coll Surg 204:291–307PubMedCrossRef Noel JK, Fahrbach K, Estok R, Cella C, Frame D, Linz H, Cima RR, Dozois EJ, Senagore AJ (2007) Minimally invasive colorectal resection outcomes: short-term comparison with open procedures. J Am Coll Surg 204:291–307PubMedCrossRef
19.
go back to reference Belizon A, Sardinha CT, Sher ME (2006) Converted laparoscopic colectomy: what are the consequences? Surg Endosc 20:947–951PubMedCrossRef Belizon A, Sardinha CT, Sher ME (2006) Converted laparoscopic colectomy: what are the consequences? Surg Endosc 20:947–951PubMedCrossRef
20.
go back to reference Gonzalez R, Smith CD, Mason E, Duncan T, Wilson R, Miller J, Ramshaw BJ (2006) Consequences of conversion in laparoscopic colorectal surgery. Dis Colon Rectum 49:197–204PubMedCrossRef Gonzalez R, Smith CD, Mason E, Duncan T, Wilson R, Miller J, Ramshaw BJ (2006) Consequences of conversion in laparoscopic colorectal surgery. Dis Colon Rectum 49:197–204PubMedCrossRef
21.
go back to reference Casillas S, Delaney CP, Senagore AJ, Brady K, Fazio VW (2004) Does conversion of a laparoscopic colectomy adversely affect patient outcome? Dis Colon Rectum 47:1680–1685PubMedCrossRef Casillas S, Delaney CP, Senagore AJ, Brady K, Fazio VW (2004) Does conversion of a laparoscopic colectomy adversely affect patient outcome? Dis Colon Rectum 47:1680–1685PubMedCrossRef
Metadata
Title
Conversion of laparoscopic colon resection does not affect survival in colon cancer
Authors
Jan Franko
Steven A. Fassler
Masoud Rezvani
Brendan G. O’Connell
Steven G. Harper
Joseph H. Nejman
D. Mark Zebley
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Surgical Endoscopy / Issue 12/2008
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-008-9812-4

Other articles of this Issue 12/2008

Surgical Endoscopy 12/2008 Go to the issue