Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Surgical Endoscopy
Published in: Surgical Endoscopy 9/2006

01-09-2006

Proton pump inhibitors reduce gallbladder function

Authors: M. A. Cahan, L. Balduf, K. Colton, B. Palacioz, W. McCartney, T. M. Farrell

Published in: Surgical Endoscopy | Issue 9/2006

Login to get access

Abstract

Background

In the authors’ previous study of gallbladder function before and after fundoplication, 58% of the patients demonstrated preoperative gallbladder motor dysfunction, and 86% of those retested after operation and cessation of proton pump inhibitors (PPIs) normalized. Because no study has directly assessed the impact of antisecretory agents on gallbladder function, this study measured gallbladder ejection fraction (GBEF) in healthy volunteers before and after initiation of PPIs.

Methods

A total of 19 subjects completed the study, which included baseline determination of GBEF by cholecystokinin-stimulated hepatobiliary acid scan, 30 days of antisecretory therapy with omeprazole (40 mg daily), and repeat GBEF on day 30. Subjects were surveyed regarding compliance and symptoms.

Results

For 15 of 19 subjects, PPI therapy was associated with reduced gallbladder motility. Evolution of symptoms consistent with a biliary etiology was reported by 26.7% of these subjects.

Conclusions

Short-term PPI therapy reduces gallbladder motility in healthy volunteers. Chronic PPI therapy may pose a risk for long-term gallbladder dysfunction and biliary complications.
Literature
1.
Avidan B, Sonnenberg A, Schnell TG, Sontag SJ (2001) No association between gallstones and gastroesophageal reflux disease. Am J Gastroenterol 96: 2858–2862PubMedCrossRef
2.
Bardhan KD (1999) Pantoprazole: a new proton pump inhibitor in the management of upper gastrointestinal disease. Drugs Today (Barc) 35: 773–808
3.
Bucceri AM, Calogero AE, Brogna A (2002) Gallbladder and gastric emptying: relationship to cholecystokininemia in diabetics. Eur J Intern Med 13: 123–128PubMedCrossRef
4.
Cadiot G, Vissuzaine C, Pospai D, Ruszniewski P, Potet F, Mignon M (1995) Effect of prolonged treatment with proton pump inhibitors on serum gastrin levels and the fundus mucosa: preliminary results. Gastroenterol Clin Biol 19: 811–817PubMed
5.
Capron JP, Payenneville H, Dumont M, Dupas JL, Lorriaux A (1978) Evidence for an association between cholelithiasis and hiatus hernia. Lancet 2: 329–331PubMed
6.
Cattey RP, Wilson SD (1989) Cholelithiasis follows total gastrectomy in Zollinger-Ellison syndrome. Surgery 106: 1070–1073PubMed
7.
Chowdhury JR, Berkowitz JM, Praissman M, Fara JW (1975) Interaction between octapeptide-cholecystokinin, gastrin, and secretin on cat gallbladder in vitro. Am J Physiol; 229: 1311–1315PubMed
8.
Chowdhury JR, Berkowitz JM, Praissman M, Fara JW (1976) Effect of sulfated and nonsulfated gastrin and octapeptide-cholecystokinin on cat gall bladder in vitro. Experientia 32: 1173–1175PubMedCrossRef
9.
DiBaise JK, Oleynikov D (2003) Does gallbladder ejection fraction predict outcome after cholecystectomy for suspected chronic acalculous gallbladder dysfunction? A systematic review. Am J Gastroenterol 98: 2605–2611PubMedCrossRef
10.
Festen HP, Thijs JC, Lamers CB, Jansen JM, Pals G, Frants RR, Defize J, Meuwissen SG (1984) Effect of oral omeprazole on serum gastrin and serum pepsinogen I levels. Gastroenterology 87: 1030–1034PubMed
11.
Gallup Organization (1988) A Gallup Organization National Survey: Heartburn Across America. Gallup Organization, Princeton, NJ
12.
Grider JR, Makhlouf GM (1990) Distinct receptors for cholecystokinin and gastrin on muscle cells of stomach and gallbladder. Am J Physiol 259: G184–G190PubMed
13.
Koop H, Klein M, Arnold R (1990) Serum gastrin levels during long-term omeprazole treatment. Aliment Pharm Ther 4: 131–138CrossRef
14.
Krishnamurthy GT, Krishnamurthy S, Brown PH (2004) Constancy and variability of gallbladder ejection fraction: impact on diagnosis and therapy. J Nucl Med 45: 1872–1877PubMed
15.
Krishnamurthy S, Krishnamurthy GT (1997) Biliary dyskinesia: role of the sphincter of Oddi, gallbladder, and cholecystokinin. J Nucl Med 38: 1824–1830PubMed
16.
Manifold DK, Anggiansah A, Owen WJ (2000) Effect of cholecystectomy on gastroesophageal and duodenogastric reflux. Am J Gastroenterol 95: 2746–2750PubMed
17.
Morton JM, Bowers SP, Lucktong TA, Mattar S, Bradshaw WA, Behrns KE, Koruda MJ, Herbst CA, McCartney W, Halkar RK, Smith CD, Farrell TM (2002) Gallbladder function before and after fundoplication. J Gastrointest Surg 6: 806–810PubMedCrossRef
18.
Ohara T, Morishita T, Suzuki H, Masaoka T, Ishii H (2004) Usefulness of proton pump inhibitor (PPI) maintenance therapy for patients with Helicobacter pylori-negative recurrent peptic ulcer after eradication therapy for H. pylori: pathophysiological characteristics of H. pylori-negative recurrent ulcer scars and beyond acid suppression by PPI. Hepatogastroenterology 51: 338–342PubMed
19.
Portincasa P, Di Ciaula A, Palmieri V, Velardi A, VanBerge-Henegouwen GP, Palasciano G (1997) Impaired gallbladder and gastric motility and pathological gastro-oesophageal reflux in gallstone patients. Eur J Clin Invest 27: 653–661PubMedCrossRef
20.
Rasmussen L, Oster-Jorgensen E, Qvist N, Hovendal CP, Kraglund K, Olsen O, Schaffalitzky de Muckadell OB, Rehfeld J, Pedersen SA (1992) The effects of omeprazole on interdigestive motility and early postprandial levels of gastrin and secretin. Scan J Gastroenterol 27: 119–123CrossRef
21.
Rasmussen L, Qvist N, Oster-Jorgensen E, Rehfeld JF, Holst JJ, Pedersen SA (1997) A double-blind placebo-controlled study of the effects of omeprazole on gut hormone secretion and gastric emptying rate. Scand J Gastroenterol 32: 900–905PubMed
22.
Ryan J, Cohen S (1976) Gallbladder pressure–volume response to gastrointestinal hormones. Am J Physiol 230: 1461–1465PubMed
23.
Schjoldager BT (1994) Role of CCK in gallbladder function. Ann NY Acad Sci 713: 207–218PubMed
24.
Toouli J, Hogan WJ, Geenen JE, Dodds WJ, Arndorfer RC (1982) Action of cholecystokinin octapeptide on sphincter of Oddi basal pressure and phasic wave activity in humans. Surgery 92: 497–503PubMed
25.
Vaczek D (2003) Top 200 drugs of 2002. Pharm Times, April p 20
26.
Valenzuela JE, Walsh JH, Isenberg JI (1976) Effect of gastrin on pancreatic enzyme secretion and gallbladder emptying in man. Gastroenterology 71: 409–411PubMed
27.
Watson S, Arkinstall S (1994) Cholecystokinin (CCK) and gastrin. In: Watson S, Arkinstall S (eds) The G Protein-Linked Receptor Factsbook. Academic Press, London pp 89–95
Metadata
Title
Proton pump inhibitors reduce gallbladder function
Authors
M. A. Cahan
L. Balduf
K. Colton
B. Palacioz
W. McCartney
T. M. Farrell
Publication date
01-09-2006
Publisher
Springer-Verlag
Published in
Surgical Endoscopy / Issue 9/2006
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-005-0247-x

Other articles of this Issue 9/2006

Surgical Endoscopy 9/2006 Go to the issue

OriginalPaper

Mirizzi syndrome: laparoscopic management by subtotal cholecystectomy

OriginalPaper

Laparoscopic rectal prolapse surgery combined with short hospital stay is safe in elderly and debilitated patients

Review article

Intrathoracoscopic localization techniques

OriginalPaper

Endoscopic stenting for selected cases of biliary fistula after hepatic hydatid surgery

OriginalPaper

The role of telementoring and telerobotic assistance in the provision of laparoscopic colorectal surgery in rural areas

Technique

Laparoscopically assisted total gastrectomy with jejunal pouch interposition