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Surgical Endoscopy
Published in: Surgical Endoscopy 12/2004

01-12-2004 | Original article

Sentinel lymph node mapping in colon cancer

Authors: J.-J. Tuech, P. Pessaux, N. Regenet, R. Bergamaschi, A. Colson

Published in: Surgical Endoscopy | Issue 12/2004

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Abstract

Background

By systematically reviewing the literature on sentinel lymph node mapping of colon cancers, this study aimed to evaluate this technique as it applies to colon cancers.

Methods

Human studies on lymphatic mapping for colon cancers were reviewed. Multiple publications of the same studies, abstracts, and case reports were excluded. Current Contents, MEDLINE, EMBASE, and Cochrane Library databases were investigated.

Results

Lymphatic mapping appears to be readily applicable to colon cancers, identifying lymph nodes most likely to harbor metastases. Identification of sentinel lymph nodes varied from 58% to 100% and carried a false-negative rate of approximately 10% in larger studies, but potentially rose 4% to 25% among patients representing a range from node-negative to node-positive (micrometastases) conditions. The prognostic implication of these micrometastases requires further evaluation. Lymphatic mapping in 6% to 29% of cases identified aberrant lymphatic drainage that altered the extent of the lymphadenectomy.

Conclusions

Further follow-up evaluation to assess the prognostic significance of micrometastases for colon cancers is required before the staging benefits of sentinel node mapping can have therapeutic implications. Lymphatic mapping offers the possibility of improving staging by identifying patients with early disseminated disease who should be considered for adjuvant treatment or included in trials of adjuvant treatment to speed up the breakthrough of more effective adjuvant regimens. Large studies are needed to determine whether the sentinel node concept is as valid for colon cancers as studies so far have shown it is for malignant melanoma and breast cancer.
Literature
1.
Abati, A, Liotta, LA 1996Looking forward in diagnostic pathology: the molecular superhighwayCancer7813PubMedCrossRef
2.
Adell, G, Boeryd, B, Franlund, B, Sjodahl, R, Hakansson, L 1996Occurrence and prognostic importance of micrometastases in regional lymph nodes in Dukes’ B colorectal carcinoma: an immunohistochemical studyEur J Surg162637642PubMed
3.
Andreola, S, Leo, E, Belli, F, Gallino, G, Sirizzotti, G, Sampietro, G 2001Adenocarcinoma of the lower third of the rectum: metastases in lymph nodes smaller than 5 mm and occult micrometastases: preliminary results on early tumor recurrenceAnn Surg Oncol8413417PubMedCrossRef
4.
5.
Bembenek, A, Bayraktar, S, Gretschel, S, Ulmer, C, Schulze, T, Markwardt, J, Schneider, U, Hunerbein, M, Schlag, PM 2002Sentinel lymphonodectomy in gastrointestinal cancer: where are we now?Onkologie25334340PubMed
6.
Bendavid, Y, Latulippe, JF, Younan, RJ, Leclerc, YE, Dube, S, Heyen, F, Morin, M, Girard, R, Bastien, E, Ferreira, J, Cerino, M, Dube, P 2002Phase I study on sentinel lymph node mapping in colon cancer: a preliminary reportJ Surg Oncol798185PubMedCrossRef
7.
Bilchik, AJ, Nora, D, Tollenaar, RA, Velde, CJ, Wood, T, Turner, R, Morton, DL, Hoon, DS 2002Ultrastaging of early colon cancer using lymphatic mapping and molecular analysisEur J Cancer38977985PubMedCrossRef
8.
Bilchik, AJ, Saha, S, Wiese, D, Stonecypher, JA, Wood, TF, Sostrin, S, Turner, RR, Wang, HJ, Morton, DL, Hoon, DS 2001Molecular staging of early colon cancer on the basis of sentinel node analysis: a multicenter phase II trialJ Clin Oncol1911281136PubMed
9.
Bilchik, AJ, Trocha, SD 2003Lymphatic mapping and sentinel node analysis to optimize laparoscopic resection and staging of colorectal cancer: an updateCancer Control10219223PubMed
10.
Bjelovic, M, Kalezic, V, Petrovic, M, Pesko, P, Usaj, SK, Marinkovic, J, Radovanovic, N 1998Correlation of macroscopic and histological characteristics in the regional lymph nodes of patients with rectal and sigmoidal adenocarcinomaHepatogastroenterology45433438PubMed
11.
Black, RB, Roberts, MM, Stewart, HJ, Prescott, R, Cant, EL, Sumerling, MD, Smith, A, Forrest, AP 1980The search for occult metastases in breast cancer: does it add to established staging methods?Aust N Z J Surg50574579PubMedCrossRef
12.
Broderick-Villa, G, Ko, A, O’Connell, TX, Guenther, JM, Danial, T, DiFronzo, LA 2002Does tumor burden limit the accuracy of lymphatic mapping and sentinel lymph node biopsy in colorectal cancer?Cancer J8445450PubMedCrossRef
13.
Broll, R, Schauer, V, Schimmelpenning, H, Strik, M, Woltmann, A, Best, R, Bruch, HP, Duchrow, M 1997Prognostic relevance of occult tumor cells in lymph nodes of colorectal carcinomas: an immunohistochemical studyDis Colon Rectum4014651471PubMedCrossRef
14.
Burchill, SA, Bradbury, MF, Pittman, K, Southgate, J, Smith, B, Selby, P 1995Detection of epithelial cancer cells in peripheral blood by reverse transcriptase–polymerase chain reactionBr J Cancer71278281PubMedPubMedCentralCrossRef
15.
Bush, ST 1997Minimum number of lymph nodes to be recovered from colorectal resection specimensAm J Clin Pathol107494PubMed
16.
17.
Caplin, S, Cerottini, JP, Bosman, FT, Constanda, MT, Givel, JC 1998For patients with Dukes’ B (TNM stage II) colorectal carcinoma, examination of six or fewer lymph nodes is related to poor prognosisCancer83666672PubMedCrossRef
18.
Cawthorn, SJ, Gibbs, NM, Marks, CG 1986Clearance technique for the detection of lymph nodes in colorectal cancerBr J Surg735860PubMedCrossRef
19.
Choi, HJ, Choi, YY, Hong, SH 2002Incidence and prognostic implications of isolated tumor cells in lymph nodes from patients with Dukes B colorectal carcinomaDis Colon Rectum45750755PubMedCrossRef
20.
Cianchi, F, Palomba, A, Boddi, V, Messerini, L, Pucciani, F, Perigli, G, Bechi, P, Cortesini, C 2002Lymph node recovery from colorectal tumor specimens: recommendation for a minimum number of lymph nodes to be examinedWorld J Surg26384389PubMedCrossRef
21.
Clarke, G, Ryan, E, Crowe, J, O’Keane, JC, MacMathuna, P 1999Immunohistochemical detection of mutant p53 protein in regional lymph nodes is associated with adverse outcome in stage II colorectal cancerEur J Histochem43311316PubMed
22.
23.
24.
Cserni, G, Vajda, K, Tarjan, M, Bori, R, Svebis, M, Baltas, B 1999Nodal staging of colorectal carcinomas from quantitative and qualitative aspects. Can lymphatic mapping help staging?Pathol Oncol Res5291296PubMedCrossRef
25.
Cserni, G, Vinh-Hung, V, Burzykowski, T 2002Is there a minimum number of lymph nodes that should be histologically assessed for a reliable nodal staging of T3N0M0 colorectal carcinomas?J Surg Oncol816369PubMedCrossRef
26.
Cutait, R, Alves, VA, Lopes, LC, Cutait, DE, Borges, JL, Singer, J, da Silva, JH, Goffi, FS 1991Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratinsDis Colon Rectum34917920PubMedCrossRef
27.
Davidson, BR, Sams, VR, Styles, J, Deane, C, Boulos, PB 1990Detection of occult nodal metastases in patients with colorectal carcinomaCancer65967970PubMedCrossRef
28.
Denis, MG, Lipart, C, Leborgne, J, LeHur, PA, Galmiche, JP, Denis, M, Ruud, E, Truchaud, A, Lustenberger, P 1997Detection of disseminated tumor cells in peripheral blood of colorectal cancer patientsInt J Cancer74540544PubMedCrossRef
29.
30.
Dorudi, S, Kinrade, E, Marshall, NC, Feakins, R, Williams, NS, Bustin, SA 1998Genetic detection of lymph node micrometastases in patients with colorectal cancerBr J Surg8598100PubMedCrossRef
31.
Dube, S, Heyen, F, Jenicek, M 1997Adjuvant chemotherapy in colorectal carcinoma: results of a meta-analysisDis Colon Rectum403541PubMedCrossRef
32.
Esser, S, Reilly, WT, Riley, LB, Eyvazzadeh, C, Arcona, S 2001The role of sentinel lymph node mapping in staging of colon and rectal cancerDis Colon Rectum44850856PubMedCrossRef
33.
Evangelista, W, Satolli, MA, Malossi, A, Mussa, B, Sandrucci, S 2002Sentinel lymph node mapping in colorectal cancer: a feasibility studyTumori883740PubMed
34.
Feezor, RJ, Copeland, EM,III, Hochwald, SN 2002Significance of micrometastases in colorectal cancerAnn Surg Oncol9944953PubMedCrossRef
35.
Feig, BW, Curley, S, Lucci, A, Hunt, KK, Vauthey, JN, Mansfield, PF, Cleary, K, Hamilton, S, Ellis, V, Brame, M, Berger, DH 2001A caution regarding lymphatic mapping in patients with colon cancerAm J Surg182707712PubMedCrossRef
36.
Fielding, LP, Arsenault, PA, Chapuis, PH, Dent, O, Gathright, B, Hardcastle, JD, Hermanek, P, Jass, JR, Newland, RC 1991Clinicopathological staging for colorectal cancer: an International Documentation System (IDS) and an International Comprehensive Anatomical Terminology (1CAT)J Gastroenterol Hepatol6325344PubMedCrossRef
37.
Filder, IJ 1997Molecular biology of cancer: invasion and metastasisDevita, VT,JrHllmann, SRosenberg, SA eds. Cancer: principles and practice of oncology (5th ed)Lippincott-RavenPhiladelphia135152
38.
Finlay, IG, McArdle, CS 1982The identification of patients at high risk following curative resection for colorectal carcinomaBr J Surg69583584PubMedCrossRef
39.
Fitzgerald, TL, Khalifa, MA, Al Zahrani, M, Law, CH, Smith, AJ 2002 Ex vivo sentinel lymph node biopsy in colorectal cancer: a feasibility studyJ Surg Oncol802732PubMedCrossRef
40.
Frankel, K 1997Minimum number of lymph nodes to be recovered from colorectal resection specimensAm J Clin Pathol107494PubMedCrossRef
41.
Futamura, M, Takagi, Y, Koumura, H, Kida, H, Tanemura, H, Shimokawa, K, Saji, S 1998Spread of colorectal cancer micrometastases in regional lymph nodes by reverse transcriptase–polymerase chain reactions for carcinoembryonic antigen and cytokeratin 20J Surg Oncol683440PubMedCrossRef
42.
Gandy, CP, Biddlestone, LR, Roe, AM, O’Leary, DP 2002Intraoperative injection of Patent Blue V dye to facilitate nodal staging in colorectal cancerColorectal Dis4447449PubMedCrossRef
43.
Gerhard, M, Juhl, H, Kalthoff, H, Schreiber, HW, Wagener, C, Neumaier, M 1994Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reactionJ Clin Oncol12725729PubMed
44.
45.
Goldstein, NS 2001Recent pathology related advances in colorectal adenocarcinomasEur J Surg27446450CrossRef
46.
Goldstein, NS, Sanford, W, Coffey, M, Layfield, LJ 1996Lymph node recovery from colorectal resection specimens removed for adenocarcinoma: trends over time and a recommendation for a minimum number of lymph nodes to be recoveredAm J Clin Pathol106209216PubMedCrossRef
47.
Gray, RJ, Cox, CE, Reintgen, DS 2001Importance of missed axillary micrometastases in breast cancer patientsBreast J7303307PubMedCrossRef
48.
Greenson, JK, Isenhart, CE, Rice, R, Mojzisik, C, Houchens, D, Martin, EW,Jr 1994Identification of occult micrometastases in pericolic lymph nodes of Duke’s B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49: correlation with long-term survivalCancer73563569PubMedCrossRef
49.
50.
Gunn, J, McCall, JL, Yun, K, Wright, PA 1996Detection of micrometastases in colorectal cancer patients by K19 and K20 reverse-transcription polymerase chain reactionLab Invest75611616PubMed
51.
Haboubi, NY, Abdalla, SA, Amini, S, Clark, P, Dougal, M, Dube, A, Schofield, P 1998The novel combination of fat clearance and immunohistochemistry improves prediction of the outcome of patients with colorectal carcinomas: a preliminary studyInt J Colorectal Dis1399102PubMedCrossRef
52.
Hayashi, N, Ito, I, Yanagisawa, A, Kato, Y, Nakamori, S, Imaoka, S, Watanabe, H, Ogawa, M, Nakamura, Y 1995Genetic diagnosis of lymph node metastasis in colorectal cancerLancet34512571259PubMedCrossRef
53.
Hermanek, P, Hutter, RV, Sobin, LH, Wittekind, C 1999Classification of isolated tumor cells and micrometastasisInternational Union Against Cancer. Cancer8626682673PubMed
54.
Hernanz, F, Revuelta, S, Redondo, C, Madrazo, C, Castillo, J, Gomez-Fleitas, M 1994Colorectal adenocarcinoma: quality of the assessment of lymph node metastasesDis Colon Rectum37373376PubMedCrossRef
55.
Herrera-Ornelas, L, Justiniano, J, Castillo, N, Petrelli, NJ, Stulc, JP, Mittelman, A 1987Metastases in small lymph nodes from colon cancerArch Surg12212531256PubMedCrossRef
56.
Hida, J, Mori, N, Kubo, R, Matsuda, T, Morikawa, E, Kitaoka, M, Sindoh, K, Yasutomi, M 1994Metastases from carcinoma of the colon and rectum detected in small lymph nodes by the clearing methodJ Am Coll Surg178223228PubMed
57.
58.
Isaka, N, Nozue, M, Doy, M, Fukao, K 1999Prognostic significance of perirectal lymph node micrometastases in Dukes’ B rectal carcinoma: an immunohistochemical study by CAM5.2Clin Cancer Res520652068PubMed
59.
Jeffers, MD, O’Dowd, GM, Mulcahy, H, Stagg, M, O’Donoghue, DP, Toner, M 1994The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinomaJ Pathol172183187PubMedCrossRef
60.
Jessup, JM, McGinnis, LS, Steele, GD,Jr, Menck, HR, Winchester, DP 1996Report on colon cancer. The National Cancer Data BaseCancer78918926PubMedCrossRef
61.
62.
Joosten, JJ, Strobbe, LJ, Wauters, CA, Pruszczynski, M, Wobbes, T, Ruers, TJ 1999Intraoperative lymphatic mapping and the sentinel node concept in colorectal carcinomaBr J Surg86482486PubMedCrossRef
63.
Joseph, NE, Sigurdson, ER, Hanlon, AL, Wang, H, Mayer, RJ, MacDonald, JS, Catalano, PJ, Haller, DG 2003Accuracy of determining nodal negativity in colorectal cancer on the basis of the number of nodes retrieved on resectionAnn Surg Oncol10213218PubMedCrossRef
64.
Koren, R, Siegal, A, Klein, B, Halpern, M, Kyzer, S, Veltman, V, Gal, R 1997Lymph node-revealing solution: simple new method for detecting minute lymph nodes in colon carcinomaDis Colon Rectum40407410PubMedCrossRef
65.
Kotanagi, H, Fukuoka, T, Shibata, Y, Yoshioka, T, Aizawa, O, Saito, Y, Tur, GE, Koyama, K 1993The size of regional lymph nodes does not correlate with the presence or absence of metastasis in lymph nodes in rectal cancerJ Surg Oncol54252254PubMedCrossRef
66.
Krook, JE, Moertel, CG, Gunderson, LL, Wieand, HS, Collins, RT, Beart, RW, Kubista, TP, Poon, MA, Meyers, WC, Mailliard, JA 1991Effective surgical adjuvant therapy for high-risk rectal carcinomaN Engl J Med324709715PubMedCrossRef
67.
Laurie, JA, Moertel, CG, Fleming, TR, Wieand, HS, Leigh, JE, Rubin, J, McCormack, GW, Gerstner, JB, Krook, JE, Malliard, J 1989Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo ClinicJ Clin Oncol714471456PubMed
68.
Le Voyer, TE, Sigurdson, ER, Hanlon, AL, Mayer, RJ, Macdonald, JS, Catalano, PJ, Haller, DG 2003Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089J Clin Oncol2129122919PubMedCrossRef
69.
Liefers, GJ, Cleton-Jansen, AM, Velde, CJ, Hermans, J, Krieken, JH, Cornelisse, CJ, Tollenaar, RA 1998Micrometastases and survival in stage II colorectal cancerN Engl J Med339223228PubMedCrossRef
70.
Litle, VR, Warren, RS, Moore, DN, Pallavicini, MG 1997Molecular cytogenetic analysis of cytokeratin 20-labeled cells in primary tumors and bone marrow aspirates from colorectal carcinoma patientsCancer7916641670PubMedCrossRef
71.
Ludwig, J 1962On bypasses of the lymphatic system and their relations to lymphogenic cancer metastasisPathol Microbiol (Basel)25329334
72.
Mainprize, KS, Kulacoglu, H, Hewavisinthe, J, Savage, A, Mortensen, N, Warren, BF 1998How many lymph nodes to stage colorectal carcinoma?J Clin Pathol51165166PubMedPubMedCentralCrossRef
73.
Maruyama, K, Sasako, M, Kinoshita, T, Sano, T, Katai, H 1999Can sentinel node biopsy indicate rational extent of lymphadenectomy in gastric cancer surgery? Fundamental and new information on lymph node dissectionLangenbecks Arch Surg384149157PubMedCrossRef
74.
Merrie, AE, Phillips, LV, Yun, K, McCall, JL 2001Skip metastases in colon cancer: assessment by lymph node mapping using molecular detectionSurgery129684691PubMedCrossRef
75.
Merrie, AE, Rij, AM, Dennett, ER, Phillips, LV, Yun, K, McCall, JL 2003Prognostic significance of occult metastases in colon cancerDis Colon Rectum46221231PubMedCrossRef
76.
Merrie, AE, Yun, K, Gunn, J, Phillips, LV, McCall, JL 1999Analysis of potential markers for detection of submicroscopic lymph node metastases in breast cancerBr J Cancer8020192024PubMedPubMedCentralCrossRef
77.
Moertel, C, Fleming, T, MacDonald, J, Haller, D, Laurie, J 1992The Intergroup study of fluorouracil (5FU) plus levamisole and levamisole alone as adjuvant therapy for stage C colon cancer: a final reportProc Am Soc Clin Oncol11161168
78.
Moertel, CG, Fleming, TR, Macdonald, JS, Haller, DG, Laurie, JA, Goodman, PJ, Ungerleider, JS, Emerson, WA, Tormey, DC, Glick, JH,  et al. 1990Levamisole and fluorouracil for adjuvant therapy of resected colon carcinomaN Engl J Med322352358PubMedCrossRef
79.
Moll, R, Lowe, A, Laufer, J, Franke, WW 1992Cytokeratin 20 in human carcinomas: a new histodiagnostic marker detected by monoclonal antibodiesAm J Pathol140427447PubMedPubMedCentral
80.
Monig, SP, Baldus, SE, Zirbes, TK, Schroder, W, Lindemann, DG, Dienes, HP, Holscher, AH 1999Lymph node size and metastatic infiltration in colon cancerAnn Surg Oncol6579581PubMedCrossRef
81.
Morton, DL, Hoon, DS, Cochran, AJ, Turner, RR, Essner, R, Takeuchi, H, Wanek, LA, Glass, E, Foshag, LJ, Hsueh, EC, Bilchik, AJ, Elashoff, D, Elashoff, R 2003Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastasesAnn Surg238538549PubMedPubMedCentral
82.
Morton, DL, Wen, DR, Wong, JH, Economou, JS, Cagle, LA, Storm, FK, Foshag, LJ, Cochran, AJ 1992Technical details of intraoperative lymphatic mapping for early stage melanomaArch Surg127392399PubMedCrossRef
83.
Nagle, RB 1988Intermediate filaments: a review of the basic biologyAm J Surg Pathol12416PubMed
84.
Nakanishi, Y, Ochiai, A, Yamauchi, Y, Moriya, Y, Yoshimura, K, Hirohashi, S 1999Clinical implications of lymph node micrometastases in patients with colorectal cancers: a case–control studyOncology57276280PubMedCrossRef
85.
Natsugoe, S, Aiko, T, Shimazu, H 1991A detailed histological study on occult metastasis of the lymph nodesJpn J Surg21528532PubMedCrossRef
86.
Nelson, H, Petrelli, N, Carlin, A, Couture, J, Fleshman, J, Guillem, J, Miedema, B, Ota, D, Sargent, D 2001Guidelines 2000 for colon and rectal cancer surgery. National Cancer Institute Expert PanelJ Natl Cancer Inst93583596PubMedCrossRef
87.
Nieweg, OE, Tanis, PJ, Kroon, BB 2001The definition of a sentinel nodeAnn Surg Oncol8538541PubMedCrossRef
88.
NIH Consensus Conference1990Adjuvant therapy for patients with colon and rectal cancerJAMA26414441450CrossRef
89.
Oberg, A, Stenling, R, Tavelin, B, Lindmark, G 1998Are lymph node micrometastases of any clinical significance in Dukes Stages A and B colorectal cancer?Dis Colon Rectum4112441249PubMedCrossRef
90.
Paraf, F, Sabourin, JC 2000Optimal lymph node number and occult lymph node metastases in colorectal cancer: the pathologist’s viewGastroenterol Clin Biol24423459PubMed
91.
Paramo, JC, Summerall, J, Poppiti, R, Mesko, TW 2002Validation of sentinel node mapping in patients with colon cancerAnn Surg Oncol9550554PubMedCrossRef
92.
Paramo, JC, Summerall, J, Wilson, C, Cabral, A, Willis, I, Wodnicki, H, Poppiti, R, Mesko, TW 2001Intraoperative sentinel lymph node mapping in patients with colon cancerAm J Surg1824043PubMedCrossRef
93.
Poller, DN 2000Method of specimen fixation and pathological dissection of colorectal cancer influences retrieval of lymph nodes and tumor nodal stageEur J Surg Oncol26758762PubMedCrossRef
94.
Prandi, M, Lionetto, R, Bini, A, Francioni, G, Accarpio, G, Anfossi, A, Ballario, E, Becchi, G, Bonilauri, S, Carobbi, A, Cavaliere, P, Garcea, D, Giuliani, L, Morziani, E, Mosca, F, Mussa, A, Pasqualini, M, Poddie, D, Tonetti, F, Zardo, L, Rosso, R 2002Prognostic evaluation of stage B colon cancer patients is improved by an adequate lymphadenectomy: results of a secondary analysis of a large-scale adjuvant trialAnn Surg235458463PubMedPubMedCentralCrossRef
95.
Ratto, C, Sofo, L, Ippoliti, M, Merico, M, Bossola, M, Vecchio, FM, Doglietto, GB, Crucitti, F 1999Accurate lymph-node detection in colorectal specimens resected for cancer is of prognostic significanceDis Colon Rectum42143154, discussion 154–158PubMedCrossRef
96.
Rodier, JF, Routiot, T, Mignotte, H, Janser, JC, Bremond, A, David, E, Barlier, C, Ghnassia, JP, Treilleux, I, Chassagne, C, Velten, M 2000Lymphatic mapping and sentinel node biopsy of operable breast cancerWorld J Surg2412201226PubMedCrossRef
97.
Rodriguez-Bigas, MA, Maamoun, S, Weber, TK, Penetrante, RB, Blumenson, LE, Petrelli, NJ 1996Clinical significance of colorectal cancer: metastases in lymph nodes < 5 mm in sizeAnn Surg Oncol3124130PubMedCrossRef
98.
Rosenberg, R, Friederichs, J, Gertler, R, Hoos, A, Mueller, J, Nahrig, J, Nekarda, H, Siewert, JR 2004Prognostic evaluation and review of immunohistochemically detected disseminated tumor cells in peritumoral lymph nodes of patients with pN0 colorectal cancerInt J Colorectal Dis19930937CrossRef
99.
Rouffet, F, Hay, JM, Vacher, B, Fingerhut, A, Elhadad, A, Flamant, Y, Mathon, C, Gainant, A 1994Curative resection for left colonic carcinoma: hemicolectomy vs segmental colectomy: a prospective, controlled, multicenter trial. French Association for Surgical ResearchDis Colon Rectum37651659PubMedCrossRef
100.
Saha, S, Bilchik, A, Wiese, D, Espinosa, M, Badin, J, Ganatra, BK, Desai, D, Kaushal, S, Singh, T, Arora, M 2001Ultrastaging of colorectal cancer by sentinel lymph node mapping technique: a multicenter trialAnn Surg Oncol894S98SPubMed
101.
Saha, S, Nora, D, Wong, JH, Weise, D 2000Sentinel lymph node mapping in colorectal cancer: a reviewSurg Clin North Am8018111819PubMedCrossRef
102.
Saha, S, Wiese, D, Badin, J, Beutler, T, Nora, D, Ganatra, BK, Desai, D, Kaushal, S, Nagaraju, M, Arora, M, Singh, T 2000Technical details of sentinel lymph node mapping in colorectal cancer and its impact on stagingAnn Surg Oncol7120124PubMedCrossRef
103.
Scott, KW, Grace, RH, Gibbons, P 1994Five-year follow-up study of the fat clearance technique in colorectal carcinomaDis Colon Rectum37126128PubMedCrossRef
104.
Sobin, LH 1999Frequently asked questions regarding the application of the TNM classification. TNM/Prognostic Factors Project (International Union Against Cancer [UICC])Cancer8514051406PubMedCrossRef
105.
Sobin, LH, Greene, FL 2001TNM classification: clarification of number of regional lymph nodes for pNoCancer92452PubMedCrossRef
106.
Tarin, D 1995Cancer metastasisPeckham, MPinedo, HVeronesi, U eds. Oxford textbook of oncologyOxford University PressOxford118132
107.
Taylor, A,Jr, Murray, D, Herda, S, Vansant, J, Alazraki, N 1996Dynamic lymphoscintigraphy to identify the sentinel and satellite nodesClin Nucl Med21755758PubMedCrossRef
108.
Tepper, JE, O’Connell, MJ, Niedzwiecki, D, Hollis, D, Compton, C, Benson, AB,III, Cummings, B, Gunderson, L, Macdonald, JS, Mayer, RJ 2001Impact of number of nodes retrieved on outcome in patients with rectal cancerJ Clin Oncol19157163PubMed
109.
Thorn, M 2000Lymphatic mapping and sentinel node biopsy: is the method applicable to patients with colorectal and gastric cancer?Eur J Surg166755758PubMedCrossRef
110.
Tsavellas, G, Patel, H, Allen-Mersh, TG 2001Detection and clinical significance of occult tumor cells in colorectal cancerBr J Surg8813071320PubMedCrossRef
111.
Tschmelitsch, J, Klimstra, DS, Cohen, AM 2000Lymph node micrometastases do not predict relapse in stage II colon cancerAnn Surg Oncol7601608PubMedCrossRef
112.
Tsioulias, GJ, Wood, TF, Morton, DL, Bilchik, AJ 2000Lymphatic mapping and focused analysis of sentinel lymph nodes upstage gastrointestinal neoplasmsArch Surg135926932PubMedCrossRef
113.
Tsioulias, GJ, Wood, TF, Spirt, M, Morton, DL, Bilchik, AJ 2002A novel lymphatic mapping technique to improve localization and staging of early colon cancer during laparoscopic colectomyAm Surg68561565PubMed
114.
Tuech, JJ, Regenet, N, Ollier, JC, Rodier, JF 2003Sentinel lymph node mapping in colorectal cancerGastroenterol Clin Biol27204211PubMed
115.
Turner, RR, Ollila, DW, Stern, S, Giuliano, AE 1999Optimal histopathologic examination of the sentinel lymph node for breast carcinoma stagingAm J Surg Pathol23263267PubMedCrossRef
116.
Veronesi, U, Paganelli, G, Galimberti, V, Viale, G, Zurrida, S, Bedoni, M, Costa, A, Cicco, C, Geraghty, JG, Luini, A, Sacchini, V, Veronesi, P 1997Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph nodesLancet34918641867PubMedCrossRef
117.
Viehl, CT, Hamel, CT, Marti, WR, Guller, U, Eisner, L, Stammberger, U, Terracciano, L, Spichtin, HP, Harder, F, Zuber, M 2003Identification of sentinel lymph nodes in colon cancer depends on the amount of dye injected relative to tumor sizeWorld J Surg2712851290PubMedCrossRef
118.
Waldman, SA, Cagir, B, Rakinic, J, Fry, RD, Goldstein, SD, Isenberg, G, Barber, M, Biswas, S, Minimo, C, Palazzo, J, Park, PK, Weinberg, D 1998Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancerDis Colon Rectum41310315PubMedCrossRef
119.
Waters, GS, Geisinger, KR, Garske, DD, Loggie, BW, Levine, EA 2000Sentinel lymph node mapping for carcinoma of the colon: a pilot studyAm Surg66943946PubMed
120.
Weitz, J, Kienle, P, Magener, A, Koch, M, Schrodel, A, Willeke, F, Autschbach, F, Lacroix, J, Lehnert, T, Herfarth, C, Knebel Doeberitz, M 1999Detection of disseminated colorectal cancer cells in lymph nodes, blood and bone marrowClin Cancer Res518301836PubMed
121.
Wiese, DA, Saha, S, Badin, J, Ng, PS, Gauthier, J, Ahsan, A, Yu, L 2000Pathologic evaluation of sentinel lymph nodes in colorectal carcinomaArch Pathol Lab Med12417591763PubMed
122.
123.
Wong, JH, Severino, R, Honnebier, MB, Tom, P, Namiki, TS 1999Number of nodes examined and staging accuracy in colorectal carcinomaJ Clin Oncol1728962900PubMed
124.
Wong, JH, Steineman, S, Calderia, C, Bowles, J, Namiki, T 2001 Ex vivo sentinel node mapping in carcinoma of the colon and rectumAnn Surg233515521PubMedPubMedCentralCrossRef
125.
Wong, LS, Morris, AG, Fraser, IA 1997Detection of occult nodal metastases in patients with colorectal cancerBr J Surg841432PubMedCrossRef
126.
Wood, TF, Saha, S, Morton, DL, Tsioulias, GJ, Rangel, D, Hutchinson, W,Jr, Foshag, LJ, Bilchik, AJ 2001Validation of lymphatic mapping in colorectal cancer: in vivo, ex vivo, and laparoscopic techniquesAnn Surg Oncol8150157PubMedCrossRef
127.
Wood, TF, Spirt, M, Rangel, D, Shen, P, Tsioulias, GJ, Morton, DL, Bilchik, AJ 2001Lymphatic mapping improves staging during laparoscopic colectomy for cancerSurg Endosc15715719PubMedCrossRef
128.
Wood, TF, Tsioulias, GJ, Morton, DL, Rangel, D, Hutchinson, W,Jr, Foshag, LJ, Turner, RR, Bilchik, AJ 2000Focused examination of sentinel lymph nodes upstages early colorectal carcinomaAm Surg669981003PubMed
129.
Yao, KA, Hsueh, EC, Essner, R, Foshag, LJ, Wanek, LA, Morton, DL 2003Is sentinel lymph node mapping indicated for isolated local and in-transit recurrent melanoma?Ann Surg238743747PubMedPubMedCentralCrossRef
130.
Yasuda, K, Adachi, Y, Shiraishi, N, Yamaguchi, K, Hirabayashi, Y, Kitano, S 2001Pattern of lymph node micrometastasis and prognosis of patients with colorectal cancerAnn Surg Oncol8300304PubMedCrossRef
Metadata
Title
Sentinel lymph node mapping in colon cancer
Authors
J.-J. Tuech
P. Pessaux
N. Regenet
R. Bergamaschi
A. Colson
Publication date
01-12-2004
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 12/2004
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-004-9031-6

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