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Published in:

01-05-2003

The percentage of CD31⁺ T cells decreases after open but not laparoscopic surgery

Authors: I. Kirman, V. Cekic, N. Poltaratskaia, Z. Asi, S. Conte, D. Feingold, K. A. Forde, E. H. Huang, R. L. Whelan

Published in: Surgical Endoscopy | Issue 5/2003

Abstract

Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3⁺CD31⁺ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31⁺ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3⁺CD31⁺ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3⁺CD31⁺ cells and the length of incision in OS patients. Conclusions: The percentage of CD3⁺CD31⁺ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.

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Title: The percentage of CD31+ T cells decreases after open but not laparoscopic surgery
Authors: I. Kirman
V. Cekic
N. Poltaratskaia
Z. Asi
S. Conte
D. Feingold
K. A. Forde
E. H. Huang
R. L. Whelan
Publication date: 01-05-2003
Publisher: Springer-Verlag
Published in: Surgical Endoscopy / Issue 5/2003
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-002-8942-3

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