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01-10-2021 | Expectoration | Original Article

Pharyngeal Deposits Comprising Salivary Mucin in Tube-fed Elderly Patients: MUC2 and MUC7 Immunoreactivity

Authors: Kohta Miyahara, Tadashi Ogasawara, Hiromasa Hasegawa, Kohichi Shinotsuka, Katsumitsu Shimada, Takanaga Ochiai, Fa-Chih Shen, Yasuaki Kakinoki

Published in: Dysphagia | Issue 5/2021

Abstract

Several investigators have reported that oral membranous and pharyngeal viscous deposits developed in bedridden elderly persons requiring nursing care without oral intake. Therefore, this study aimed to clarify the origin of viscous deposits on the pharyngeal mucosa based on characteristics of salivary and tracheal secretory mucin. The participants were 35 elderly people who required nursing care. All 46 collected specimens, including 30 intraoral and 16 pharyngeal specimens, were stained against specific mucins secreted from the respiratory tract and saliva gland using antibodies anti-MUC2 and anti-MUC7, respectively. Out of 35 participants, the intraoral membranous deposits and deposits on the pharyngeal mucosa developed in 17 (48.6%) and 10 persons (28.6%), respectively. The pharyngeal deposits developed in 58.8% of participants who developed intraoral deposits. All pathological specimens shared microscopic findings of various combinations of eosinophilic lamellar structure and a pale-basophilic amorphous substance. Immunohistochemically, both the 30 oral and the 16 pharyngeal specimens obtained from 17 participants were consistently positive for MUC7 but negative for MUC2. In conclusion, we clarified that the mucoid component of both oral and pharyngeal deposits comprised MUC7 salivary mucin, which revealed that both deposits originated from the oral cavity. This result strongly suggests that oral care is intimately related to oral and pharyngeal conditions.

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Title: Pharyngeal Deposits Comprising Salivary Mucin in Tube-fed Elderly Patients: MUC2 and MUC7 Immunoreactivity
Authors: Kohta Miyahara
Tadashi Ogasawara
Hiromasa Hasegawa
Kohichi Shinotsuka
Katsumitsu Shimada
Takanaga Ochiai
Fa-Chih Shen
Yasuaki Kakinoki
Publication date: 01-10-2021
Publisher: Springer US
Keyword: Expectoration
Published in: Dysphagia / Issue 5/2021
Print ISSN: 0179-051X
Electronic ISSN: 1432-0460
DOI: https://doi.org/10.1007/s00455-020-10202-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pharyngeal Deposits Comprising Salivary Mucin in Tube-fed Elderly Patients: MUC2 and MUC7 Immunoreactivity

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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