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Dysphagia
Published in: Dysphagia 1/2013

01-03-2013 | Original Article

Videofluorographic Assessment of Deglutitive Behaviors in a Rat Model of Aging and Parkinson Disease

Authors: John A. Russell, Michelle R. Ciucci, Michael J. Hammer, Nadine P. Connor

Published in: Dysphagia | Issue 1/2013

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Abstract

Dysphagia is commonly associated with aging and Parkinson disease and can have a significant impact on a person’s quality of life. In some cases, dysphagia may be life-threatening. Animal models may be used to study underlying mechanisms of dysphagia, but paradigms that allow adequate imaging of the swallow in combination with measurement of physiological variables have not been forthcoming. To begin development of methods that allow this, we used videofluorography to record the deglutition behaviors of 22 Fisher 344/Brown Norway rats in young adult (9 months old), old (32 months old), and parkinsonian (unilateral lesion to the medial forebrain bundle) groups. We hypothesized that the old and parkinsonian rats would manifest deficits in deglutition behaviors analogous to those found in human clinical populations. Our results supported our hypothesis in that the old group demonstrated reductions in bolus transport speeds and mastication rate while the parkinsonian rats showed impairments in oral processing. Interpretation of these results should consider the particular animal model, lesion type, and videofluorographic protocol used in this work. Future studies will link swallow imaging data of this kind with physiological and anatomical data in a manner not possible with human participants.
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Metadata
Title
Videofluorographic Assessment of Deglutitive Behaviors in a Rat Model of Aging and Parkinson Disease
Authors
John A. Russell
Michelle R. Ciucci
Michael J. Hammer
Nadine P. Connor
Publication date
01-03-2013
Publisher
Springer-Verlag
Published in
Dysphagia / Issue 1/2013
Print ISSN: 0179-051X
Electronic ISSN: 1432-0460
DOI
https://doi.org/10.1007/s00455-012-9417-x

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