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Open Access 01-08-2020 | Bronchitis | Short Communication

Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

Authors: Egbert Herting, Angela Kribs, Christoph Härtel, Axel von der Wense, Ursula Weller, Thomas Hoehn, Matthias Vochem, Jens Möller, Christian Wieg, Bernhard Roth, Wolfgang Göpel, for the German Neonatal Network (GNN)

Published in: European Journal of Pediatrics | Issue 8/2020

Abstract

Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment.

Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.

What is Known: • LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.
What is New: • Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.

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Title: Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
Authors: Egbert Herting
Angela Kribs
Christoph Härtel
Axel von der Wense
Ursula Weller
Thomas Hoehn
Matthias Vochem
Jens Möller
Christian Wieg
Bernhard Roth
Wolfgang Göpel
for the German Neonatal Network (GNN)
Publication date: 01-08-2020
Publisher: Springer Berlin Heidelberg
Keyword: Bronchitis
Published in: European Journal of Pediatrics / Issue 8/2020
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-020-03572-0

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Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

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