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01-04-2019 | Meningitis | Original Article

Human parechovirus meningitis and gross-motor neurodevelopment in young children

Authors: Ted M. T. van Hinsbergh, Stephanie C. M. de Crom, Robert Lindeboom, Marceline A. M. van Furth, Charlie C. Obihara

Published in: European Journal of Pediatrics | Issue 4/2019

Abstract

This multicenter prospective cohort study describes the impact of human parechovirus meningitis on gross-motor neurodevelopment of young children. Gross-motor function was measured using Alberta Infant Motor Scale. Of a total of 38 eligible children < 10 months of age at onset, nine cases had clinical evidence of meningitis and polymerase chain reaction positive for human parechovirus in cerebrospinal fluid; 11 had no meningitis and polymerase chain reaction positive for human parechovirus in nasopharyngeal aspirate, blood, urine, or feces; and in 18, no pathogen was identified (reference group).

The children with human parechovirus meningitis showed more frequent albeit not statistically significant suspect gross-motor function delay (mean Z-score (standard deviation) − 1.69 (1.05)) than children with human parechovirus infection-elsewhere (− 1.38 (1.51)). The reference group did not fall in the range of suspect gross-motor function delay (− 0.96 (1.07)). Adjustment for age at onset and maternal education did not alter the results.

Conclusion: Six months after infection, children with human parechovirus meningitis showed more frequent albeit not statistically significant suspect gross-motor function delay compared to the population norm and other two groups. Longitudinal studies in larger samples and longer follow-up periods are needed to confirm the impact and persistence of human parechovirus meningitis on neurodevelopment in young children.

What is Known:

• Human parechovirus is progressively becoming a major viral cause of meningitis in children.

• There is keen interest in the development of affected infants with human parechovirus meningitis.

What is New:

• This study describes prospectively gross-motor functional delay in children with both clinical evidence of meningitis and polymerase chain reaction positive for human parechovirus in cerebrospinal fluid.

• It shows the importance of screening young children for developmental delay in order to refer those with delay for early intervention to maximize their developmental potential.

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Title: Human parechovirus meningitis and gross-motor neurodevelopment in young children
Authors: Ted M. T. van Hinsbergh
Stephanie C. M. de Crom
Robert Lindeboom
Marceline A. M. van Furth
Charlie C. Obihara
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Keyword: Meningitis
Published in: European Journal of Pediatrics / Issue 4/2019
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-019-03319-6

ACC 2024 Congress

Springer Medicine

Human parechovirus meningitis and gross-motor neurodevelopment in young children

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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