Top

Published in:

01-10-2018 | Original Article

Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status

Authors: Kansuda Ariyawatkul, Porntita Lersbuasin

Published in: European Journal of Pediatrics | Issue 10/2018

Abstract

Vitamin D deficiency is common in Southeast Asia but there are limited data in pregnant women and neonates. This study aimed to determine the prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status. A total of 94 pregnant women and their neonates were included. Clinical data and venous maternal blood for calcium, phosphate, albumin, alkaline phosphatase, magnesium, intact parathyroid hormone (iPTH), and vitamin D (25OHD) were obtained on the day of labor. Cord blood was collected following delivery to evaluate vitamin D status of newborns. Mean serum maternal and cord blood 25OHD levels were 25.42 ± 8.07 and 14.85 ± 5.13 ng/mL. The prevalence of vitamin D deficiency (25OHD < 12 ng/mL) and insufficiency (25OHD 12–20 ng/mL) in cord blood of newborns were 20.2 and 69.1%, respectively. There was a significant correlation between maternal and cord blood vitamin D levels (r = 0.86; P < 0.001). The factors associated with cord blood vitamin D deficiency were low maternal 25OHD level and no vitamin D supplement during pregnancy.

Conclusion: There is a high prevalence of vitamin D deficiency among Thai neonates. Adequate prenatal vitamin D supplementation should be implemented as routine antenatal care.

What is Known: • Vitamin D deficiency is prevalent in Southeast Asia. • There are widespread vitamin D deficiency among Thai populations including pregnant women.
What is New: • There is a high prevalence of vitamin D deficiency among Thai neonates. • The factors associated with cord blood vitamin D deficiency are low maternal vitamin D level and no vitamin D supplement during pregnancy.

Chailurkit LO, Aekplakorn W, Ongphiphadhanakul B (2011) Regional variation and determinants of vitamin D status in sunshine-abundant Thailand. BMC Public Health 11:853. https://doi.org/10.1186/1471-2458-11-853 CrossRefPubMedPubMedCentral

Chailurkit LO, Kruavit A, Rajatanavin R (2011) Vitamin D status and bone health in healthy Thai elderly women. Nutrition 27(2):160–164. https://doi.org/10.1016/j.nut.2009.12.001 CrossRefPubMed

Charatcharoenwitthaya N, Nanthakomon T, Somprasit C, Chanthasenanont A, Chailurkit LO, Pattaraarchachai J, Ongphiphadhanakul B (2013) Maternal vitamin D status, its associated factors and the course of pregnancy in Thai women. Clin Endocrinol 78(1):126–133. https://doi.org/10.1111/j.1365-2265.2012.04470.x CrossRef

do Prado MR, Oliveira Fde C, Assis KF, Ribeiro SA, do Prado Junior PP, Sant’Ana LF, Priore SE, Franceschini Sdo C (2015) Prevalence of vitamin D deficiency and associated factors in women and newborns in the immediate postpartum period. Rev Paul Pediatr 33(3):287–294. https://doi.org/10.1016/j.rpped.2015.01.006 CrossRefPubMed

Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281. https://doi.org/10.1056/NEJMra070553 CrossRefPubMed

Jacquemyn Y, Ajaji M, Karepouan N (2013) Vitamin D levels in maternal serum and umbilical cord blood in a multi-ethnic population in Antwerp, Belgium. Facts Views Vis Obgyn 5(1):3–5PubMedPubMedCentral

Kovacs CS (2008) Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies. Am J Clin Nutr 88(2):520S–528SCrossRefPubMed

Kumar P, Shenoi A, Kumar RK, Girish SV, Subbaiah S (2015) Vitamin D deficiency among women in labor and cord blood of newborns. Indian Pediatr 52(6):530–531PubMed

Manzano Varo C, Garcia-Algar O, Mur Sierra A, Ferrer Costa R, Carrascosa Lezcano A, Yeste Fernandez D, Ortigosa Gomez S (2017) Plasma 25-OH vitamin D concentrations in cord blood after summer months, Spain. Rev Esp Salud Publica 91

10.

Marshall I, Mehta R, Ayers C, Dhumal S, Petrova A (2016) Prevalence and risk factors for vitamin D insufficiency and deficiency at birth and associated outcome. BMC Pediatr 16(1):208. https://doi.org/10.1186/s12887-016-0741-4 CrossRefPubMedPubMedCentral

11.

Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Makitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Savendahl L, Khadgawat R, Pludowski P, Maddock J, Hypponen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Hogler W (2016) Global consensus recommendations on prevention and management of nutritional rickets. J Clin Endocrinol Metab 101(2):394–415. https://doi.org/10.1210/jc.2015-2175 CrossRefPubMedPubMedCentral

12.

Nimitphong H, Holick MF (2013) Vitamin D status and sun exposure in Southeast Asia. Dermato-endocrinology 5(1):34–37. https://doi.org/10.4161/derm.24054 CrossRefPubMedPubMedCentral

13.

Nimitphong H, Chailurkit LO, Chanprasertyothin S, Sritara P, Ongphiphadhanakul B (2013) The association of vitamin D status and fasting glucose according to body fat mass in young healthy Thais. BMC Endocr Disord 13:60. https://doi.org/10.1186/1472-6823-13-60 CrossRefPubMedPubMedCentral

14.

Parlak M, Kalay S, Kalay Z, Kirecci A, Guney O, Koklu E (2015) Severe vitamin D deficiency among pregnant women and their newborns in Turkey. J Matern Fetal Neonatal Med 28(5):548–551. https://doi.org/10.3109/14767058.2014.924103 CrossRefPubMed

15.

Pratumvinit B, Wongkrajang P, Wataganara T, Hanyongyuth S, Nimmannit A, Chatsiricharoenkul S, Manonukul K, Reesukumal K (2015) Maternal vitamin D status and its related factors in pregnant women in Bangkok, Thailand. PLoS One 10(7):e0131126. https://doi.org/10.1371/journal.pone.0131126 CrossRefPubMedPubMedCentral

16.

Rojroongwasinkul N, Kijboonchoo K, Wimonpeerapattana W, Purttiponthanee S, Yamborisut U, Boonpraderm A, Kunapan P, Thasanasuwan W, Khouw I (2013) SEANUTS: the nutritional status and dietary intakes of 0.5-12-year-old Thai children. Br J Nutr 110(Suppl 3):S36–S44. https://doi.org/10.1017/S0007114513002110 CrossRefPubMed

17.

Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V (2005) High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr 81(5):1060–1064CrossRefPubMed

18.

Vinkhuyzen AA, Eyles DW, Burne TH, Blanken LM, Kruithof CJ, Verhulst F, Jaddoe VW, Tiemeier H, McGrath JJ (2015) Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: The Generation R Study. J Steroid Biochem Mol Biol 164:161–167. https://doi.org/10.1016/j.jsbmb.2015.09.018 CrossRefPubMed

19.

Wacker M, Holick MF (2013) Sunlight and vitamin D: a global perspective for health. Dermato-endocrinology 5(1):51–108. https://doi.org/10.4161/derm.24494 CrossRefPubMedPubMedCentral

20.

Woolcott CG, Giguere Y, Weiler HA, Spencer A, Forest JC, Armson BA, Dodds L (2016) Determinants of vitamin D status in pregnant women and neonates. Can J Public Health 107(4–5):e410–e416. https://doi.org/10.17269/cjph.107.5629 CrossRefPubMedPubMedCentral

Title: Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status
Authors: Kansuda Ariyawatkul
Porntita Lersbuasin
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 10/2018
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-018-3210-2

ACC 2024 Congress

Springer Medicine

Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 10/2018

Unhealthy eating habits and participation in organized leisure-time activities in Czech adolescents

Preliminary experience with tigecycline treatment for severe infection in children

Diagnosis of congenital and acquired focal lesions in the neck, abdomen, and pelvis with contrast-enhanced ultrasound: a pictorial essay

Effect of a community-based childhood obesity intervention program on changes in anthropometric variables, incidence of obesity, and lifestyle choices in Spanish children aged 8 to 10 years

Fitness and academic performance in adolescents. The mediating role of leptin: DADOS study

Managing cyclic vomiting syndrome in children: beyond the guidelines