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01-05-2018 | Review

The diagnostic accuracy of presepsin in neonatal sepsis: a meta-analysis

Authors: Ioannis Bellos, Georgia Fitrou, Vasilios Pergialiotis, Nikolaos Thomakos, Despina N. Perrea, Georgios Daskalakis

Published in: European Journal of Pediatrics | Issue 5/2018

Abstract

There is growing evidence that presepsin is a promising biomarker in the diagnosis of sepsis in adults. The objective of our study is to investigate current evidence related to the diagnostic accuracy of presepsin in neonatal sepsis. To accomplish this, we searched the Medline (1966–2017), Scopus (2004–2017), Clinicaltrials.gov (2008–2017), EMBASE (1980–2017), Cochrane Central Register of Controlled Trials CENTRAL (1999–2017), and Google Scholar (2004–2017) databases. Eleven studies were included in the present meta-analysis, with a total number of 783 neonates. The pooled sensitivity of serum presepsin for the prediction of neonatal sepsis was 0.91 (95% CI [0.87–0.93]) and the pooled specificity was 0.91 (95% CI [0.88–0.94]). The diagnostic odds ratio was 170.28 (95% CI [51.13–567.11]) and the area under the curve (AUC) was 0.9751 (SE 0.0117). Head-to-head comparison with AUC values of C-reactive protein (0.9748 vs. 0.8580) and procalcitonin (0.9596 vs. 0.7831) revealed that presepsin was more sensitive in detecting neonatal sepsis.

Conclusion: Current evidence support the use of presepsin in the early neonatal period in high-risk populations as its diagnostic accuracy seems to be high in detecting neonatal sepsis.

What is known:

• Neonatal sepsis is a leading cause of morbidity and mortality.

• Current laboratory tests cannot accurately discriminate endangered neonates.

What is new:

• The diagnostic odds ratio of presepsin is 170.28 and the area under the curve is 0.9751.

• According to our meta-analysis, presepsin is a useful protein that may help clinicians identify neonates at risk.

Available only for authorised users

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Title: The diagnostic accuracy of presepsin in neonatal sepsis: a meta-analysis
Authors: Ioannis Bellos
Georgia Fitrou
Vasilios Pergialiotis
Nikolaos Thomakos
Despina N. Perrea
Georgios Daskalakis
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 5/2018
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-018-3114-1

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The diagnostic accuracy of presepsin in neonatal sepsis: a meta-analysis

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