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01-10-2017 | Original Article

Treatment of severe psoriasis in children: recommendations of an Italian expert group

Authors: Anna Belloni Fortina, Federico Bardazzi, Samantha Berti, Claudia Carnevale, Vito Di Lernia, Maya El Hachem, Iria Neri, Carlo Mario Gelmetti, Viviana Lora, Carlo Mazzatenta, Mirella Milioto, Gaia Moretta, Annalisa Patrizi, Ketty Peris, Alberto Villani

Published in: European Journal of Pediatrics | Issue 10/2017

Abstract

This article provides comprehensive recommendations for the systemic treatment of severe pediatric psoriasis based on evidence obtained from a systematic review of the literature and the consensus opinion of expert dermatologists and pediatricians. For each systemic treatment, the grade of recommendation (A, B, C) based on the treatment’s approval by the European Medicines Agency for childhood psoriasis and the experts’ opinions is discussed. The grade of recommendation for narrow-band-ultraviolet B phototherapy, cyclosporine, and retinoids is C, while that for methotrexate is C/B. The use of adalimumab, etanercept, and ustekinumab has a grade A recommendation. No conventional systemic treatments are approved for pediatric psoriasis. Adalimumab is approved by the European Medicines Agency as a first-line treatment for severe chronic plaque psoriasis in children (≥ 4 years old) and adolescents. Etanercept and ustekinumab are approved as second-line therapy in children ≥ 6 and ≥ 12 years, respectively.

Conclusion: A treatment algorithm as well as practical tools (i.e., tabular summaries of differential diagnoses, treatment mechanism of actions, dosing regimens, control parameters) are provided to assist in therapeutic reasoning and decision-making for individual patients. These treatment recommendations are endorsed by major Italian Pediatric and Dermatology Societies.

What is Known:

• Guidelines for the treatment of severe pediatric psoriasis are lacking and most traditional systemic treatments are not approved for use in young patients. Although there has been decades of experience with some of the traditional agents such as phototherapy, acitretin, and cyclosporine in children, there are no RCTs on their pediatric use while RCTs investigating new biologic agents have been performed.

What is New:

• In this manuscript, an Italian multidisciplinary team of experts focused on treatment recommendations for severe forms of psoriasis in children based on an up-to-date review of the literature and experts’ opinions.

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Title: Treatment of severe psoriasis in children: recommendations of an Italian expert group
Authors: Anna Belloni Fortina
Federico Bardazzi
Samantha Berti
Claudia Carnevale
Vito Di Lernia
Maya El Hachem
Iria Neri
Carlo Mario Gelmetti
Viviana Lora
Carlo Mazzatenta
Mirella Milioto
Gaia Moretta
Annalisa Patrizi
Ketty Peris
Alberto Villani
Publication date: 01-10-2017
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 10/2017
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-017-2985-x

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Springer Medicine

Treatment of severe psoriasis in children: recommendations of an Italian expert group

Abstract

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Springer Medicine

Abstract

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