Published in:
Open Access 01-10-2017 | Case Report
Pneumococcal meningitis and endocarditis in an infant: possible improved survival with factor V Leiden mutation
Published in: European Journal of Pediatrics | Issue 10/2017
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Streptococcus pneumoniae infections continue to remain associated with high morbidity and mortality. Although the incidence of invasive meningeal and/or lung disease are not uncommon, Streptococcus pneumoniae endocarditis is rare especially in healthy pediatric population. New studies have suggested a strong association between factor V leiden (FVL) mutation and favorable outcomes in critically ill children. A healthy 10 month old presented with sepsis and meningeal signs, was later confirmed to have Streptococcus pneumoniae meningitis and endocarditis. She was found to have factor V leiden mutation and made a complete recovery despite initial complications.
Conclusion: Presence of factor V leiden mutation in critically ill children with severe septicaemia possibly contributes to better outcomes.
What is known:
• Mortality and morbidity remain high with invasive pneumococcal disease. • Pneumococcal endocarditis is rare in healthy pediatric population and results in significant morbidity and mortality |
What is new:
• New studies have suggested a strong association between factor V leiden (FVL) mutation and favorable outcomes in critically ill children. • The presence of factor V mutation in children with extensive invasive pneumococcal disease possibly contributes to a better outcome. |