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European Journal of Pediatrics
Published in: European Journal of Pediatrics 2/2017

01-02-2017 | Original Article

(Pro)renin and (pro)renin receptor expression during kidney development in neonates

Authors: Tomomasa Terada, Maki Urushihara, Takahiko Saijo, Ryuji Nakagawa, Shoji Kagami

Published in: European Journal of Pediatrics | Issue 2/2017

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Abstract

Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates were stronger than those in minor glomerular abnormalities.
Conclusion: (P)RR may play a pivotal role in prenatal renal development in humans.
What is Known:
• Renal renin-angiotensin system (RAS) has several pathophysiologic functions not only in blood pressure regulation but also in pediatric renal disease.
• Renal RAS activation plays a key role of renal development during gestation.
What is New :
• Plasma (pro)renin and soluble (pro)renin receptor (s(P)RR) levels in cord blood were significantly higher in preterm neonates than in full-term neonates.
• Immunohistochemical analysis of kidney tissue indicated that renal expression levels of (P)RR in neonates were stronger than in minor glomerular abnormalities.
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Metadata
Title
(Pro)renin and (pro)renin receptor expression during kidney development in neonates
Authors
Tomomasa Terada
Maki Urushihara
Takahiko Saijo
Ryuji Nakagawa
Shoji Kagami
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 2/2017
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-016-2820-9

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