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01-12-2016 | Short Communication

Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin

Authors: Gulsah Kaya Aksoy, Mustafa Koyun, Bahar Akkaya, Elif Comak, Atilla Gemici, Sema Akman

Published in: European Journal of Pediatrics | Issue 12/2016

Abstract

Drug-related acute tubulointerstitial nephritis is one of the most common causes of childhood acute renal failures which originate from kidneys. Sixteen-year old male patient with the history of isotretinoin use for the last 3 months was admitted with acute renal failure. Renal function parameters were measured as follows: blood urea nitrogen 21 mg/dL, serum creatinine 1.68 mg/dL, cystatin C 1.15 mg/L, and estimated glomerular filtration rate based on cystatin C 56.5 mL/min/1.73 m2. The patient whom pathological signs of renal biopsy sections revealed interstitial mononuclear cell and eosinophilic infiltration was diagnosed with acute tubulointerstitial nephritis.

Conclusion: Isotretinoin is a vitamin A-derived agent which is commonly used in the treatment of acne and may cause drug-related acute tubulointerstitial nephritis.

What is Known:

•Drug-related acute tubulointerstitial nephritis (ATIN) is one of the most common causes of childhood acute renal failures.

What is New:

•Isotretinoin may cause drug-related acute tubulointerstitial nephritis.

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Sarifakioglu E, Yilmaz AE, Erpolat S (2012) Terminal hematuria associated with oral isotretinoin treatment in a patient with acne vulgaris. Pediatr Dermatol 29:668–669CrossRefPubMed

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Title: Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin
Authors: Gulsah Kaya Aksoy
Mustafa Koyun
Bahar Akkaya
Elif Comak
Atilla Gemici
Sema Akman
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 12/2016
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-016-2778-7

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Springer Medicine

Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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