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European Journal of Pediatrics
Published in: European Journal of Pediatrics 6/2016

01-06-2016 | Case Report

Atypical presentation of multicentric Castleman disease in a pediatric patient: pleural and pericardial effusion

Authors: Alkim Oden Akman, Ozge Basaran, Derya Ozyoruk, Unsal Han, Tulin Sayli, Nilgun Cakar

Published in: European Journal of Pediatrics | Issue 6/2016

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Abstract

Castleman disease (CD) is a rare poorly understood lymphoproliferative disorder. Pediatric onset CD has been reported before. However, most of them have benign unicentric pattern. Multicentric CD (MCD) is quite rare in children. Herein, we report a 13-year-old adolescent boy with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation.
Conclusion: MCD should be considered in the differential diagnosis of pleural and/or pericardial effusion with unexplained lymph nodes in children.
What is Known
•Pediatric Castleman disease (CD) most commonly occurs in the unicentric form, which typically is asymptomatic and cured by lymph node excision.
•The diagnosis of MCD can be difficult owing to the heterogeneity of presentation and potential for nonspecific multisystem involvement.
What is New
•A 13-year-old adolescent boy was diagnosed with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation.
•In a pediatric patient with fever, pleural-pericardial effusion and multiple lymph nodes, MCD should be considered in differantial diagnosis.
Literature
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Metadata
Title
Atypical presentation of multicentric Castleman disease in a pediatric patient: pleural and pericardial effusion
Authors
Alkim Oden Akman
Ozge Basaran
Derya Ozyoruk
Unsal Han
Tulin Sayli
Nilgun Cakar
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 6/2016
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-015-2674-6

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