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01-01-2016 | Original Article

Epidemiology of multiple sclerosis in the pediatric population of Sardinia, Italy

Authors: Silvia Dell’Avvento, Maria Alessandra Sotgiu, Salvatorica Manca, Giovanni Sotgiu, Stefano Sotgiu

Published in: European Journal of Pediatrics | Issue 1/2016

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Several authors report MS affecting not only young adults but also children and adolescents. Sardinia is one of the regions at the highest risk for MS worldwide in the adult population; to date, no definite data exist on the pediatric population. The aim of this study was to estimate the incidence and prevalence of pediatric MS (pMS) in northern Sardinia. Patients with diagnosis of optic neuritis, myelitis, acute disseminated encephalomyelitis (ADEM), demyelinating disorders, MS, or clinically isolated syndrome (CIS) according to McDonald criteria were enrolled, when disease onset occurred within the range of 0–18 years. From January 1, 2001 to December 31, 2012, 21 cases of pMS and 5 cases of CIS were found in northern Sardinia. The annual mean pMS incidence was 2.85 cases per 100,000 pediatric population, and the annual mean CIS incidence was 0.68 cases per 100,000 pediatric population. The pMS and CIS prevalence computed on 31 December 2012 was 26.92 and 6.41 per 100,000 pediatric population, respectively.

Conclusion: Our pMS data among Sardinians corroborate the epidemiological scenario described in the adult population being the incidence estimates significantly higher than those reported elsewhere.

What is Known:

• Sardinia is one of the regions at the highest risk for MS worldwide in the adult population.

• To date, no definite data exist on the pediatric population.

What is New:

• The pediatric MS incidence in Sardinia is estimated to be significantly higher than those reported elsewhere.

• The pediatric MS prevalence in Sardinia is among the highest values worldwide.

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Title: Epidemiology of multiple sclerosis in the pediatric population of Sardinia, Italy
Authors: Silvia Dell’Avvento
Maria Alessandra Sotgiu
Salvatorica Manca
Giovanni Sotgiu
Stefano Sotgiu
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 1/2016
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-015-2588-3

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Epidemiology of multiple sclerosis in the pediatric population of Sardinia, Italy

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