01-12-2015 | Original Article
High-resolution manometry combined with impedance measurements discriminates the cause of dysphagia in children
Published in: European Journal of Pediatrics | Issue 12/2015
Login to get accessAbstract
What is Known:
• Pressure-flow analysis (PFA) can detect abnormalities in esophageal motility using integrated analysis of bolus propulsion and bolus flow during swallowing. • AIM analysis has recently been reported to be useful in identifying subtle pre-operative esophageal dysfunction in adult patients who developed post-fundoplication dysphagia as well as in patients with non-obstructive dysphagia. |
What is New:
• Pressure-flow parameters can distinguish the cause of dysphagia in paediatric patients.
• Combined high-resolution manometry and impedance measurements with pressure-flow analysis can differentiate paediatric patients with dysphagia symptoms in relation to either weak peristalsis (poor bolus clearance) or over-pressurization (abnormal bolus flow resistance).
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How might it impact on clinical practice in the future?
• This study supports the use of a novel objective analysis method on recordings that are readily used in paediatric clinical practice.
• The pressure-flow approach allows discriminating esophageal dysfunction in relation to dysphagia symptoms in children. This has not been achieved in children with current analysis methods.
• The new findings of this study allow a dichotomous categorization of esophageal function, which may help to guide the selection of the most optimal treatment such as pharmacological or endoscopic therapy.
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