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European Journal of Pediatrics
Published in: European Journal of Pediatrics 6/2015

01-06-2015 | Original Article

Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis: a case–control study from a tertiary care center in Turkey

Authors: Mehmet Nevzat Cizmeci, Mehmet Kenan Kanburoglu, Ahmet Zulfikar Akelma, Abdullah Ayyildiz, Irem Kutukoglu, Dilara Dilsad Malli, Mustafa Mansur Tatli

Published in: European Journal of Pediatrics | Issue 6/2015

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Abstract

Vitamin D has been linked with immunity, and the immunomodulatory role of this molecule in regulating key elements of the immune system has become an area of intense scientific investigation. We designed a case–control study to investigate whether neonates with early-onset neonatal sepsis (EONS) had lower levels of vitamin D. The primary exposure for the analysis in the study was the cord-blood level of 25-hydroxyvitamin D (25(OH)D). Of the 2571 live births occurring during the 18-month study period, 53 infants were admitted to the neonatal intensive care unit with suspected EONS. After clinical and laboratory confirmation, 40 newborns with EONS and 43 controls were analyzed. Cord-blood 25(OH)D levels of infants in the study group were significantly lower than that of the control group (median 12.6 ng/mL (3.1–78.9) vs. 21 (5–118); p = 0.038, respectively). In multivariate models, a low cord-blood 25(OH)D level (<30 ng/ml) was associated with an increased risk of EONS (OR = 5.6; 95 % CI = 1.3–23.5).
Conclusion: Cord-blood 25(OH)D levels of neonates with EONS were significantly lower than that of the healthy controls, and a low level of cord-blood vitamin D was found to be associated with an increased risk of EONS. Further studies are warranted to confirm this association.
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Metadata
Title
Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis: a case–control study from a tertiary care center in Turkey
Authors
Mehmet Nevzat Cizmeci
Mehmet Kenan Kanburoglu
Ahmet Zulfikar Akelma
Abdullah Ayyildiz
Irem Kutukoglu
Dilara Dilsad Malli
Mustafa Mansur Tatli
Publication date
01-06-2015
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 6/2015
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-014-2469-1

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