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European Journal of Pediatrics
Published in: European Journal of Pediatrics 6/2015

01-06-2015 | Original Article

Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

Authors: Irene Alberici, Aysun Karabay Bayazit, Dorota Drozdz, Sevinç Emre, Michel Fischbach, Jérôme Harambat, Augustina Jankauskiene, Mieczyslaw Litwin, Sevgi Mir, William Morello, Amira Peco-Antic, Peter Sallay, Lale Sever, Giacomo D. Simonetti, Przemyslaw Szczesniak, Ana Teixeira, Enrico Vidal, Elke Wuehl, Otto Mehls, Lutz T. Weber, Franz Schaefer, Giovanni Montini, for the ESCAPE study group and the PREDICT trial

Published in: European Journal of Pediatrics | Issue 6/2015

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Abstract

Knowledge of the distribution spectrum of causative organisms and their resistance patterns has become a core requirement for the rational and effective management of urinary tract infections. In the context of a prospective trial on the use of antibiotic prophylaxis in infants with underling kidney malformations, we conducted an online survey among paediatric nephrologists on positive urine cultures (July 2010–June 2012) from both hospitalized and non-hospitalized infants under 24 months of age. We collected 4745 urine cultures (UCs) at 18 units in 10 European countries. Escherichia coli was the most frequent bacterium isolated from UCs; however, in 10/16 hospitals and in 6/15 community settings, E. coli was isolated in less than 50 % of the total positive UCs. Other bacterial strains were Klebsiella, Enterococcus, Proteus and Pseudomonas not only from hospital settings. E. coli showed a high resistance to amoxicillin and trimethoprim and variable to cephalosporin. Nitrofurantoin had a good rate of efficacy, with 11/16 hospitals and 11/14 community settings reporting a resistance lower than 5 %.
Conclusion: E. coli is the most common organism causing UTIs in infants; however, other bacterial strains are frequently isolated. As a result, antibiotic prophylaxis should be more elastic and adaptable over time in order to guarantee maximum efficacy.
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Metadata
Title
Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group
Authors
Irene Alberici
Aysun Karabay Bayazit
Dorota Drozdz
Sevinç Emre
Michel Fischbach
Jérôme Harambat
Augustina Jankauskiene
Mieczyslaw Litwin
Sevgi Mir
William Morello
Amira Peco-Antic
Peter Sallay
Lale Sever
Giacomo D. Simonetti
Przemyslaw Szczesniak
Ana Teixeira
Enrico Vidal
Elke Wuehl
Otto Mehls
Lutz T. Weber
Franz Schaefer
Giovanni Montini
for the ESCAPE study group and the PREDICT trial
Publication date
01-06-2015
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 6/2015
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-014-2459-3

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