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Published in: European Journal of Pediatrics 2/2015

Open Access 01-02-2015 | Review

Cow’s milk allergy: evidence-based diagnosis and management for the practitioner

Authors: Carlos Lifschitz, Hania Szajewska

Published in: European Journal of Pediatrics | Issue 2/2015

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Abstract

This review summarizes current evidence and recommendations regarding cow’s milk allergy (CMA), the most common food allergy in young children, for the primary and secondary care providers. The diagnostic approach includes performing a medical history, physical examination, diagnostic elimination diets, skin prick tests, specific IgE measurements, and oral food challenges. Strict avoidance of the offending allergen is the only therapeutic option. Oral immunotherapy is being studied, but it is not yet recommended for routine clinical practice. For primary prevention of allergy, exclusive breastfeeding for at least 4 months and up to 6 months is desirable. Infants with a documented hereditary risk of allergy (i.e., an affected parent and/or sibling) who cannot be breastfed exclusively should receive a formula with confirmed reduced allergenicity, i.e., a partially or extensively hydrolyzed formula, as a means of preventing allergic reactions, primarily atopic dermatitis. Avoidance or delayed introduction of solid foods beyond 4–6 months for allergy prevention is not recommended.
Conclusion: For all of those involved in taking care of children’s health, it is important to understand the multifaceted aspects of CMA, such as its epidemiology, presentation, diagnosis, and dietary management, as well as its primary prevention.
Literature
1.
go back to reference Ahrens B, Lopes de Oliveira LC, Grabenhenrich L, Schulz G, Niggemann B, Wahn U, Beyer K (2012) Individual cow’s milk allergens as prognostic markers for tolerance development? Clin Exp Allergy 42:1630–1637PubMedCrossRef Ahrens B, Lopes de Oliveira LC, Grabenhenrich L, Schulz G, Niggemann B, Wahn U, Beyer K (2012) Individual cow’s milk allergens as prognostic markers for tolerance development? Clin Exp Allergy 42:1630–1637PubMedCrossRef
2.
go back to reference Anandan C, Nurmatov U, Sheikh A (2009) Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis. Allergy 64:840–848PubMedCrossRef Anandan C, Nurmatov U, Sheikh A (2009) Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis. Allergy 64:840–848PubMedCrossRef
3.
go back to reference Berni Canani R, Nocerino R, Terrin G, Coruzzo A, Cosenza L, Leone L, Troncone R (2012) Effect of Lactobacillus GG on tolerance acquisition in infants with cow’s milk allergy: a randomized trial. J Allergy Clin Immunol 129:580–582PubMedCrossRef Berni Canani R, Nocerino R, Terrin G, Coruzzo A, Cosenza L, Leone L, Troncone R (2012) Effect of Lactobacillus GG on tolerance acquisition in infants with cow’s milk allergy: a randomized trial. J Allergy Clin Immunol 129:580–582PubMedCrossRef
4.
go back to reference Berni CR, Nocerino R, Terrin G, Frediani T, Lucarelli S, Cosenza L, Passariello A, Leone L, Granata V, Di Costanzo M, Pezzella V, Troncone R (2013) Formula selection for management of children with cow’s milk allergy influences the rate of acquisition of tolerance: a prospective multicenter study. J Pediatr 163:771–777CrossRef Berni CR, Nocerino R, Terrin G, Frediani T, Lucarelli S, Cosenza L, Passariello A, Leone L, Granata V, Di Costanzo M, Pezzella V, Troncone R (2013) Formula selection for management of children with cow’s milk allergy influences the rate of acquisition of tolerance: a prospective multicenter study. J Pediatr 163:771–777CrossRef
5.
go back to reference Betsi GI, Papadavid E, Falagas ME (2008) Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol 9:93–103PubMedCrossRef Betsi GI, Papadavid E, Falagas ME (2008) Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol 9:93–103PubMedCrossRef
6.
go back to reference Bhatia J, Greer F, American Academy of Pediatrics Committee on Nutrition (2008) Use of soy protein-based formulas in infant feeding. Pediatrics 121:1062–1068PubMedCrossRef Bhatia J, Greer F, American Academy of Pediatrics Committee on Nutrition (2008) Use of soy protein-based formulas in infant feeding. Pediatrics 121:1062–1068PubMedCrossRef
7.
go back to reference Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA et al (2010) Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 126:S1–S58PubMedCentralPubMedCrossRef Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA et al (2010) Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 126:S1–S58PubMedCentralPubMedCrossRef
8.
go back to reference Brożek JL, Terracciano L, Hsu J, Kreis J, Compalati E, Santesso N, Fiocchi A, Schünemann HJ (2012) Oral immunotherapy for IgE-mediated cow’s milk allergy: a systematic review and meta-analysis. Clin Exp Allergy 42:363–374PubMedCrossRef Brożek JL, Terracciano L, Hsu J, Kreis J, Compalati E, Santesso N, Fiocchi A, Schünemann HJ (2012) Oral immunotherapy for IgE-mediated cow’s milk allergy: a systematic review and meta-analysis. Clin Exp Allergy 42:363–374PubMedCrossRef
9.
go back to reference Burks AW, Tang M, Sicherer S, Muraro A, Eigenmann PA, Ebisawa M et al (2012) ICON: food allergy. J Allergy Clin Immunol 129:906–920PubMedCrossRef Burks AW, Tang M, Sicherer S, Muraro A, Eigenmann PA, Ebisawa M et al (2012) ICON: food allergy. J Allergy Clin Immunol 129:906–920PubMedCrossRef
10.
go back to reference Chafen JJ, Newberry SJ, Riedl MA, Bravata DM, Maglione M, Suttorp MJ, Sundaram V, Paige NM, Towfigh A, Hulley BJ, Shekelle PG (2010) Diagnosing and managing common food allergies: a systematic review. JAMA 303:1848–1856PubMedCrossRef Chafen JJ, Newberry SJ, Riedl MA, Bravata DM, Maglione M, Suttorp MJ, Sundaram V, Paige NM, Towfigh A, Hulley BJ, Shekelle PG (2010) Diagnosing and managing common food allergies: a systematic review. JAMA 303:1848–1856PubMedCrossRef
11.
go back to reference D’Vaz N, Meldrum SJ, Dunstan JA, Martino D, McCarthy S, Metcalfe J et al (2012) Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. Pediatrics 130:674–682PubMedCrossRef D’Vaz N, Meldrum SJ, Dunstan JA, Martino D, McCarthy S, Metcalfe J et al (2012) Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. Pediatrics 130:674–682PubMedCrossRef
12.
go back to reference Dhami S, Panesar SS, Roberts G, Muraro A, Worm M, Bilò MB, Cardona V, Dubois AE, DunnGalvin A, Eigenmann P, Fernandez-Rivas M, Halken S, Lack G, Niggemann B, Rueff F, Santos AF, Vlieg-Boerstra B, Zolkipli ZQ, Sheikh A, EAACI Food Allergy and Anaphylaxis Guidelines Group (2014) Management of anaphylaxis: a systematic review. Allergy 69:168–175PubMedCrossRef Dhami S, Panesar SS, Roberts G, Muraro A, Worm M, Bilò MB, Cardona V, Dubois AE, DunnGalvin A, Eigenmann P, Fernandez-Rivas M, Halken S, Lack G, Niggemann B, Rueff F, Santos AF, Vlieg-Boerstra B, Zolkipli ZQ, Sheikh A, EAACI Food Allergy and Anaphylaxis Guidelines Group (2014) Management of anaphylaxis: a systematic review. Allergy 69:168–175PubMedCrossRef
13.
go back to reference Domínguez-Ortega G, Borrelli O, Meyer R, Dziubak R, De Koker C, Godwin H, Fleming C, Thapar N, Elawad M, Kiparissi F, Fox AT, Shah N (2014) Extraintestinal manifestations in children with gastrointestinal food allergy. J Pediatr Gastroenterol Nutr 59(2):210–214 Domínguez-Ortega G, Borrelli O, Meyer R, Dziubak R, De Koker C, Godwin H, Fleming C, Thapar N, Elawad M, Kiparissi F, Fox AT, Shah N (2014) Extraintestinal manifestations in children with gastrointestinal food allergy. J Pediatr Gastroenterol Nutr 59(2):210–214
14.
go back to reference ESPGHAN Committee on Nutrition, Agostoni C, Axelsson I, Goulet O, Koletzko B, Michaelsen KF, Puntis J, Rieu D, Rigo J, Shamir R, Szajewska H, Turck D (2006) Soy protein infant formulae and follow-on formulae: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 42:352–361PubMedCrossRef ESPGHAN Committee on Nutrition, Agostoni C, Axelsson I, Goulet O, Koletzko B, Michaelsen KF, Puntis J, Rieu D, Rigo J, Shamir R, Szajewska H, Turck D (2006) Soy protein infant formulae and follow-on formulae: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 42:352–361PubMedCrossRef
15.
go back to reference ESPGHAN Committee on Nutrition, Agostoni C, Braegger C, Decsi T, Kolacek S, Koletzko B, Michaelsen KF, Mihatsch W, Moreno LA, Puntis J, Shamir R, Szajewska H, Turck D, van Goudoever J (2009) Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 49:112–125PubMedCrossRef ESPGHAN Committee on Nutrition, Agostoni C, Braegger C, Decsi T, Kolacek S, Koletzko B, Michaelsen KF, Mihatsch W, Moreno LA, Puntis J, Shamir R, Szajewska H, Turck D, van Goudoever J (2009) Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 49:112–125PubMedCrossRef
16.
go back to reference ESPGHAN Committee on Nutrition, Agostoni C, Decsi T, Fewtrell M, Goulet O, Kolacek S et al (2008) Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 46:99–110PubMedCrossRef ESPGHAN Committee on Nutrition, Agostoni C, Decsi T, Fewtrell M, Goulet O, Kolacek S et al (2008) Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 46:99–110PubMedCrossRef
17.
go back to reference Filipiak B, Zutavern A, Koletzko S, von Berg A, Brockow I, Grubl A, Berdel D, Reinhardt D, Bauer CP, Wichmann HE, Heinrich J, GINI-Group (2007) Solid food introduction in relation to eczema: results from a four-year prospective birth cohort study. J Pediatr 151:352–358PubMedCrossRef Filipiak B, Zutavern A, Koletzko S, von Berg A, Brockow I, Grubl A, Berdel D, Reinhardt D, Bauer CP, Wichmann HE, Heinrich J, GINI-Group (2007) Solid food introduction in relation to eczema: results from a four-year prospective birth cohort study. J Pediatr 151:352–358PubMedCrossRef
18.
go back to reference Fiocchi A, Brozek J, Schünemann H, Bahna SL, von Berg A, Beyer K, Bozzola M, Bradsher J, Compalati E, Ebisawa M, Guzmán MA, Li H, Heine RG, Keith P, Lack G, Landi M, Martelli A, Rancé F, Sampson H, Stein A, Terracciano L, Vieths S (2010) World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) guidelines. World Allergy Organ J 3:57–161PubMedCentralPubMedCrossRef Fiocchi A, Brozek J, Schünemann H, Bahna SL, von Berg A, Beyer K, Bozzola M, Bradsher J, Compalati E, Ebisawa M, Guzmán MA, Li H, Heine RG, Keith P, Lack G, Landi M, Martelli A, Rancé F, Sampson H, Stein A, Terracciano L, Vieths S (2010) World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) guidelines. World Allergy Organ J 3:57–161PubMedCentralPubMedCrossRef
19.
go back to reference Fiocchi A, Burks W, Bahna SL, Bielory L, Boyle RJ, Cocco R, Dreborg S, Goodman R, Kuitunen M, Haahtela T, Heine RG, Lack G, Osborn DA, Sampson H, Tannock GW, Lee BW, On behalf of the WAO Special Committee on Food Allergy and Nutrition (2012) Clinical Use of Probiotics in Pediatric Allergy (CUPPA): a World Allergy Organization position paper. World Allergy Organ J 5:148–167PubMedCentralPubMedCrossRef Fiocchi A, Burks W, Bahna SL, Bielory L, Boyle RJ, Cocco R, Dreborg S, Goodman R, Kuitunen M, Haahtela T, Heine RG, Lack G, Osborn DA, Sampson H, Tannock GW, Lee BW, On behalf of the WAO Special Committee on Food Allergy and Nutrition (2012) Clinical Use of Probiotics in Pediatric Allergy (CUPPA): a World Allergy Organization position paper. World Allergy Organ J 5:148–167PubMedCentralPubMedCrossRef
20.
go back to reference Fleischer DM, Spergel JM, Assa’ad AH, Pongracic JA (2013) Primary prevention of allergic disease through nutritional interventions. J Allergy Clin Immunol Pract 1:29–36PubMedCrossRef Fleischer DM, Spergel JM, Assa’ad AH, Pongracic JA (2013) Primary prevention of allergic disease through nutritional interventions. J Allergy Clin Immunol Pract 1:29–36PubMedCrossRef
21.
go back to reference Greer FR, Sicherer SH, Burks AW, American Academy of Pediatrics Committee on Nutrition, American Academy of Pediatrics Section on Allergy and Immunology (2008) Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 121:183–191PubMedCrossRef Greer FR, Sicherer SH, Burks AW, American Academy of Pediatrics Committee on Nutrition, American Academy of Pediatrics Section on Allergy and Immunology (2008) Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 121:183–191PubMedCrossRef
22.
go back to reference Grüber C, van Stuijvenberg M, Mosca F, Moro G, Chirico G, Braegger CP, Riedler J, Boehm G, Wahn U, MIPS 1 Working Group (2010) Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants. J Allergy Clin Immunol 126:791–797PubMedCrossRef Grüber C, van Stuijvenberg M, Mosca F, Moro G, Chirico G, Braegger CP, Riedler J, Boehm G, Wahn U, MIPS 1 Working Group (2010) Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants. J Allergy Clin Immunol 126:791–797PubMedCrossRef
23.
go back to reference Hodge L, Salome CM, Peat JK, Haby MM, Xuan W, Woolcock AJ (1996) Consumption of oily fish and childhood asthma risk. Med J Aust 164:137–140PubMed Hodge L, Salome CM, Peat JK, Haby MM, Xuan W, Woolcock AJ (1996) Consumption of oily fish and childhood asthma risk. Med J Aust 164:137–140PubMed
24.
go back to reference Hol J, van Leer EH, Elink Schuurman BE, de Ruiter LF, Samsom JN, Hop W et al (2008) The acquisition of tolerance toward cow’s milk through probiotic supplementation: a randomized, controlled trial. J Allergy Clin Immunol 121:1448–1454PubMedCrossRef Hol J, van Leer EH, Elink Schuurman BE, de Ruiter LF, Samsom JN, Hop W et al (2008) The acquisition of tolerance toward cow’s milk through probiotic supplementation: a randomized, controlled trial. J Allergy Clin Immunol 121:1448–1454PubMedCrossRef
25.
go back to reference Høst A (2002) Frequency of cow’s milk allergy in childhood. Ann Allergy Asthma Immunol 89(6 Suppl 1):33–37PubMedCrossRef Høst A (2002) Frequency of cow’s milk allergy in childhood. Ann Allergy Asthma Immunol 89(6 Suppl 1):33–37PubMedCrossRef
26.
go back to reference Isolauri E, Sütas Y, Salo MK, Isosomppi R, Kaila M (1998) Elimination diet in cow’s milk allergy: risk for impaired growth in young children. J Pediatr 132:1004–1009PubMedCrossRef Isolauri E, Sütas Y, Salo MK, Isosomppi R, Kaila M (1998) Elimination diet in cow’s milk allergy: risk for impaired growth in young children. J Pediatr 132:1004–1009PubMedCrossRef
27.
go back to reference Järvinen KM, Sicherer SH, Sampson HA, Nowak-Wegrzyn A (2008) Use of multiple doses of epinephrine in food-induced anaphylaxis in children. J Allergy Clin Immunol 122:133–138PubMedCrossRef Järvinen KM, Sicherer SH, Sampson HA, Nowak-Wegrzyn A (2008) Use of multiple doses of epinephrine in food-induced anaphylaxis in children. J Allergy Clin Immunol 122:133–138PubMedCrossRef
28.
go back to reference Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, Motala C, Ortega Martell JA, Platts-Mills TA, Ring J, Thien F, Van Cauwenberge P, Williams HC (2004) Revised nomenclature for allergy for global use: report of the nomenclature review Committee of the World Allergy Organization. J Allergy Clin Immunol 113:832–836PubMedCrossRef Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, Motala C, Ortega Martell JA, Platts-Mills TA, Ring J, Thien F, Van Cauwenberge P, Williams HC (2004) Revised nomenclature for allergy for global use: report of the nomenclature review Committee of the World Allergy Organization. J Allergy Clin Immunol 113:832–836PubMedCrossRef
29.
go back to reference Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, van Hage-Hamsten M, Wüthrich B (2001) A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 56:813–824PubMedCrossRef Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, van Hage-Hamsten M, Wüthrich B (2001) A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 56:813–824PubMedCrossRef
30.
go back to reference Kim JS, Nowak-Węgrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA (2011) Dietary baked milk accelerates the resolution of cow’s milk allergy in children. J Allergy Clin Immunol 128:125–131.e2PubMedCentralPubMedCrossRef Kim JS, Nowak-Węgrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA (2011) Dietary baked milk accelerates the resolution of cow’s milk allergy in children. J Allergy Clin Immunol 128:125–131.e2PubMedCentralPubMedCrossRef
31.
go back to reference Koletzko S, Niggemann B, Arato A, Dias JA, Heuschkel R, Husby S, Mearin ML, Papadopoulou A, Ruemmele FM, Staiano A, Schäppi MG, Vandenplas Y (2012) European Society of Pediatric Gastroenterology, Hepatology, and Nutrition. Diagnostic approach and management of cow’s-milk protein allergy in infants and children: ESPGHAN GI Committee practical guidelines. J Pediatr Gastroenterol Nutr 55:221–229PubMedCrossRef Koletzko S, Niggemann B, Arato A, Dias JA, Heuschkel R, Husby S, Mearin ML, Papadopoulou A, Ruemmele FM, Staiano A, Schäppi MG, Vandenplas Y (2012) European Society of Pediatric Gastroenterology, Hepatology, and Nutrition. Diagnostic approach and management of cow’s-milk protein allergy in infants and children: ESPGHAN GI Committee practical guidelines. J Pediatr Gastroenterol Nutr 55:221–229PubMedCrossRef
32.
go back to reference Koplin JJ, Osborne NJ, Wake M, Martin PE, Gurrin LC, Robinson MN, Tey D, Slaa M, Thiele L, Miles L, Anderson D, Tan T, Dang TD, Hill DJ, Lowe AJ, Matheson MC, Ponsonby AL, Tang ML, Dharmage SC, Allen KJ (2010) Can early introduction of egg prevent egg allergy in infants? A population-based study. J Allergy Clin Immunol 126:807–813PubMedCrossRef Koplin JJ, Osborne NJ, Wake M, Martin PE, Gurrin LC, Robinson MN, Tey D, Slaa M, Thiele L, Miles L, Anderson D, Tan T, Dang TD, Hill DJ, Lowe AJ, Matheson MC, Ponsonby AL, Tang ML, Dharmage SC, Allen KJ (2010) Can early introduction of egg prevent egg allergy in infants? A population-based study. J Allergy Clin Immunol 126:807–813PubMedCrossRef
33.
go back to reference Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M (2007) Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 119:192–198PubMedCrossRef Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M (2007) Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 119:192–198PubMedCrossRef
34.
go back to reference Lee J, Seto D, Bielory L (2008) Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. J Allergy Clin Immunol 121:116–121PubMedCrossRef Lee J, Seto D, Bielory L (2008) Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. J Allergy Clin Immunol 121:116–121PubMedCrossRef
35.
go back to reference Lemon-Mulé H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A (2008) Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 122:977–983.e1PubMedCrossRef Lemon-Mulé H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A (2008) Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 122:977–983.e1PubMedCrossRef
36.
go back to reference Luyt D, Ball H, Makwana N, Green MR, Bravin K, Nasser SM, Clark AT (2014) BSACI guideline for the diagnosis and management of cow’s milk allergy. Clin Exp Allergy 44:642–672PubMedCrossRef Luyt D, Ball H, Makwana N, Green MR, Bravin K, Nasser SM, Clark AT (2014) BSACI guideline for the diagnosis and management of cow’s milk allergy. Clin Exp Allergy 44:642–672PubMedCrossRef
37.
go back to reference Maslova E, Granstrom C, Hansen S, Petersen SB, Strom M, Willett WC, Olsen SF (2012) Peanut and tree nut consumption during pregnancy and allergic disease in children—should mothers decrease their intake? Longitudinal evidence from the Danish National Birth Cohort. J Allergy Clin Immunol 130:724–732PubMedCrossRef Maslova E, Granstrom C, Hansen S, Petersen SB, Strom M, Willett WC, Olsen SF (2012) Peanut and tree nut consumption during pregnancy and allergic disease in children—should mothers decrease their intake? Longitudinal evidence from the Danish National Birth Cohort. J Allergy Clin Immunol 130:724–732PubMedCrossRef
38.
go back to reference Mehta H, Groetch M, Wang J (2013) Growth and nutritional concerns in children with food allergy. Curr Opin Allergy Clin Immunol 13:275–279PubMedCentralPubMed Mehta H, Groetch M, Wang J (2013) Growth and nutritional concerns in children with food allergy. Curr Opin Allergy Clin Immunol 13:275–279PubMedCentralPubMed
39.
go back to reference Mihrshahi S, Peat JK, Webb K, Tovey ER, Marks GB, Mellis CM, Leeder SR (2001) The childhood asthma prevention study (CAPS): design and research protocol of a randomized trial for the primary prevention of asthma. Control Clin Trials 22:333–354PubMedCrossRef Mihrshahi S, Peat JK, Webb K, Tovey ER, Marks GB, Mellis CM, Leeder SR (2001) The childhood asthma prevention study (CAPS): design and research protocol of a randomized trial for the primary prevention of asthma. Control Clin Trials 22:333–354PubMedCrossRef
40.
go back to reference Nowak-Wegrzyn A, Assa’ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS (2009) Work Group report: oral food challenge testing. J Allergy Clin Immunol 123:S365–S383PubMedCrossRef Nowak-Wegrzyn A, Assa’ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS (2009) Work Group report: oral food challenge testing. J Allergy Clin Immunol 123:S365–S383PubMedCrossRef
41.
go back to reference Nurmatov U, Devereux G, Sheikh A (2011) Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J Allergy Clin Immunol 127:724–733.e1-30PubMedCrossRef Nurmatov U, Devereux G, Sheikh A (2011) Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J Allergy Clin Immunol 127:724–733.e1-30PubMedCrossRef
42.
go back to reference Oddy WH, de Klerk NH, Kendall GE, Mihrshahi S, Peat JK (2004) Ratio of omega-6 to omega-3 fatty acids and childhood asthma. J Asthma 41:319–326PubMedCrossRef Oddy WH, de Klerk NH, Kendall GE, Mihrshahi S, Peat JK (2004) Ratio of omega-6 to omega-3 fatty acids and childhood asthma. J Asthma 41:319–326PubMedCrossRef
43.
go back to reference Osborn DA, Sinn J (2006) Soy formula for prevention of allergy and food intolerance in infants. Cochrane Database Syst Rev (4):CD003741 Osborn DA, Sinn J (2006) Soy formula for prevention of allergy and food intolerance in infants. Cochrane Database Syst Rev (4):CD003741
44.
go back to reference Osborn DA, Sinn JK (2007) Prebiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev 4, CD006474PubMed Osborn DA, Sinn JK (2007) Prebiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev 4, CD006474PubMed
45.
go back to reference Osborn DA, Sinn JK (2007) Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database of Syst Rev (4) Art. No.: CD006475 Osborn DA, Sinn JK (2007) Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database of Syst Rev (4) Art. No.: CD006475
46.
go back to reference Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, Makrides M (2012) Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. Br Med J 344:e184CrossRef Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, Makrides M (2012) Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. Br Med J 344:e184CrossRef
47.
go back to reference Ravelli AM, Tobanelli P, Volpi S, Ugazio AG (2001) Vomiting and gastric motility in infants with cow’s milk allergy. J Pediatr Gastroenterol Nutr 32:59–64PubMedCrossRef Ravelli AM, Tobanelli P, Volpi S, Ugazio AG (2001) Vomiting and gastric motility in infants with cow’s milk allergy. J Pediatr Gastroenterol Nutr 32:59–64PubMedCrossRef
48.
go back to reference Rothenberg ME (2004) Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 113:11–29PubMedCrossRef Rothenberg ME (2004) Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 113:11–29PubMedCrossRef
49.
go back to reference Sampson HA, Gerth van Wijk R, Bindslev-Jensen C, Sicherer S, Teuber SS, Burks AW, Dubois AE, Beyer K, Eigenmann PA, Spergel JM, Werfel T, Chinchilli VM (2012) Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report. J Allergy Clin Immunol 130:1260–1274PubMedCrossRef Sampson HA, Gerth van Wijk R, Bindslev-Jensen C, Sicherer S, Teuber SS, Burks AW, Dubois AE, Beyer K, Eigenmann PA, Spergel JM, Werfel T, Chinchilli VM (2012) Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report. J Allergy Clin Immunol 130:1260–1274PubMedCrossRef
50.
go back to reference Sampson HA (2001) Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 107:891–896PubMedCrossRef Sampson HA (2001) Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 107:891–896PubMedCrossRef
51.
go back to reference Santos A, Dias A, Pinheiro JA (2010) Predictive factors for the persistence of cow’s milk allergy. Pediatr Allergy Immunol 21:1127–1134PubMedCrossRef Santos A, Dias A, Pinheiro JA (2010) Predictive factors for the persistence of cow’s milk allergy. Pediatr Allergy Immunol 21:1127–1134PubMedCrossRef
52.
go back to reference Section on Breastfeeding (2012) Breastfeeding and the use of human milk. Pediatrics 129:e827–e841CrossRef Section on Breastfeeding (2012) Breastfeeding and the use of human milk. Pediatrics 129:e827–e841CrossRef
53.
go back to reference Sicherer SH, Sampson HA (2014) Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol 133:291–307PubMedCrossRef Sicherer SH, Sampson HA (2014) Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol 133:291–307PubMedCrossRef
54.
go back to reference Sicherer SH, Teuber S, Adverse Reactions to Foods Committee (2014) Current approach to the diagnosis and management of adverse reactions to foods. J Allergy Clin Immunol 114:1146–1150CrossRef Sicherer SH, Teuber S, Adverse Reactions to Foods Committee (2014) Current approach to the diagnosis and management of adverse reactions to foods. J Allergy Clin Immunol 114:1146–1150CrossRef
55.
go back to reference Sicherer SH, Wood RA, Stablein D, Lindblad R, Burks AW, Liu AH, Jones SM, Fleischer DM, Leung DY, Sampson HA (2010) Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants. J Allergy Clin Immunol 126:1191–1197PubMedCentralPubMedCrossRef Sicherer SH, Wood RA, Stablein D, Lindblad R, Burks AW, Liu AH, Jones SM, Fleischer DM, Leung DY, Sampson HA (2010) Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants. J Allergy Clin Immunol 126:1191–1197PubMedCentralPubMedCrossRef
57.
go back to reference Snijders BE, Thijs C, van Ree R, van den Brandt PA (2008) Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics 122:e115–e122PubMedCrossRef Snijders BE, Thijs C, van Ree R, van den Brandt PA (2008) Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics 122:e115–e122PubMedCrossRef
58.
go back to reference Soares-Weiser K, Takwoingi Y, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Halken S, Poulsen L, van Ree R, Vlieg-Boerstra BJ, Sheikh A, EAACI Food Allergy and Anaphylaxis Guidelines Group (2014) The diagnosis of food allergy: a systematic review and meta-analysis. Allergy 69:76–86PubMedCrossRef Soares-Weiser K, Takwoingi Y, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Halken S, Poulsen L, van Ree R, Vlieg-Boerstra BJ, Sheikh A, EAACI Food Allergy and Anaphylaxis Guidelines Group (2014) The diagnosis of food allergy: a systematic review and meta-analysis. Allergy 69:76–86PubMedCrossRef
59.
go back to reference Tromp II, Kiefte-de Jong JC, Lebon A, Renders CM, Jaddoe VW, Hofman A, de Jongste JC, Moll HA (2011) The introduction of allergenic foods and the development of reported wheezing and eczema in childhood: the Generation R study. Arch Pediatr Adolesc Med 165:933–938PubMedCrossRef Tromp II, Kiefte-de Jong JC, Lebon A, Renders CM, Jaddoe VW, Hofman A, de Jongste JC, Moll HA (2011) The introduction of allergenic foods and the development of reported wheezing and eczema in childhood: the Generation R study. Arch Pediatr Adolesc Med 165:933–938PubMedCrossRef
60.
go back to reference Vandenplas Y, Bhatia J, Shamir R, Agostoni C, Turck D, Staiano A, Szajewska H (2014) Hydrolysed formulas for allergy prevention. J Pediatr Gastroenterol Nutr 58:549–552PubMedCrossRef Vandenplas Y, Bhatia J, Shamir R, Agostoni C, Turck D, Staiano A, Szajewska H (2014) Hydrolysed formulas for allergy prevention. J Pediatr Gastroenterol Nutr 58:549–552PubMedCrossRef
61.
62.
go back to reference Wal JM (2004) Bovine milk allergenicity. Ann Allergy Asthma Immunol 93:2–11CrossRef Wal JM (2004) Bovine milk allergenicity. Ann Allergy Asthma Immunol 93:2–11CrossRef
63.
go back to reference Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA (2013) The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol 131:805–812PubMedCentralPubMedCrossRef Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA (2013) The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol 131:805–812PubMedCentralPubMedCrossRef
64.
go back to reference Yeung JP, Kloda LA, McDevitt J, Ben-Shoshan M, Alizadehfar R (2012) Oral immunotherapy for milk allergy. Cochrane Database Syst Rev 11, CD009542PubMed Yeung JP, Kloda LA, McDevitt J, Ben-Shoshan M, Alizadehfar R (2012) Oral immunotherapy for milk allergy. Cochrane Database Syst Rev 11, CD009542PubMed
65.
go back to reference Zutavern A, Brockow I, Schaaf B, von Berg A, Diez U, Borte M, Kraemer U, Herbarth O, Behrendt H, Wichmann HE, Heinrich J, LISA Study Group (2008) Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA. Pediatrics 121:e44–e52PubMed Zutavern A, Brockow I, Schaaf B, von Berg A, Diez U, Borte M, Kraemer U, Herbarth O, Behrendt H, Wichmann HE, Heinrich J, LISA Study Group (2008) Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA. Pediatrics 121:e44–e52PubMed
Metadata
Title
Cow’s milk allergy: evidence-based diagnosis and management for the practitioner
Authors
Carlos Lifschitz
Hania Szajewska
Publication date
01-02-2015
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 2/2015
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-014-2422-3

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