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01-12-2014 | Case Report

Persistent pure red cell aplasia in dicygotic twins with persistent congenital parvovirus B19 infection—remission following high dose intravenous immunoglobulin

Authors: Alice Lejeune, Malte Cremer, Horst von Bernuth, Anke Edelmann, Susanne Modrow, Christoph Bührer

Published in: European Journal of Pediatrics | Issue 12/2014

Abstract

We report the course of dicygotic twins born preterm after 29 ⁴/₇ weeks of gestation due to congenital Parvovirus B19 infection causing fetal hydrops with severe anemia in one infant in whom intrauterine transfusion was impossible to perform and high levels of viremia in both infants. After being discharged, they were readmitted at 3 months of age with critical aplastic crisis. Therapy with intravenous immunoglobulin infusion resulted in decreasing viremia followed by stable hemoglobin levels in both infants.

Conclusion: Intravenous immunoglobulin treatment of congenital pure red cell aplasia due to Parvovirus B19 infection in preterm infants seems to be effective to introduce viral remission and to normalize erythropoiesis.

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Title: Persistent pure red cell aplasia in dicygotic twins with persistent congenital parvovirus B19 infection—remission following high dose intravenous immunoglobulin
Authors: Alice Lejeune
Malte Cremer
Horst von Bernuth
Anke Edelmann
Susanne Modrow
Christoph Bührer
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 12/2014
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-014-2420-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Persistent pure red cell aplasia in dicygotic twins with persistent congenital parvovirus B19 infection—remission following high dose intravenous immunoglobulin

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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