Skip to main content
Top
Published in: European Journal of Pediatrics 8/2014

01-08-2014 | Review

Perinatal arrhythmias

Authors: Nicole Sekarski, Erik Jan Meijboom, Stefano Di Bernardo, Tatiana Boulos Ksontini, Yvan Mivelaz

Published in: European Journal of Pediatrics | Issue 8/2014

Login to get access

Abstract

Cardiac arrhythmias are very frequent in fetuses and newborns. The prognosis depends on the nature of the arrhythmias but is most often either spontaneously benign or following short-term medication administration. A correct diagnosis is essential for both management and prognosis. It is based on echocardiography during the fetal period and mainly on history, physical exam, and electrocardiogram after birth, but other modalities are available to record transient arrhythmic events. Irregular rhythms are mostly benign and rarely require therapy. In most fetuses and infants, tachyarrhythmias resolve spontaneously or require short-term administration of antiarrhythmics. Approximately one third of these may recur later on, especially during adolescence. Persistent bradyarrhythmias might require pacemaker implantation when associated with failure to thrive or with risk of sudden death. Conclusion: Arrhythmias in fetuses and infants are very common and mostly benign. History, physical exam, and recording of the arrhythmia are essential to make a correct diagnosis and establish an appropriate management for the rare potentially harmful arrhythmias.
Literature
1.
go back to reference Andelfinger G, Fouron JC, Sonesson SE, Proulx F (2001) Reference values for time intervals between atrial and ventricular contractions of the fetal heart measured by two Doppler techniques. AJC 88:1433–1436– A8CrossRef Andelfinger G, Fouron JC, Sonesson SE, Proulx F (2001) Reference values for time intervals between atrial and ventricular contractions of the fetal heart measured by two Doppler techniques. AJC 88:1433–1436– A8CrossRef
3.
go back to reference Bauersfeld U, Pfammatter JP, Jaeggi E (2001) Treatment of supraventricular tachycardias in the new millennium—drugs or radiofrequency catheter ablation? Eur J Pediatr 160:1–9PubMedCrossRef Bauersfeld U, Pfammatter JP, Jaeggi E (2001) Treatment of supraventricular tachycardias in the new millennium—drugs or radiofrequency catheter ablation? Eur J Pediatr 160:1–9PubMedCrossRef
5.
go back to reference Brugada J, Blom N, Sarquella-Brugada G et al (2013) Pharmacological and non-pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement. Europace 15:1337–1382. doi:10.1093/europace/eut082 PubMedCrossRef Brugada J, Blom N, Sarquella-Brugada G et al (2013) Pharmacological and non-pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement. Europace 15:1337–1382. doi:10.​1093/​europace/​eut082 PubMedCrossRef
9.
go back to reference Davignon A, Rautaharju P, Boisselle E et al (1980) Normal ECG standards for infants and children. Pediatr Cardiol 1:123–152CrossRef Davignon A, Rautaharju P, Boisselle E et al (1980) Normal ECG standards for infants and children. Pediatr Cardiol 1:123–152CrossRef
10.
go back to reference Davis AM, Gow RM, McCrindle BW, Hamilton RM (1996) Clinical spectrum, therapeutic management, and follow-up of ventricular tachycardia in infants and young children. Am Heart J 131:186–191PubMedCrossRef Davis AM, Gow RM, McCrindle BW, Hamilton RM (1996) Clinical spectrum, therapeutic management, and follow-up of ventricular tachycardia in infants and young children. Am Heart J 131:186–191PubMedCrossRef
12.
go back to reference Epstein AE, DiMarco JP, Ellenbogen KA et al (2008) ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117:e350–408. doi:10.1161/CIRCUALTIONAHA.108.189742 PubMedCrossRef Epstein AE, DiMarco JP, Ellenbogen KA et al (2008) ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117:e350–408. doi:10.​1161/​CIRCUALTIONAHA.​108.​189742 PubMedCrossRef
16.
go back to reference Friedman RA, Walsh EP, Silka MJ, et al. (2002) NASPE Expert Consensus Conference: radiofrequency catheter ablation in children with and without congenital heart disease. Report of the Writing Committee. North American Society of Pacing and Electrophysiology. In: Pacing Clin Electrophysiol. pp 1000–1017 Friedman RA, Walsh EP, Silka MJ, et al. (2002) NASPE Expert Consensus Conference: radiofrequency catheter ablation in children with and without congenital heart disease. Report of the Writing Committee. North American Society of Pacing and Electrophysiology. In: Pacing Clin Electrophysiol. pp 1000–1017
17.
go back to reference Garson AJ, Gillette PC, McNamara DG (1981) Supraventricular tachycardia in children: clinical features, response to treatment, and long-term follow-up in 217 patients. J Pediatr 98:875–882PubMedCrossRef Garson AJ, Gillette PC, McNamara DG (1981) Supraventricular tachycardia in children: clinical features, response to treatment, and long-term follow-up in 217 patients. J Pediatr 98:875–882PubMedCrossRef
22.
go back to reference Jaeggi E (2009) Electrophysiology for the perinatologist. In: Yagel S, Silverman NH, Gembruch U (eds) Fetal cardiology, 2nd edn. Informa Healthcare London, New York, pp 435–447 Jaeggi E (2009) Electrophysiology for the perinatologist. In: Yagel S, Silverman NH, Gembruch U (eds) Fetal cardiology, 2nd edn. Informa Healthcare London, New York, pp 435–447
23.
24.
go back to reference Jaeggi E, Fouron JC, Drblik SP (1998) Fetal atrial flutter: diagnosis, clinical features, treatment, and outcome. J Pediatr 132:335–339PubMedCrossRef Jaeggi E, Fouron JC, Drblik SP (1998) Fetal atrial flutter: diagnosis, clinical features, treatment, and outcome. J Pediatr 132:335–339PubMedCrossRef
25.
go back to reference Jaeggi ET, Hornberger LK, Smallhorn JF, Fouron JC (2005) Prenatal diagnosis of complete atrioventricular block associated with structural heart disease: combined experience of two tertiary care centers and review of the literature. Ultrasound Obstet Gynecol 26:16–21. doi:10.1002/uog.1919 PubMedCrossRef Jaeggi ET, Hornberger LK, Smallhorn JF, Fouron JC (2005) Prenatal diagnosis of complete atrioventricular block associated with structural heart disease: combined experience of two tertiary care centers and review of the literature. Ultrasound Obstet Gynecol 26:16–21. doi:10.​1002/​uog.​1919 PubMedCrossRef
26.
go back to reference Jaeggi ET, Silverman ED, Laskin C et al (2011) Prolongation of the atrioventricular conduction in fetuses exposed to maternal anti-Ro/SSA and anti-La/SSB antibodies did not predict progressive heart block. JAC 57:1487–1492. doi:10.1016/j.jacc.2010.12.014 Jaeggi ET, Silverman ED, Laskin C et al (2011) Prolongation of the atrioventricular conduction in fetuses exposed to maternal anti-Ro/SSA and anti-La/SSB antibodies did not predict progressive heart block. JAC 57:1487–1492. doi:10.​1016/​j.​jacc.​2010.​12.​014
28.
30.
go back to reference Knick BJ, Saul PJ (2001) Immediate arrhythmia management. In: Zeigler VL, Gillette PC (eds) Practical management of pediatric cardiac arrhythmias. Futura, Armonk, NY, pp 161–230 Knick BJ, Saul PJ (2001) Immediate arrhythmia management. In: Zeigler VL, Gillette PC (eds) Practical management of pediatric cardiac arrhythmias. Futura, Armonk, NY, pp 161–230
31.
go back to reference Ko JK, Deal BJ, Strasburger JF, Benson DW (1992) Supraventricular tachycardia mechanisms and their age distribution in pediatric patients. AJC 69:1028–1032CrossRef Ko JK, Deal BJ, Strasburger JF, Benson DW (1992) Supraventricular tachycardia mechanisms and their age distribution in pediatric patients. AJC 69:1028–1032CrossRef
34.
go back to reference Lisowski LA, Verheijen PM, Benatar AA et al (2000) Atrial flutter in the perinatal age group: diagnosis, management and outcome. JAC 35:771–777 Lisowski LA, Verheijen PM, Benatar AA et al (2000) Atrial flutter in the perinatal age group: diagnosis, management and outcome. JAC 35:771–777
37.
go back to reference Mivelaz Y, Sarquella-Brugada G, Fournier A, Fouron J-C (2009) The underestimated potential of Doppler ultrasound to assess fetal arrhythmia: first report of a prenatal, transient, atypical atrioventricular block. Heart Rhythm 6:1226–1228. doi:10.1016/j.hrthm.2009.03.049 PubMedCrossRef Mivelaz Y, Sarquella-Brugada G, Fournier A, Fouron J-C (2009) The underestimated potential of Doppler ultrasound to assess fetal arrhythmia: first report of a prenatal, transient, atypical atrioventricular block. Heart Rhythm 6:1226–1228. doi:10.​1016/​j.​hrthm.​2009.​03.​049 PubMedCrossRef
38.
go back to reference Oudijk MA, Gooskens RHJM, Stoutenbeek P et al (2004) Neurological outcome of children who were treated for fetal tachycardia complicated by hydrops. Ultrasound Obstet Gynecol 24:154–158. doi:10.1002/uog.1106 PubMedCrossRef Oudijk MA, Gooskens RHJM, Stoutenbeek P et al (2004) Neurological outcome of children who were treated for fetal tachycardia complicated by hydrops. Ultrasound Obstet Gynecol 24:154–158. doi:10.​1002/​uog.​1106 PubMedCrossRef
39.
go back to reference RCPCH (2003) Medicines for children, 2nd edn. RCPCH Publications Limited, London RCPCH (2003) Medicines for children, 2nd edn. RCPCH Publications Limited, London
41.
go back to reference Riggs TW, Byrd JA, Weinhouse E (1999) Recurrence risk of supraventricular tachycardia in pediatric patients. Cardiology 91:25–30PubMedCrossRef Riggs TW, Byrd JA, Weinhouse E (1999) Recurrence risk of supraventricular tachycardia in pediatric patients. Cardiology 91:25–30PubMedCrossRef
43.
go back to reference Rosenthal E, Gordon PA, Simpson JM, Sharland GK (2005) Letter regarding article by Jaeggi et al, “Transplacental fetal treatment improves the outcome of prenatally diagnosed complete atrioventricular block without structural heart disease”. Circulation 111:e287–e288. doi:10.1161/01.CIR.0000164275.69617.B2, author reply e287–8PubMedCrossRef Rosenthal E, Gordon PA, Simpson JM, Sharland GK (2005) Letter regarding article by Jaeggi et al, “Transplacental fetal treatment improves the outcome of prenatally diagnosed complete atrioventricular block without structural heart disease”. Circulation 111:e287–e288. doi:10.​1161/​01.​CIR.​0000164275.​69617.​B2, author reply e287–8PubMedCrossRef
44.
go back to reference Sadovsky G, Nicolaides KH (1989) Reference ranges for fetal heart rate patterns in normoxaemic nonanaemic fetuses. Fetal Ther 4:61–68PubMedCrossRef Sadovsky G, Nicolaides KH (1989) Reference ranges for fetal heart rate patterns in normoxaemic nonanaemic fetuses. Fetal Ther 4:61–68PubMedCrossRef
45.
go back to reference Sanatani S, Potts JE, Reed JH et al (2012) The study of antiarrhythmic medications in infancy (SAMIS): a multicenter, randomized controlled trial comparing the efficacy and safety of digoxin versus propranolol for prophylaxis of supraventricular tachycardia in infants. Circ: Arrhythmia Electrophysiol 5:984–991. doi:10.1161/CIRCEP.112.972620 Sanatani S, Potts JE, Reed JH et al (2012) The study of antiarrhythmic medications in infancy (SAMIS): a multicenter, randomized controlled trial comparing the efficacy and safety of digoxin versus propranolol for prophylaxis of supraventricular tachycardia in infants. Circ: Arrhythmia Electrophysiol 5:984–991. doi:10.​1161/​CIRCEP.​112.​972620
46.
go back to reference Schwartz PJ, Salice P (1984) Cardiac arrhythmias in infancy: prevalence, significance and need for treatment. Eur Heart J 5 Suppl B:43–50 Schwartz PJ, Salice P (1984) Cardiac arrhythmias in infancy: prevalence, significance and need for treatment. Eur Heart J 5 Suppl B:43–50
47.
go back to reference Southall DP, Johnson AM, Shinebourne EA et al (1981) Frequency and outcome of disorders of cardiac rhythm and conduction in a population of newborn infants. PEDIATRICS 68:58–66PubMed Southall DP, Johnson AM, Shinebourne EA et al (1981) Frequency and outcome of disorders of cardiac rhythm and conduction in a population of newborn infants. PEDIATRICS 68:58–66PubMed
52.
go back to reference Walsh EP, Triedman JK, Berul CI (1992) Cardiac arrhythmias. In: Keane JF, Lock JE, Fyler DC (eds) Nadas’ pediatric cardiology, 2nd edn. Saunders Elsevier, Philadelphia, pp 377–433 Walsh EP, Triedman JK, Berul CI (1992) Cardiac arrhythmias. In: Keane JF, Lock JE, Fyler DC (eds) Nadas’ pediatric cardiology, 2nd edn. Saunders Elsevier, Philadelphia, pp 377–433
53.
go back to reference Yabek SM (1991) Ventricular arrhythmias in children with an apparently normal heart. J Pediatr 119:1–11PubMedCrossRef Yabek SM (1991) Ventricular arrhythmias in children with an apparently normal heart. J Pediatr 119:1–11PubMedCrossRef
Metadata
Title
Perinatal arrhythmias
Authors
Nicole Sekarski
Erik Jan Meijboom
Stefano Di Bernardo
Tatiana Boulos Ksontini
Yvan Mivelaz
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 8/2014
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-014-2316-4

Other articles of this Issue 8/2014

European Journal of Pediatrics 8/2014 Go to the issue