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01-03-2014 | Original Article

Body composition phenotypes and carotid intima-media thickness in 11–13-year-old children

Authors: Xavier Melo, Helena Santa-Clara, Nuno M. Pimenta, Margarida Carrolo, Sandra S. Martins, Cláudia S. Minderico, Bo Fernhall, Luís B. Sardinha

Published in: European Journal of Pediatrics | Issue 3/2014

Abstract

Early detection of impairment in vascular structure is an important clinical pursuit. However, it is unknown which measure of body composition best predicts vascular wall changes. We assess the differences in body composition among intima-media thickness (IMT) tertiles and determined which measures of body composition are associated with IMT in 385 children aged 11–13 years (196 girls). In this cross-sectional study, body mass index (BMI), waist circumference (WC), body fat mass (BFM), and trunk fat mass (TFM) from dual-energy radiographic absorptiometry and IMT through high-resolution ultrasonography were collected. Differences in body composition measures among IMT tertiles [low IMT (LIMT), ≤0.46 mm; middle IMT, 0.46–0.53 mm; higher IMT (HIMT), ≥0.53 mm] were assessed with ANOVA/ANCOVA after categorization. Regression analysis was used to assess the relationships between body composition and IMT. The groups were similar for sex, age, and maturity (p > 0.05). As compared with LIMT group, subjects with HIMT had higher mean values of BMI, BFM, TFM, and WC (p < 0.05). Significant differences were found for WC even when controlling for BMI (p < 0.05). Combining all subjects, IMT was significantly correlated to BMI, BFM, TFM, and WC (p < 0.05). In multiple regression, WC was the only predictor of IMT (β = 0.22, p < 0.001). Conclusion: Differences exist in body composition variables among IMT tertiles. In the overall model, WC was the only obesity-related predictor of increased IMT in 11–13-year-old children.

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Title: Body composition phenotypes and carotid intima-media thickness in 11–13-year-old children
Authors: Xavier Melo
Helena Santa-Clara
Nuno M. Pimenta
Margarida Carrolo
Sandra S. Martins
Cláudia S. Minderico
Bo Fernhall
Luís B. Sardinha
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 3/2014
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-013-2164-7

At a glance: The STEP trials

Springer Medicine

Body composition phenotypes and carotid intima-media thickness in 11–13-year-old children

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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