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01-02-2014 | Original Article

Pentraxin 3 as a novel early biomarker for the prediction of Henoch-Schönlein purpura nephritis in children

Authors: Wei Ge, Hai-lian Wang, Ruo-peng Sun

Published in: European Journal of Pediatrics | Issue 2/2014

Abstract

We investigated the potential role of pentraxin 3 (PTX3) in Henoch-Schönlein purpura (HSP), a common multisystemic vasculitis affecting children, as a predictor of Henoch-Schönlein purpura nephritis (HSPN). A total of 108 cases consisting of 34 children with HSP, 37 children with HSPN, and 37 healthy control children were enrolled in this prospective study from March 2010 to February 2013. Blood and urine samples were collected to measure plasma PTX3, C-reactive protein (CRP), serum creatinine, blood urea nitrogen (BUN), urine microalbumin (MALB), and β2-microglobulin (β2-MG). Median plasma PTX3 concentrations were significantly higher in children with HSPN and HSP than in control subjects before treatment (6.99, 4.18–9.78 ng/ml; 3.19, 1.13–4.27 ng/ml; 1.24, 0.87–2.08 ng/ml, respectively; all p < 0.05). Median plasma PTX3 concentrations were also significantly higher in children with HSPN than in children with HSP before treatment (6.99, 4.18–9.78 vs. 3.19, 1.13–4.27 ng/ml; p < 0.05). After treatment, median plasma PTX3 concentrations significantly decreased in children with HSP (from 3.19, 1.13–4.27 to 1.08, 0.65–2.19 ng/ml; p < 0.05) and HSPN (from 6.99, 4.18–9.78 to 1.29, 1.01–2.26 ng/ml; p < 0.05). Plasma PTX3 concentration was positively correlated with CRP (rho = 0.532, p = 0.001), MALB (rho = 0.606, p < 0.001), β2-MG (rho = 0.490, p = 0.002), and 24-h urinary protein quantity (rho = 0.650, p < 0.001) in children with HSPN. Considering vasculitis, we found that PTX3 could be used as a more efficient potential predictor of HSPN than CRP as indicated by the area under the receiver operating characteristic (ROC) curve (AUC_ROC) of PTX3 (AUC_ROC = 0.837; p < 0.001) and CRP (AUC_ROC = 0.514; p = 0.845). The threshold PTX3 concentration with optimal sensitivity and specificity was 4.30 ng/ml (sensitivity73.0 %, specificity79.6 %). Conclusion: PTX3 seems to have an important role in multisystemic vasculitis of HSP, may be involved in the development of HSPN, and used as an early biomarker to predict HSPN.

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Title: Pentraxin 3 as a novel early biomarker for the prediction of Henoch-Schönlein purpura nephritis in children
Authors: Wei Ge
Hai-lian Wang
Ruo-peng Sun
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 2/2014
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-013-2150-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Pentraxin 3 as a novel early biomarker for the prediction of Henoch-Schönlein purpura nephritis in children

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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