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European Journal of Pediatrics
Published in: European Journal of Pediatrics 8/2011

01-08-2011 | Original Paper

Application of the new pediatric criteria and Tel Hashomer criteria in heterozygous patients with clinical features of FMF

Authors: Z. Birsin Özçakar, Fatoş Yalçınkaya, Nilgün Çakar, Banu Acar, A. Evren Bilgiç, Nermin Uncu, Nazlı Kara, Mesiha Ekim, Özgür Kasapçopur

Published in: European Journal of Pediatrics | Issue 8/2011

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Abstract

Recently, a new set of criteria was established for the diagnosis of familial Mediterranean fever (FMF) in childhood. The aim of this study is to validate the new criteria set among heterozygous patients with clinical features of FMF. The study group consisted of FMF patients, who had a mutation at a single allele, who were followed in four pediatric nephrology–rheumatology centers in Turkey. Patients were evaluated by the new criteria set and also by the Tel Hashomer criteria. According to the new criteria, the diagnosis of FMF was established by the presence of two or more of five criteria (fever, abdominal pain, chest pain, arthritis, family history of FMF). The study group consisted of 110 FMF (54 male, 56 female) patients. Majority of the patients had heterozygous pM694V mutation (65%). The sensitivity of the new criteria set and that of the Tel Hashomer criteria in our study group were found to be 93% and 100%, respectively. In conclusion, this study designates that sensitivity of the new criteria set is also high in patients who had a mutation at a single allele.
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Metadata
Title
Application of the new pediatric criteria and Tel Hashomer criteria in heterozygous patients with clinical features of FMF
Authors
Z. Birsin Özçakar
Fatoş Yalçınkaya
Nilgün Çakar
Banu Acar
A. Evren Bilgiç
Nermin Uncu
Nazlı Kara
Mesiha Ekim
Özgür Kasapçopur
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 8/2011
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-011-1404-y

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