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01-07-2011 | Original Paper

The impact of prophylaxis on paediatric intensive care unit admissions for RSV infection: a retrospective, single-centre study

Authors: Michelle L. Butt, Amanda Symington, Marianne Janes, LouAnn Elliott, Susan Steele, Bosco A. Paes

Published in: European Journal of Pediatrics | Issue 7/2011

Abstract

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections and hospitalizations in children aged <2 years. The aim of this retrospective, single-centre study was to examine the characteristics of patients admitted to a paediatric intensive care unit (PICU) with RSV infection following the implementation of a RSV prophylaxis programme. Electronic hospital medical records of all PICU admissions for RSV infection were searched from 2003 to 2009. Data on baseline demographics, underlying disease, criteria for hospitalization, respiratory diagnosis and management, complications and palivizumab prophylaxis were collected. A total of 181 patients were admitted with RSV infection, accounting for 5.7% of all admissions. Eighty-four percent were ≤2 years of age. Majority (70.2%) had no underlying medical illness, and 79.6% received antibiotics as part of their medical treatment. Comparison of children aged ≤2 years and those >2 years revealed that fewer of the younger cohort (20.4% versus 79.3%; p < 0.001) had an underlying medical condition. RSV infection occurred in 3.3% (n = 6) children who had received palivizumab prophylaxis, and there were two deaths. The results indicate that >88% of all PICU admissions would not qualify for RSV prophylaxis under our established guidelines and 66% of the children aged ≤2 years were >36 weeks gestation and are not currently targeted for prophylaxis. The number of high-risk infants admitted to PICU with RSV infection has likely plateaued, and further reductions in admission rates may only be realised with the use of universal, vaccine immunization programmes.

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Title: The impact of prophylaxis on paediatric intensive care unit admissions for RSV infection: a retrospective, single-centre study
Authors: Michelle L. Butt
Amanda Symington
Marianne Janes
LouAnn Elliott
Susan Steele
Bosco A. Paes
Publication date: 01-07-2011
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 7/2011
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-010-1376-3

At a glance: The STEP trials

Springer Medicine

The impact of prophylaxis on paediatric intensive care unit admissions for RSV infection: a retrospective, single-centre study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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