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European Journal of Pediatrics
Published in: European Journal of Pediatrics 4/2010

01-04-2010 | Review

Clinical practice

Heart failure in children. Part II: current maintenance therapy and new therapeutic approaches

Authors: Paul F. Kantor, Luc L. Mertens

Published in: European Journal of Pediatrics | Issue 4/2010

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Abstract

The current maintenance treatment for children with heart failure remains controversial: To a large extent, it is based on extrapolation of data derived from trials in adult populations. There are only a few randomized trials focused on the treatment of children with cardiac disease, especially in the subgroup with cardiomyopathy and heart failure. The goals of therapy are to maintain circulatory and end-organ function and to allow for recovery and reverse remodeling to occur. When maintenance therapy fails and medical treatment does not result in clinical improvement, the alternative of device therapy must be considered: In that case, the usual aim is to stabilize circulatory status, as a bridge to either recovery or to cardiac transplantation. Recently, carefully selected patients with electromechanical dyssynchrony of ventricular systolic function have demonstrated a benefit from biventricular pacing devices (cardiac resynchronization therapy), with improved functional capacity and quality of life and, in some patients, avoidance of the need for transplantation.
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Metadata
Title
Clinical practice
Heart failure in children. Part II: current maintenance therapy and new therapeutic approaches
Authors
Paul F. Kantor
Luc L. Mertens
Publication date
01-04-2010
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 4/2010
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-009-1133-7

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